{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:36:22Z","timestamp":1791203782873,"version":"4.2.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T00:00:00Z","timestamp":1181001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Institute for Animal Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Follicular dendritic cells (FDC) in the germinal centers (GC) of secondary lymphoid organs increase the survival and proliferation of antigen-stimulated B cells and are pivotal for the affinity maturation of an antibody response and for maintenance of B cell immunological memory. The dark zone (DZ) and the light zone (LZ) constitute distinct areas of the GC containing different subtypes of FDC as identified by their morphology and phenotype. Until now, most available FDC-specific reagents identify LZ FDC, and there are no reagents recognizing DZ FDC specifically. Here, we report a new mAb, D46, which stains FDC specifically in the DZ of bovine and ovine GC within the secondary follicles. We identify its ligand as bovine fibrinogen, and using commercially available anti-human fibrinogen antibodies, show that this inflammatory protein is also present on DZ FDC of human GC within palatine tonsils. In vitro, the addition of exogenous fibrinogen stimulates the proliferation and survival of BCR-stimulated L3055 cells, which constitute a clonal population of centroblastic cells and retain important features of normal GC B cells. Together, our results suggest that fibrinogen localized on DZ FDC could support the extensive proliferation and survival of GC B cells within the DZ in vivo.<\/jats:p>","DOI":"10.1189\/jlb.0107050","type":"journal-article","created":{"date-parts":[[2007,6,6]],"date-time":"2007-06-06T02:09:22Z","timestamp":1181095762000},"page":"666-677","source":"Crossref","is-referenced-by-count":15,"title":["Fibrinogen is localized on dark zone follicular dendritic cells in vivo and enhances the proliferation and survival of a centroblastic cell line in vitro"],"prefix":"10.1093","volume":"82","author":[{"given":"Eric A","family":"Lefevre","sequence":"first","affiliation":[{"name":"Compton Laboratory, Institute for Animal Health , Compton , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne R","family":"Hein","sequence":"additional","affiliation":[{"name":"AgResearch Ltd., Wallaceville Animal Research Centre , Upper Hutt , New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zania","family":"Stamataki","sequence":"additional","affiliation":[{"name":"Compton Laboratory, Institute for Animal Health , Compton , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise S","family":"Brackenbury","sequence":"additional","affiliation":[{"name":"Compton Laboratory, Institute for Animal Health , Compton , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma A","family":"Supple","sequence":"additional","affiliation":[{"name":"Compton Laboratory, Institute for Animal Health , Compton , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence G","family":"Hunt","sequence":"additional","affiliation":[{"name":"Compton Laboratory, Institute for Animal Health , Compton , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Monaghan","sequence":"additional","affiliation":[{"name":"Pirbright Laboratory, Institute for Animal Health , Pirbright , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenoline","family":"Borhis","sequence":"additional","affiliation":[{"name":"Service d\u2019Immuno-Virologie, Commissariat \u00e0 l\u2019Energie Atomique, DSV\/iMETI , Fontenay aux Roses , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolande","family":"Richard","sequence":"additional","affiliation":[{"name":"Service d\u2019Immuno-Virologie, Commissariat \u00e0 l\u2019Energie Atomique, DSV\/iMETI , Fontenay aux Roses , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Charleston","sequence":"additional","affiliation":[{"name":"Compton Laboratory, Institute for Animal Health , Compton , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,6,5]]},"reference":[{"key":"2023033006503238900_","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1096\/fasebj.8.11.8070632","article-title":"Biology of germinal centers in lymphoid tissue","volume":"8","author":"Thorbecke","year":"1994","journal-title":"FASEB J."},{"key":"2023033006503238900_","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1002\/eji.1830211209","article-title":"Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens","volume":"21","author":"Liu","year":"1991","journal-title":"Eur. 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