{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:17:31Z","timestamp":1789996651987,"version":"4.0.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2004,10,21]],"date-time":"2004-10-21T00:00:00Z","timestamp":1098316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018992","name":"Fonds der Chemischen Industrie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB620"],"award-info":[{"award-number":["SFB620"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010752","name":"Institut f\u00fcr Klinische Immunologie und Transfusionsmedizin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009091","name":"Universit\u00e4tsklinikum Giessen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The killer cell lectin-like receptor G1 (KLRG1) is expressed in natural killer (NK) cells and effector memory \u03b1\u03b2 T cells. \u03b3\u03b4 T cells represent an unconventional lymphocyte population that shares characteristics of NK cells and T cells and links innate and adaptive immunity. V\u03b39\/V\u03b42 T cells comprise the majority of peripheral human \u03b3\u03b4 T cells and respond to the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP). Here, we demonstrate that KLRG1 is expressed in a significant proportion of V\u03b39\/V\u03b42 T cells in cord blood and in the majority of peripheral V\u03b39\/V\u03b42 T cells from adult donors. KLRG1+ V\u03b39\/V\u03b42 T cells displayed an effector memory phenotype, as KLRG1 was expressed mainly in V\u03b39\/V\u03b42 T cells lacking CD27, CD45RA, CD62L, and CC chemokine receptor 7 (CCR7). Unlike \u03b1\u03b2 T cells, where possession of KLRG1 identified effector memory cells with impaired proliferative capacity, KLRG1+ V\u03b39\/V\u03b42 T cells were able to proliferate vigorously upon stimulation with HMB-PP in the presence of interleukin-2. Moreover, KLRG1 ligation on V\u03b39\/V\u03b42 T cells by antibodies did not inhibit HMB-PP-induced proliferation and cytokine production nor cytolysis of Daudi cells.<\/jats:p>","DOI":"10.1189\/jlb.0204096","type":"journal-article","created":{"date-parts":[[2004,10,21]],"date-time":"2004-10-21T20:14:15Z","timestamp":1098389655000},"page":"67-70","source":"Crossref","is-referenced-by-count":31,"title":["Human V\u03b39\/V\u03b42 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1)"],"prefix":"10.1093","volume":"77","author":[{"given":"Matthias","family":"Eberl","sequence":"first","affiliation":[{"name":"Biochemisches Institut, Infektiologie, Justus-Liebig-Universit\u00e4t Giessen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosel","family":"Engel","sequence":"additional","affiliation":[{"name":"Biochemisches Institut, Infektiologie, Justus-Liebig-Universit\u00e4t Giessen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Aberle","sequence":"additional","affiliation":[{"name":"Pathologisches Institut, Molekulare Pathologie , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fisch","sequence":"additional","affiliation":[{"name":"Pathologisches Institut, Molekulare Pathologie , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Jomaa","sequence":"additional","affiliation":[{"name":"Biochemisches Institut, Infektiologie, Justus-Liebig-Universit\u00e4t Giessen , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter","family":"Pircher","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Mikrobiologie und Hygiene, Immunologie, Albert-Ludwigs-Universit\u00e4t Freiburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,10,21]]},"reference":[{"key":"2023033023035044300_","doi-asserted-by":"crossref","first-page":"6451","DOI":"10.4049\/jimmunol.161.12.6451","article-title":"Virus-activated CD8 T cells and lymphokine-activated NK cells express the mast cell function-associated antigen, an inhibitory C-type lectin","volume":"161","author":"Blaser","year":"1998","journal-title":"J. Immunol."},{"key":"2023033023035044300_","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1002\/(SICI)1521-4141(199812)28:12<4409::AID-IMMU4409>3.0.CO;2-3","article-title":"2F1 antigen, the mouse homolog of the rat \u201cmast cell function-associated antigen\u201d, is a lectin-like type II transmembrane receptor expressed by natural killer cells","volume":"28","author":"Hanke","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"2023033023035044300_","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s002510000282","article-title":"Genomic structure, alternative splicing, and physical mapping of the killer cell lectin-like receptor G1 gene (KLRG1), the mouse homologue of MAFA","volume":"52","author":"Voehringer","year":"2001","journal-title":"Immunogenetics"},{"key":"2023033023035044300_","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.4049\/jimmunol.168.6.2585","article-title":"Inhibitory functions of the killer cell lectin-like receptor G1 molecule during the activation of mouse NK cells","volume":"168","author":"Robbins","year":"2002","journal-title":"J. Immunol."},{"key":"2023033023035044300_","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1002\/1521-4141(200112)31:12<3443::AID-IMMU3443>3.0.CO;2-J","article-title":"Expression of inhibitory \u201ckiller cell lectin-like receptor G1\u201d identifies unique subpopulations of effector and memory CD8 T cells","volume":"31","author":"Beyersdorf","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"2023033023035044300_","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.4049\/jimmunol.167.9.4838","article-title":"Viral infections induce abundant numbers of senescent CD8 T cells","volume":"167","author":"Voehringer","year":"2001","journal-title":"J. Immunol."},{"key":"2023033023035044300_","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1002\/(SICI)1521-4141(199811)28:11<3755::AID-IMMU3755>3.0.CO;2-3","article-title":"MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells","volume":"28","author":"Butcher","year":"1998","journal-title":"Eur. J. 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Immunol."},{"key":"2023033023035044300_","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.4049\/jimmunol.159.12.6009","article-title":"CD94\/NKG2 inhibitory receptor complex modulates both anti-viral and anti-tumoral responses of polyclonal phosphoantigen-reactive V\u03b39V\u03b42 T lymphocytes","volume":"159","author":"Poccia","year":"1997","journal-title":"J. Immunol."},{"key":"2023033023035044300_","doi-asserted-by":"crossref","first-page":"7190","DOI":"10.4049\/jimmunol.166.12.7190","article-title":"Production of TNF-\u03b1 by human V\u03b39V\u03b42 T cells via engagement of Fc\u03b3RIIIA, the low affinity type 3 receptor for the Fc portion of IgG, expressed upon TCR activation by nonpeptidic antigen","volume":"166","author":"Lafont","year":"2001","journal-title":"J. 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Immunol."},{"key":"2023033023035044300_","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.4049\/jimmunol.168.3.1484","article-title":"Lack of CD27\u2013CD45RA\u2013 V\u03b39V\u03b42+ T cell effectors in immunocompromised hosts and during active pulmonary tuberculosis","volume":"168","author":"Gioia","year":"2002","journal-title":"J. Immunol."},{"key":"2023033023035044300_","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.4049\/jimmunol.170.12.5876","article-title":"Differential regulation of killer cell lectin-like receptor G1 expression on T cells","volume":"170","author":"Robbins","year":"2003","journal-title":"J. Immunol."},{"key":"2023033023035044300_","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1084\/jem.20030235","article-title":"Differentiation of effector\/memory V\u03b42 T cells and migratory routes in lymph nodes or inflammatory sites","volume":"198","author":"Dieli","year":"2003","journal-title":"J. Exp. 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