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IL-1R2 acts as a decoy receptor and has been shown to regulate the biological effects of IL-1 in vitro and in vivo. However, little is known about its natural expression in the mouse in physiologic and pathologic conditions. In this study, we examined IL-1R2 mRNA and protein expression in isolated cells and tissues in response to different stimulatory conditions. Data obtained using ex vivo CD11b+Ly6G+ peripheral blood cells and in vitro-differentiated CD11b+Ly6G+ BMG indicated that neutrophils are the major source of constitutively expressed IL-1R2 in the mouse. The expression of IL-1R2 on BMG and ex vivo Ly6G+ peripheral blood cells was highly up-regulated by HC. IL-1R2 pull-down experiments showed that mouse rIL-1\u03b2 binds to BMG IL-1R2, whereas binding of IL-1Ra could not be detected. Furthermore, LPS treatment induced shedding of IL-1R2 from the neutrophil membrane in vitro and in vivo, executed mainly by ADAM17. Finally, in in vivo models of inflammation, including thioglycolate-induced acute peritonitis and acute lung injury, infiltrating Ly6G+ neutrophils, expressed IL-1R2. Our data show that in the mouse, neutrophils mainly express the decoy receptor IL-1R2 under na\u00efve and inflammatory conditions. These data suggest that neutrophils may contribute to the resolution of acute inflammation.<\/jats:p>","DOI":"10.1189\/jlb.0113035","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T01:13:17Z","timestamp":1372727597000},"page":"791-802","source":"Crossref","is-referenced-by-count":63,"title":["Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions"],"prefix":"10.1093","volume":"94","author":[{"given":"Praxedis","family":"Martin","sequence":"first","affiliation":[{"name":"Division of Rheumatology and Department of Pathology-Immunology, University of Geneva, School of Medicine , Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaby","family":"Palmer","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Department of Pathology-Immunology, University of Geneva, School of Medicine , Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solenne","family":"Vigne","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Department of Pathology-Immunology, University of Geneva, School of Medicine , Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Lamacchia","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Department of Pathology-Immunology, University of Geneva, School of Medicine , Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliana","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Department of Pathology-Immunology, University of Geneva, School of Medicine , Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Talabot-Ayer","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Department of Pathology-Immunology, University of Geneva, School of Medicine , Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Rose-John","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Christian-Albrechts-University Kiel , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athena","family":"Chalaris","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Christian-Albrechts-University Kiel , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Gabay","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Department of Pathology-Immunology, University of Geneva, School of Medicine , Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"2023032711573591300_","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-065X.2008.00624.x","article-title":"IL-1, IL-18, and IL-33 families of cytokines","volume":"223","author":"Arend","year":"2008","journal-title":"Immunol. 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