{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:28:48Z","timestamp":1791264528780,"version":"4.1.0"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Progetti Strategici Oncologici"},{"name":"Ministero della Salute 2006","award":["#5747"],"award-info":[{"award-number":["#5747"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Review of the role of the CX3CL1\/CX3CR1 axis in the regulation of normal B cells and malignant B cell microenvironment.<\/jats:p>\n               <jats:p>CX3CL1, or fractalkine, the unique member of the CX3C chemokine family, exists as a transmembrane glycoprotein, as well as in soluble form, each mediating different biological activities, and is constitutively expressed in many hematopoietic and nonhematopoietic tissues. CX3CR1, the CX3CL1 exclusive receptor, is a classical GPCR, expressed on NK cells, CD14+ monocytes, and some subpopulation of T cells, B cells, and mast cells. A recent paper by our group has demonstrated for the first time that highly purified human B cells from tonsil and peripheral blood expressed CX3CR1 at mRNA and protein levels. In particular, tonsil na\u00efve, GC, and memory B cells expressed CX3CR1, but only GC centrocytes were attracted by soluble CX3CL1, which with its receptor, are also involved in the pathogenesis of several inflammatory disorders, as well as of cancer. Previous studies have shown that CX3CR1 is up-regulated in different types of B cell lymphoma, as well as in B-CLL. Recently, we have demonstrated that the CX3CL1\/CX3CR1 axis is involved in the interaction of B-CLL cells with their microenvironment. Taken together, our data delineate a novel role for the CX3CL1\/CX3CR1 complex in the biology of normal B cells and B-CLL cells. These topics are the subject of this review article.<\/jats:p>","DOI":"10.1189\/jlb.0112035","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T00:35:02Z","timestamp":1332981302000},"page":"51-58","source":"Crossref","is-referenced-by-count":22,"title":["CX3CL1\/fractalkine is a novel regulator of normal and malignant human B cell function"],"prefix":"10.1093","volume":"92","author":[{"given":"Anna","family":"Corcione","sequence":"first","affiliation":[{"name":"Laboratory of Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico G. Gaslini , Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Laboratory of Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico G. Gaslini , Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Pistoia","sequence":"additional","affiliation":[{"name":"Laboratory of Oncology, Istituto Di Ricovero e Cura a Carattere Scientifico G. Gaslini , Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,7,1]]},"reference":[{"key":"2023012312542593800_B1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/33340","article-title":"Chemokines and leukocyte traffic","volume":"392","author":"Baggiolini","year":"1998","journal-title":"Nature"},{"key":"2023012312542593800_B2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1074-7613(00)80165-X","article-title":"Chemokines: a new classification system and their role in immunity","volume":"12","author":"Zlotnik","year":"2000","journal-title":"Immunity"},{"key":"2023012312542593800_B3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/path.3029","article-title":"The chemokine system and cancer","volume":"226","author":"Balkwill","year":"2012","journal-title":"J. Pathol."},{"key":"2023012312542593800_B4","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S1471-4906(01)01941-X","article-title":"Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines","volume":"22","author":"Mantovani","year":"2001","journal-title":"Trends Immunol."},{"key":"2023012312542593800_B5","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nri1964","article-title":"Tuning inflammation and immunity by chemokine sequestration: decoys and more","volume":"6","author":"Mantovani","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2023012312542593800_B6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0167-5699(99)01469-3","article-title":"The chemokine system: redundancy for robust outputs","volume":"20","author":"Mantovani","year":"1999","journal-title":"Immunol. Today"},{"key":"2023012312542593800_B7","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S1471-4906(01)02051-8","article-title":"Fractalkine and vascular injury","volume":"22","author":"Umehara","year":"2001","journal-title":"Trends Immunol."