{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:04:19Z","timestamp":1791180259342,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Mentored Clinical Scientist Research Career Development Award","award":["K08 DE020882"],"award-info":[{"award-number":["K08 DE020882"]}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01AI29690"],"award-info":[{"award-number":["R01AI29690"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000093","name":"U.S. National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003982","name":"National institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003982","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Feinstein Institute for Medical Research"},{"name":"North Shore-LIJ Health System General Clinical Research Center","award":["M01 RR018535"],"award-info":[{"award-number":["M01 RR018535"]}]},{"DOI":"10.13039\/501100012264","name":"U.S. NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"NCRR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>SS is an autoimmune disease. pSS affects exocrine glands predominantly, whereas sSS occurs with other autoimmune connective tissue disorders. Currently, care for patients with SS is palliative, as no established therapeutics target the disease directly, and its pathogenetic mechanisms remain uncertain. B-cell abnormalities have been identified in SS. CXCL13 directs B-cell chemotaxis and is elevated in several autoimmune diseases. In this study, we tested the hypothesis that CXCL13 is elevated in SS in mice and humans and that neutralization of the chemokine ameliorates disease in a murine model. We assayed CXCL13 in mouse models and human subjects with SS to determine whether CXCL13 is elevated both locally and systemically during SS progression and whether CXCL13 may play a role in and be a biomarker for the disease. Cxcl13 expression in salivary tissue increases with disease progression, and its blockade resulted in a modest reduction in glandular inflammation in an SS model. We demonstrate that in humans CXCL13 is elevated in serum and saliva, and an elevated salivary CXCL13 level distinguishes patients with xerostomia. These data suggest a role for CXCL13 as a valuable biomarker in SS, as 74% of patients with SS displayed elevated CXCL13 in sera, saliva, or both. Thus, CXCL13 may be pathogenically involved in SS and may serve as a new marker and a potential therapeutic target.<\/jats:p>","DOI":"10.1189\/jlb.0113036","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T04:39:52Z","timestamp":1375331992000},"page":"1079-1089","source":"Crossref","is-referenced-by-count":116,"title":["CXCL13 is elevated in Sj\u00f6gren's syndrome in mice and humans and is implicated in disease pathogenesis"],"prefix":"10.1093","volume":"94","author":[{"given":"Jill M","family":"Kramer","sequence":"first","affiliation":[{"name":"Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research , Manhasset, New York, USA"},{"name":"Division of Oral and Maxillofacial Pathology, Department of Dental Medicine , New Hyde Park, New York, USA"},{"name":"Department of Dental Medicine, Hofstra North Shore-LIJ School of Medicine , Hempstead, New York, USA"},{"name":"Department of Oral Biology, State University at New York at Buffalo School of Dental Medicine , Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Klimatcheva","sequence":"additional","affiliation":[{"name":"Vaccinex, Incorporated , Rochester, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L","family":"Rothstein","sequence":"additional","affiliation":[{"name":"Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research , Manhasset, New York, USA"},{"name":"Department of Medicine, Hofstra North Shore-LIJ School of Medicine , Hempstead, New York, USA"},{"name":"Department of Molecular Medicine, Hofstra North Shore-LIJ School of Medicine , Hempstead, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1136\/ard.2009.110619","article-title":"EULAR Sj\u00f6gren's syndrome disease activity index: development of a consensus systemic disease activity index for primary Sj\u00f6gren's syndrome","volume":"69","author":"Seror","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"2023032711570227900_","first-page":"726","article-title":"Raynaud's phenomenon in primary Sj\u00f6gren's syndrom: prevalence and clinical characteristics in a series of 320 patients","volume":"29","author":"Garc\u00eda-Carrasco","year":"2002","journal-title":"J. Rheumatol."