{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T03:57:58Z","timestamp":1778990278452,"version":"3.51.4"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft DFG","award":["Gu454\/5-2"],"award-info":[{"award-number":["Gu454\/5-2"]}]},{"name":"Deutsche Forschungsgemeinschaft DFG","award":["BA 2071\/2-2"],"award-info":[{"award-number":["BA 2071\/2-2"]}]},{"name":"Austrian Science Fund","award":["T545-B19"],"award-info":[{"award-number":["T545-B19"]}]},{"name":"European Community","award":["BM0806"],"award-info":[{"award-number":["BM0806"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Histamine down-regulates IL-27 production in monocytes, and stimulation of keratinocytes with supernatants from histamine-treated monocytes down-regulates CXCL10 secretion.<\/jats:p><jats:p>Histamine is a potent mediator in allergic inflammation with immunomodulatory properties. Since histamine was described to inhibit IL-12 production in human APCs, we hypothesized that also the expression of IL-27, a newly described member of the IL-12 family, which is present in inflammatory skin lesions, is modulated by histamine. Stimulation of human monocytes with histamine resulted in significant reduction of TLR ligand-induced IL-27 production in human monocytes. IL-27 subunits, p28 and EBI3, were down-regulated at the mRNA and protein level, whereas other cytokines, such as IL-6, IL-10, and TNF-\u03b1, were not influenced. Studies with histamine receptor-specific agonists and antagonists showed that the down-regulation of IL-27 was mediated via H2R and H4R but not H1R and H3R. Human KCs treated with supernatants of histamine-prestimulated monocytes induced significantly less CXCL10 than supernatants containing high levels of IL-27. DCs from H4R\u2212\/\u2212 mice responded to TLR simulation with higher IL-27 production as compared with WT mice. The down-regulation of IL-27 by histamine might be a new mechanism in the pathogenesis of inflammatory skin diseases, in particular, if increased concentrations of histamine are present at sites of inflammation, such as in chronic eczema and psoriasis.<\/jats:p>","DOI":"10.1189\/jlb.0111017","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T17:07:07Z","timestamp":1330967227000},"page":"21-29","source":"Crossref","is-referenced-by-count":28,"title":["Histamine down-regulates IL-27 production in antigen-presenting cells"],"prefix":"10.1093","volume":"92","author":[{"given":"Maria","family":"Gschwandtner","sequence":"first","affiliation":[{"name":"Hannover Medical School, Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research , Hannover, Germany"},{"name":"Medical University of Vienna, Department of Dermatology , Vienna, Austria"},{"name":"Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover Foundation , Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Bunk","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover Foundation , Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitta","family":"K\u00f6ther","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research , Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin L","family":"Thurmond","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover Foundation , Hannover, Germany"},{"name":"Johnson & Johnson Pharmaceutical Research & Development , San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Kietzmann","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover Foundation , Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Werfel","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research , Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"B\u00e4umer","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover Foundation , Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Gutzmer","sequence":"additional","affiliation":[{"name":"Hannover Medical School, Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research , Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2012,7,1]]},"reference":[{"key":"2023012312541756900_B1","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.jaci.2011.06.051","article-title":"Regulation of the immune response and inflammation by histamine and histaminereceptors","volume":"128","author":"O'Mahony","year":"2011","journal-title":"J. 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