},{"key":"2023012312542593800_B8","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/385640a0","article-title":"A new class of membrane-bound chemokine with a CX3C motif","volume":"385","author":"Bazan","year":"1997","journal-title":"Nature"},{"key":"2023012312542593800_B9","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0092-8674(00)80438-9","article-title":"Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion","volume":"91","author":"Imai","year":"1997","journal-title":"Cell"},{"key":"2023012312542593800_B10","doi-asserted-by":"crossref","first-page":"e8485","DOI":"10.1371\/journal.pone.0008485","article-title":"CX3CR1 is expressed by human B lymphocytes and meditates CX3CL1 driven chemotaxis of tonsil centrocytes","volume":"4","author":"Corcione","year":"2009","journal-title":"PLoS ONE"},{"key":"2023012312542593800_B11","doi-asserted-by":"crossref","first-page":"44622","DOI":"10.1074\/jbc.M107327200","article-title":"Tumor necrosis factor-\u03b1-converting enzyme mediates the inducible cleavage of fractalkine","volume":"276","author":"Tsou","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2023012312542593800_B12","doi-asserted-by":"crossref","first-page":"37993","DOI":"10.1074\/jbc.M106434200","article-title":"Tumor necrosis factor-\u03b1-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)","volume":"276","author":"Garton","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2023012312542593800_B13","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1084\/jem.188.8.1413","article-title":"Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow","volume":"188","author":"Fong","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023012312542593800_B14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.5551\/jat.11.15","article-title":"Regulation of CX3CL1\/ fractalkine expression in endothelial cells","volume":"11","author":"Imaizumi","year":"2004","journal-title":"J. Atheroscler. Thromb."},{"key":"2023012312542593800_B15","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.4049\/jimmunol.164.6.3368","article-title":"Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa","volume":"164","author":"Muehlhoefer","year":"2000","journal-title":"J. Immunol."},{"key":"2023012312542593800_B16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/1521-4141(200001)30:1<87::AID-IMMU87>3.0.CO;2-7","article-title":"Fractalkine receptor expression by T lymphocyte subpopulations and in vivo production of fractalkine in human","volume":"30","author":"Foussat","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"2023012312542593800_B17","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1002\/(SICI)1521-4141(199908)29:08<2551::AID-IMMU2551>3.0.CO;2-T","article-title":"Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation","volume":"29","author":"Papadopoulos","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"2023012312542593800_B18","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jpain.2005.02.001","article-title":"Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain","volume":"6","author":"Lindia","year":"2005","journal-title":"J. Pain"},{"key":"2023012312542593800_B19","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1460-9568.2004.03593.x","article-title":"Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions","volume":"20","author":"Verge","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"2023012312542593800_B20","doi-asserted-by":"crossref","first-page":"7825","DOI":"10.4049\/jimmunol.0803627","article-title":"Role of CX3CL1\/fractalkine in osteoclast differentiation and bone resorption","volume":"183","author":"Koizumi","year":"2009","journal-title":"J. Immunol."},{"key":"2023012312542593800_B21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1572-0241.2005.00361.x","article-title":"Increased expression of the chemokine fractalkine in Crohn's disease and association of the fractalkine receptor T280M polymorphism with a fibrostenosing disease phenotype","volume":"101","author":"Brand","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"2023012312542593800_B22","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.jaci.2003.09.041","article-title":"The CX3C chemokine fractalkine in allergic asthma and rhinitis","volume":"112","author":"Rimaniol","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"2023012312542593800_B23","first-page":"1918","article-title":"Proinflammatory role of fractalkine (CX3CL1) in rheumatoid arthritis","volume":"30","author":"Blaschke","year":"2003","journal-title":"J. Rheumatol."},{"key":"2023012312542593800_B24","first-page":"424","article-title":"Fractalkine\u2014a proinflammatory chemokine in rheumatoid arthritis","volume":"67","author":"Blaschke","year":"2008","journal-title":"Z. Rheumatol."},{"key":"2023012312542593800_B25","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1161\/01.CIR.0000097119.57756.EF","article-title":"Smooth muscle cells in human atherosclerotic plaques express the fractalkine receptor CX3CR1 and undergo chemotaxis to the CX3C chemokine fractalkine (CX3CL1)","volume":"108","author":"Lucas","year":"2003","journal-title":"Circulation"},{"key":"2023012312542593800_B26","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1161\/CIRCULATIONAHA.107.743872","article-title":"Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-\/- mice: evidence for independent chemokine functions in atherogenesis","volume":"117","author":"Saederup","year":"2008","journal-title":"Circulation"},{"key":"2023012312542593800_B27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0014-5793(98)00583-3","article-title":"Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?","volume":"429","author":"Nishiyori","year":"1998","journal-title":"FEBS Lett."