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1182\/blood-2007-10-119974","article-title":"Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium","volume":"111","author":"Ekstr\u00f6m Smedby","year":"2008","journal-title":"Blood"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","article-title":"Sj\u00f6gren's syndrome","volume":"366","author":"Fox","year":"2005","journal-title":"Lancet"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sj\u00f6gren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group","volume":"61","author":"Vitali","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/acr.21591","article-title":"American College of Rheumatology classification criteria for Sj\u00f6gren's syndrome: a data-driven, expert consensus approach in the Sj\u00f6gren's International Collaborative Clinical Alliance cohort","volume":"64","author":"Shiboski","year":"2012","journal-title":"Arthritis Care Res."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1477-7525-7-46","article-title":"Primary Sj\u00f6gren's syndrome: health experiences and predictors of health quality among patients in the United States","volume":"7","author":"Segal","year":"2009","journal-title":"Health Qual. Life. Outcomes"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1002\/eji.200737296","article-title":"Reciprocal generation of Th1\/Th17 and T(reg) cells by B1 and B2 B cells","volume":"37","author":"Zhong","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbspin.2007.07.001","article-title":"Sj\u00f6gren's syndrome: a quintessential B cell-induced autoimmune disease","volume":"75","author":"Youinou","year":"2008","journal-title":"Joint Bone Spine"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/art.20276","article-title":"Abnormalities in peripheral B cell memory of patients with primary Sj\u00f6gren's syndrome","volume":"50","author":"Hansen","year":"2004","journal-title":"Arthritis Rheum."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.4049\/jimmunol.167.7.3610","article-title":"Bm1-Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sj\u00f6gren's syndrome","volume":"167","author":"Bohnhorst","year":"2001","journal-title":"J. Immunol."},{"key":"2023032711570227900_","volume-title":"Ann. Rheum. Dis.","author":"Binard","year":"2008"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0896-8411(88)90025-X","article-title":"CD5-expressing B lymphocytes in the blood and salivary glands of patients with primary Sj\u00f6gren's syndrome","volume":"1","author":"Youinou","year":"1988","journal-title":"J. Autoimmun."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/art.1780330329","article-title":"B cells expressing CD5 in minor labial salivary glands of patients with primary Sj\u00f6gren's syndrome","volume":"33","author":"Zeher","year":"1990","journal-title":"Arthritis Rheum."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1210\/er.2006-0044","article-title":"Role of chemokines in endocrine autoimmune diseases","volume":"28","author":"Rotondi","year":"2007","journal-title":"Endocr. Rev."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/art.21129","article-title":"Dysregulation of chemokine receptor expression and function by B cells of patients with primary Sj\u00f6gren's syndrome","volume":"52","author":"Hansen","year":"2005","journal-title":"Arthritis Rheum."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1002\/art.23966","article-title":"Mature antigen-experienced T helper cells synthesize and secrete the B cel chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint","volume":"58","author":"Manzo","year":"2008","journal-title":"Arthritis Rheum."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/35876","article-title":"A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1","volume":"391","author":"Gunn","year":"1998","journal-title":"Nature"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1034\/j.1600-065X.2000.00618.x","article-title":"Follicular stromal cells and lymphocyte homing to follicles","volume":"176","author":"Cyster","year":"2000","journal-title":"Immunol. Rev."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0092-8674(00)81798-5","article-title":"A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen","volume":"87","author":"Forster","year":"1996","journal-title":"Cell"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1074-7613(01)00257-6","article-title":"CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity","volume":"16","author":"Ansel","year":"2002","journal-title":"Immunity"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S1074-7613(00)80199-5","article-title":"BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis","volume":"12","author":"Luther","year":"2000","journal-title":"Immunity"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1212\/WNL.0b013e3181c5b457","article-title":"Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS","volume":"73","author":"Sellebjerg","year":"2009","journal-title":"Neurology"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/art.23667","article-title":"Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor","volume":"58","author":"Rioja","year":"2008","journal-title":"Arthritis Rheum."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3899\/jrheum.090450","article-title":"Serum BLC\/CXCL13 concentrations and renal expression of CXCL13\/CXCR5 in patients with systemic lupus erythematosus and lupus nephritis","volume":"37","author":"Lee","journal-title":"J. Rheumatol."