{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:13:18Z","timestamp":1791688398114,"version":"4.3.4"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Fundaci\u00f3n Marqu\u00e9s de Valdecilla, Fondo de Investigaci\u00f3n Sanitaria","award":["PI050475"],"award-info":[{"award-number":["PI050475"]}]},{"name":"Fundaci\u00f3n Marqu\u00e9s de Valdecilla, Fondo de Investigaci\u00f3n Sanitaria","award":["PI080098"],"award-info":[{"award-number":["PI080098"]}]},{"name":"Fundaci\u00f3n Marqu\u00e9s de Valdecilla-IFIMAV"},{"name":"Fundaci\u00f3n Marqu\u00e9s de Valdecilla-IFIMAV"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study was conducted to evaluate phagocyte function in patients with age-related chronic inflammatory conditions. It included 95 patients with PMR, 17 with GCA, 40 with EORA, and 25 age-matched HCs. Serum IL-8 was determined with a bead array. The chemotactic capacity, phagocytic ability, and oxidative burst activity of circulating leukocytes were determined with flow cytometry kits. Patients with active chronic inflammatory diseases showed a significant increase in circulating levels of IL-8 that remained elevated in patients with PMR or EORA, despite treatment. No correlation was found between circulating IL-8 and the migratoty capacity of neutrophils. Neutrophils from patients with active EORA without stimulus and after fMLP stimuli showed a higher capacity to migrate than those of the HCs (P=0.033). The phagocytic activity of granulocytes in the patients with GCA was significantly higher than in the HCs and the patients with PMR or EORA (P&amp;lt;0.05). The percentage and MFI of phagocytes that produce ROIs when stimulated with Escherichia coli was significantly reduced in neutrophils and monocytes from the patients with age-restricted inflammatory conditions. We concluded that the effector functions of phagocytes, determined to be chemotaxis, phagocytosis, and oxidative burst, are deregulated in age-restricted inflammatory disorders and may have a pathogenic role.<\/jats:p>","DOI":"10.1189\/jlb.0113034","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T04:39:52Z","timestamp":1375331992000},"page":"1071-1078","source":"Crossref","is-referenced-by-count":13,"title":["Phagocyte dysfunction in polymyalgia rheumatica and other age-related, chronic, inflammatory conditions"],"prefix":"10.1093","volume":"94","author":[{"given":"Lorena","family":"\u00c1lvarez-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Divisions of Rheumatology, Universidad de Cantabria , Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"L\u00f3pez-Hoyos","sequence":"additional","affiliation":[{"name":"Immunology, Hospital Universitario Marqu\u00e9s de Valdecilla, Instituto de Formaci\u00f3n e Investigaci\u00f3n Marqu\u00e9s de Valdecilla (IFIMAV), Facultad de Medicina, Universidad de Cantabria , Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Calvo-Al\u00e9n","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Reumatolog\u00eda, Hospital de Sierrallana , Torrelavega, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Aurrecoechea","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Reumatolog\u00eda, Hospital de Sierrallana , Torrelavega, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Villa","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Reumatolog\u00eda, Hospital de Sierrallana , Torrelavega, Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor Manuel","family":"Mart\u00ednez-Taboada","sequence":"additional","affiliation":[{"name":"Divisions of Rheumatology, Universidad de Cantabria , Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"2023032711571246600_","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2431-11-29","article-title":"Phagocytic ability of neutrophils and monocytes in neonates","volume":"11","author":"Filias","year":"2011","journal-title":"BMC Pediatr."},{"key":"2023032711571246600_","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0531-5565(98)00012-6","article-title":"Age-associated differences in neutrophil oxidative burst (chemiluminescence)","volume":"33","author":"Braga","year":"1998","journal-title":"Exp. 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