},{"key":"2023012312542593800_B28","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nn1715","article-title":"Control of microglial neurotoxicity by the fractalkine receptor","volume":"9","author":"Cardona","year":"2006","journal-title":"Nat. Neurosci."},{"key":"2023012312542593800_B29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.canlet.2008.07.029","article-title":"The involvement of the fractalkine receptor in the transmigration of neuroblastoma cells through bone-marrow endothelial cells","volume":"273","author":"Nevo","year":"2009","journal-title":"Cancer Lett."},{"key":"2023012312542593800_B30","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1158\/0008-5472.CAN-06-3041","article-title":"Fractalkine (CX3CL1)- and interleukin-2-enriched neuroblastoma microenvironment induces eradication of metastases mediated by T cells and natural killer cells","volume":"67","author":"Zeng","year":"2007","journal-title":"Cancer Res."},{"key":"2023012312542593800_B31","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1046\/j.1523-1755.2002.00480.x","article-title":"Expression of the fractalkine receptor (CX3CR1) in human kidney diseases","volume":"62","author":"Segerer","year":"2002","journal-title":"Kidney Int."},{"key":"2023012312542593800_B32","first-page":"41","article-title":"The high expression of fractalkine results in a better prognosis for colorectal cancer patients","volume":"26","author":"Ohta","year":"2005","journal-title":"Int. J. Oncol."},{"key":"2023012312542593800_B33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/jso.20642","article-title":"Fractalkine-CX3CR1 axis regulates tumor cell cycle and deteriorates prognosis after radical resection for hepatocellular carcinoma","volume":"95","author":"Matsubara","year":"2007","journal-title":"J. Surg. Oncol."},{"key":"2023012312542593800_B34","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1158\/0008-5472.CAN-03-3437","article-title":"CX3CR1-fractalkine expression regulates cellular mechanisms involved in adhesion, migration, and survival of human prostate cancer cells","volume":"64","author":"Shulby","year":"2004","journal-title":"Cancer Res."},{"key":"2023012312542593800_B35","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1158\/0008-5472.CAN-07-1315","article-title":"CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1\/fractalkine in the bone marrow: potential role in prostate cancer bone tropism","volume":"68","author":"Jamieson","year":"2008","journal-title":"Cancer Res."},{"key":"2023012312542593800_B36","doi-asserted-by":"crossref","first-page":"9060","DOI":"10.1158\/0008-5472.CAN-08-1810","article-title":"The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma","volume":"68","author":"Marchesi","year":"2008","journal-title":"Cancer Res."},{"key":"2023012312542593800_B37","doi-asserted-by":"crossref","first-page":"e21546","DOI":"10.1371\/journal.pone.0021546","article-title":"Identification of the chemokine CX3CL1 as a new regulator of malignant cell proliferation in epithelial ovarian cancer","volume":"6","author":"Gaudin","year":"2011","journal-title":"PLoS ONE"},{"key":"2023012312542593800_B38","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1016\/j.ejca.2010.07.022","article-title":"Human glioblastoma tumours and neural cancer stem cells express the chemokine CX3CL1 and its receptor CX3CR1","volume":"46","author":"Erreni","year":"2010","journal-title":"Eur. J. Cancer"},{"key":"2023012312542593800_B39","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.yexcr.2010.02.018","article-title":"CX3CR1 promotes recruitment of human glioma-infiltrating microglia\/macrophages (GIMs)","volume":"316","author":"Held-Feindt","year":"2010","journal-title":"Exp. Cell. Res."},{"key":"2023012312542593800_B40","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/neuonc\/nop076","article-title":"CX3CR1\/CX3CL1 axis negatively controls glioma cell invasion and is modulated by transforming growth factor-\u03b21","volume":"12","author":"Sciume","year":"2010","journal-title":"Neuro. Oncol."},{"key":"2023012312542593800_B41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1146\/annurev.iy.12.040194.001001","article-title":"Germinal centers","volume":"12","author":"MacLennan","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"2023012312542593800_B42","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.immuni.2007.07.009","article-title":"Germinal-center organization and cellular dynamics","volume":"27","author":"Allen","year":"2007","journal-title":"Immunity"},{"key":"2023012312542593800_B43","doi-asserted-by":"crossref","first-page":"8755","DOI":"10.1073\/pnas.1101554108","article-title":"B cells within germinal centers migrate preferentially from dark to light zone","volume":"108","author":"Beltman","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023012312542593800_B44","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ni1100","article-title":"Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5","volume":"5","author":"Allen","year":"2004","journal-title":"Nat. Immunol."