},{"key":"2023032711570227900_","first-page":"G290","article-title":"Stimulation-induced changes in cytosolic calcium in rat parotid acini","volume":"253","author":"Nauntofte","year":"1987","journal-title":"Am. J. Physiol."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1002\/eji.200737461","article-title":"PD-L2 expression extends beyond dendritic cells\/macrophages to B1 cells enriched for V(H)11\/V(H)12 and phosphatidylcholine binding","volume":"37","author":"Zhong","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"5276","DOI":"10.4049\/jimmunol.176.9.5276","article-title":"CXCR5\/CXCL13 interaction is important for double-negative regulatory T cell homing to cardiac allografts","volume":"176","author":"Lee","year":"2006","journal-title":"J. Immunol."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.4049\/jimmunol.180.3.1938","article-title":"Activated renal macrophages are markers of disease onset and disease remission in lupus nephritis","volume":"180","author":"Schiffer","year":"2008","journal-title":"J. Immunol."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/art.20768","article-title":"CXCL13 neutralization reduces the severity of collagen-induced arthritis","volume":"52","author":"Zheng","year":"2005","journal-title":"Arthritis Rheum."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1186\/ar3313","article-title":"Sj\u00f6gren's syndrome: studying the disease in mice","volume":"13","author":"Delaleu","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"2023032711570227900_","first-page":"2019","volume-title":"Cytokine Reference","author":"Forster","year":"2000"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1875-595X.2000.tb00554.x","article-title":"Saliva in health and disease: an appraisal and update","volume":"50","author":"Sreebny","year":"2000","journal-title":"Int. Dent. J."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ajpath.2012.05.014","article-title":"Critical involvement of macrophage infiltration in the development of Sj\u00f6gren's Syndrome-associated dry eye","volume":"181","author":"Zhou","year":"2012","journal-title":"Am. J. Pathol."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1172\/JCI42213","article-title":"The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis","volume":"120","author":"Moreth","year":"2010","journal-title":"J. Clin. Invest."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J. Clin. Invest."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jaut.2012.01.002","article-title":"Pathogenesis of Sj\u00f6gren's syndrome: what we know and what we should learn","volume":"39","author":"Tzioufas","year":"2012","journal-title":"J. Autoimmun."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1084\/jem.189.2.403","article-title":"Lymphotoxin alpha\/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen","volume":"189","author":"Ngo","year":"1999","journal-title":"J. Exp. Med."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"R182","DOI":"10.1186\/ar3507","article-title":"Lymphotoxin-beta Receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sj\u00f6gren's syndrome","volume":"13","author":"Fava","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"R24","DOI":"10.1186\/ar2617","article-title":"Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sj\u00f6gren syndrome in salivary glands of non-obese diabetic mice","volume":"11","author":"Gatumu","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.4049\/jimmunol.0903710","article-title":"CXCL13 blockade disrupts B lymphocyte organization in tertiary lymphoid structures without altering B cell receptor bias or preventing diabetes in nonobese diabetic mice","volume":"185","author":"Henry","year":"2010","journal-title":"J. Immunol."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1530\/eje.0.1500225","article-title":"The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases","volume":"150","author":"Aust","year":"2004","journal-title":"Eur. J. Endocrinol."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"7676","DOI":"10.4049\/jimmunol.176.12.7676","article-title":"CXC chemokine ligand 13 plays a role in experimental autoimmune encephalomyelitis","volume":"176","author":"Bagaeva","year":"2006","journal-title":"J. Immunol."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1182\/blood-2005-06-2383","article-title":"The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis","volume":"108","author":"Meraouna","year":"2006","journal-title":"Blood"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1002\/eji.200425373","article-title":"Aberrant B1 cell migration into the thymus results in activation of CD4 T cells through its potent antigen-presenting activity in the development of murine lupus","volume":"34","author":"Sato","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"650","DOI":"10.4049\/jimmunol.166.1.650","article-title":"Lymphoid chemokine B cell-attracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patients","volume":"166","author":"Shi","year":"2001","journal-title":"J. Immunol."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"R194","DOI":"10.1186\/ar3523","article-title":"Proteomic analysis of saliva: a unique tool to distinguish primary Sj\u00f6gren's syndrome from secondary Sj\u00f6gren's syndrome and other sicca syndromes","volume":"13","author":"Baldini","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1002\/pmic.201200208","article-title":"Quantitative proteomics of parotid saliva in primary Sj\u00f6gren's syndrome","volume":"12","author":"Ambatipudi","year":"2012","journal-title":"Proteomics"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/0022034510390811","article-title":"Salivary anti-Ro60 and anti-Ro52 antibody profiles to diagnose Sj\u00f6gren's Syndrome","volume":"90","author":"Ching","year":"2011","journal-title":"J. Dent. Res."},{"key":"2023032711570227900_","volume-title":"Ann. Rheum. Dis.","author":"Brkic","year":"2012"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jaut.2010.06.012","article-title":"Activation of the type I interferon pathway in primary Sj\u00f6gren's syndrome","volume":"35","author":"Mavragani","year":"2010","journal-title":"J. Autoimmun."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1073\/pnas.0510837103","article-title":"Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sj\u00f6gren's syndrome","volume":"103","author":"Gottenberg","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/ar3318","article-title":"Aspects of innate immunity in Sj\u00f6gren's syndrome","volume":"13","author":"Low","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.tripleo.2011.01.040","article-title":"Genetics and genomics of Sj\u00f6gren's syndrome: research provides clues to pathogenesis and novel therapies","volume":"111","author":"Segal","year":"2011","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/labinvest.3700487","article-title":"Early pathogenic events associated with Sj\u00f6gren's syndrome (SjS)-like disease of the NOD mouse using microarray analysis","volume":"86","author":"Killedar","year":"2006","journal-title":"Lab. Invest."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1172\/JCI0214121","article-title":"Association of BAFF\/BLyS overexpression and altered B cell differentiation with Sj\u00f6gren's syndrome","volume":"109","author":"Groom","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/01.LAB.0000059930.92336.E2","article-title":"Attenuated apoptosis of B cell activating factor-expressing cells in primary Sj\u00f6gren's syndrome","volume":"83","author":"Szodoray","year":"2003","journal-title":"Lab. Invest."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1182\/blood-2007-03-081232","article-title":"BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells","volume":"111","author":"Badr","year":"2008","journal-title":"Blood"},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/art.22458","article-title":"Aberrant expression of BAFF by B lymphocytes infiltrating the salivary glands of patients with primary Sj\u00f6gren's syndrome","volume":"56","author":"Daridon","year":"2007","journal-title":"Arthritis Rheum."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1186\/ar2210","article-title":"B cells in Sj\u00f6gren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue","volume":"9","author":"Hansen","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/BOR.0b013e32835707e4","article-title":"Updates on B-cell immunotherapies for systemic lupus erythematosus and Sj\u00f6gren's syndrome","volume":"24","author":"Coca","year":"2012","journal-title":"Curr. Opin. Rheumatol."},{"key":"2023032711570227900_","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1002\/art.30381","article-title":"Associations between salivary gland histopathologic diagnoses and phenotypic features of Sj\u00f6gren's syndrome among 1, 726 registry participants","volume":"63","author":"Daniels","year":"2011","journal-title":"Arthritis Rheum."}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1189%2Fjlb.0113036","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/94\/5\/1079\/49581739\/jlb1079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/94\/5\/1079\/49581739\/jlb1079.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T21:10:51Z","timestamp":1715807451000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/94\/5\/1079\/6936338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,1]]},"references-count":62,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,11,1]]},"published-print":{"date-parts":[[2013,11,1]]}},"URL":"https:\/\/doi.org\/10.1189\/jlb.0113036","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2013,11]]},"published":{"date-parts":[[2013,11,1]]}}}