},{"key":"2023012312542593800_B45","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/jnci\/92.8.628","article-title":"Stromal cell-derived factor-1 as a chemoattractant for follicular center lymphoma B cells","volume":"92","author":"Corcione","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"2023012312542593800_B46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1365-2567.1997.d01-2131.x","article-title":"Locomotor properties of human germinal centre B cells: activation by anti-CD40 and IL-4 allows chemoattraction by anti-immunoglobulin","volume":"90","author":"Komai-Koma","year":"1997","journal-title":"Immunology"},{"key":"2023012312542593800_B47","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1182\/blood.V97.7.2031","article-title":"Signal transduction pathways involved in soluble fractalkine-induced monocytic cell adhesion","volume":"97","author":"Cambien","year":"2001","journal-title":"Blood"},{"key":"2023012312542593800_B48","doi-asserted-by":"crossref","first-page":"31831","DOI":"10.1074\/jbc.M009374200","article-title":"Phosphatidylinositol 3-kinase-dependent extracellular calcium influx is essential for CX(3)CR1-mediated activation of the mitogen-activated protein kinase cascade","volume":"276","author":"Kansra","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2023012312542593800_B49","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1084\/jem.185.3.563","article-title":"Germinal center founder cells display propensity for apoptosis before onset of somatic mutation","volume":"185","author":"Lebecque","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023012312542593800_B50","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1084\/jem.188.9.1679","article-title":"Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells","volume":"188","author":"Klein","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023012312542593800_B51","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.it.2006.03.005","article-title":"Apoptotic cell removal in development and tissue homeostasis","volume":"27","author":"Henson","year":"2006","journal-title":"Trends Immunol."},{"key":"2023012312542593800_B52","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1182\/blood-2008-06-162404","article-title":"CX3CL1\/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis","volume":"112","author":"Truman","year":"2008","journal-title":"Blood"},{"key":"2023012312542593800_B53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF02786360","article-title":"Differentiation and apoptosis of human germinal center B-lymphocytes","volume":"16","author":"Choi","year":"1997","journal-title":"Immunol. Res."},{"key":"2023012312542593800_B54","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1046\/j.1365-2141.2003.04679.x","article-title":"Role of the microenvironment in chronic lymphocytic leukaemia","volume":"123","author":"Caligaris-Cappio","year":"2003","journal-title":"Br. J. Haematol."},{"key":"2023012312542593800_B55","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10456-009-9135-7","article-title":"Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature","volume":"12","author":"Ahn","year":"2009","journal-title":"Angiogenesis"},{"key":"2023012312542593800_B56","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1182\/blood.V96.8.2655","article-title":"Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1","volume":"96","author":"Burger","year":"2000","journal-title":"Blood"},{"key":"2023012312542593800_B57","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1182\/blood.V91.7.2387","article-title":"Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells","volume":"91","author":"Lagneaux","year":"1998","journal-title":"Blood"},{"key":"2023012312542593800_B58","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1182\/blood.V100.5.1795.h81702001795_1795_1801","article-title":"Protection of CLL B cells by a follicular dendritic cell line is dependent on induction of Mcl-1","volume":"100","author":"Pedersen","year":"2002","journal-title":"Blood"},{"key":"2023012312542593800_B59","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1182\/blood-2003-09-3103","article-title":"Homeostatic chemokines drive migration of malignant B cells in patients with non-Hodgkin lymphomas","volume":"104","author":"Trentin","year":"2004","journal-title":"Blood"},{"key":"2023012312542593800_B60","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1158\/1078-0432.CCR-1182-3","article-title":"CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells","volume":"10","author":"Corcione","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"2023012312542593800_B61","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/sj.leu.2402107","article-title":"Differential expression of chemokine receptors in B cell malignancies","volume":"15","author":"Durig","year":"2001","journal-title":"Leukemia"},{"key":"2023012312542593800_B62","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1182\/blood-2008-10-185827","article-title":"Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting","volume":"113","author":"Kurtova","year":"2009","journal-title":"Blood"},{"key":"2023012312542593800_B63","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1084\/jem.194.1.45","article-title":"A coordinated change in chemokine responsiveness guides plasma cell movements","volume":"194","author":"Hargreaves","year":"2001","journal-title":"J. Exp. Med."},{"key":"2023012312542593800_B64","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1182\/blood.V94.11.3658","article-title":"Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells","volume":"94","author":"Burger","year":"1999","journal-title":"Blood"},{"key":"2023012312542593800_B65","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1182\/blood-2005-08-3182","article-title":"CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment","volume":"107","author":"Burger","year":"2006","journal-title":"Blood"},{"key":"2023012312542593800_B66","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.canlet.2007.10.031","article-title":"B cell lymphomas express CX3CR1 a non-B cell lineage adhesion molecule","volume":"259","author":"Andreasson","year":"2008","journal-title":"Cancer Lett."},{"key":"2023012312542593800_B67","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cancergencyto.2003.12.016","article-title":"Different gene expression in immunoglobulin-mutated and immunoglobulin-unmutated forms of chronic lymphocytic leukemia","volume":"153","author":"Ferrer","year":"2004","journal-title":"Cancer Genet. Cytogenet."},{"key":"2023012312542593800_B68","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/leu.2011.88","article-title":"A novel role of the CX3CR1\/CX3CL1 system in the cross-talk between chronic lymphocytic leukemia cells and tumor microenvironment","volume":"25","author":"Ferretti","year":"2011","journal-title":"Leukemia"},{"key":"2023012312542593800_B69","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1365-2559.1994.tb00553.x","article-title":"Proliferation centres in B-cell malignant lymphoma, lymphocytic (B-CLL): an immunophenotypic study","volume":"24","author":"Schmid","year":"1994","journal-title":"Histopathology"},{"key":"2023012312542593800_B70","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1182\/blood-2009-06-225326","article-title":"The microenvironment in mature B-cell malignancies: a target for new treatment strategies","volume":"114","author":"Burger","year":"2009","journal-title":"Blood"},{"key":"2023012312542593800_B71","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1182\/blood-2007-05-089409","article-title":"Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia","volume":"110","author":"Burkle","year":"2007","journal-title":"Blood"},{"key":"2023012312542593800_B72","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1182\/blood-2004-03-0889","article-title":"Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1\u03b1","volume":"106","author":"Nishio","year":"2005","journal-title":"Blood"},{"key":"2023012312542593800_B73","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1182\/blood-2004-10-3873","article-title":"CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival","volume":"105","author":"Deaglio","year":"2005","journal-title":"Blood"},{"key":"2023012312542593800_B74","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1182\/blood-2004-09-3507","article-title":"Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets","volume":"106","author":"Sordi","year":"2005","journal-title":"Blood"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1189%2Fjlb.0112035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/92\/1\/51\/48765087\/jlb0051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/92\/1\/51\/48765087\/jlb0051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T13:11:59Z","timestamp":1677503519000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/92\/1\/51\/6936213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,1]]},"references-count":74,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,7,1]]},"published-print":{"date-parts":[[2012,7,1]]}},"URL":"https:\/\/doi.org\/10.1189\/jlb.0112035","relation":{},"ISSN":["1938-3673","0741-5400"],"issn-type":[{"value":"1938-3673","type":"electronic"},{"value":"0741-5400","type":"print"}],"subject":[],"published-other":{"date-parts":[[2012,7]]},"published":{"date-parts":[[2012,7,1]]}}}