{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:02:17Z","timestamp":1761894137818,"version":"3.37.3"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2005,6,16]],"date-time":"2005-06-16T00:00:00Z","timestamp":1118880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK35527"],"award-info":[{"award-number":["DK35527"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe granulomatous eperimental autoimmune thyroiditis (G-EAT) in DBA\/1 or CBA\/J wild type (WT) mice at day 19 progresses to fibrosis by day 35, but severe G-EAT in DBA\/1 interferon (IFN)-\u03b3\u2212\/\u2212 mice or less-severe G-EAT at day 19 in WT mice resolves by day 35. To study the role of chemokines in autoimmune diseases and fibrosis, profiles of chemokines and chemokine receptors were analyzed in DBA\/1 WT versus IFN-\u03b3\u2212\/\u2212 and CBA\/J thyroids, which have distinct outcomes of autoimmune inflammation. Gene expression of CXC chemokine ligand 1 (CXCL1) and CXC chemokine receptor 2 (CXCR2) paralleled neutrophil infiltration and thyrocyte destruction in DBA\/1 WT or CBA\/J thyroids, and gene expression of CC chemokine ligand 11 (CCL11), CCL8, and CC chemokine receptor 3 paralleled eosinophil infiltration in IFN-\u03b3\u2212\/\u2212 thyroids. Gene and protein expression of CXCL10, CXCL9, and CXCR3 was significantly lower in IFN-\u03b3\u2212\/\u2212 compared with DBA\/1 WT thyroids. Moreover, immunostaining showed that CXCL10 was expressed by thyrocytes and inflammatory cells, and strong expression of CXCL10 by thyrocytes was as early as day 7. High expression of CCL2 was only observed in severely destroyed DBA\/1 WT or CBA\/J thyroids, which would develop fibrosis. Thus, the differential expression of chemokines may direct distinct cellular populations in DBA\/1 WT versus IFN-\u03b3\u2212\/\u2212 thyroids. Up-regulation of CXCL10 by thyrocytes suggests its role in regulating the recruitment of specific subsets of activated lymphocytes to the thyroid during autoimmune inflammation. The early expression of CXCL1, CXCL10, and CCL2 may suggest their involvement in the initiation and perpetuation of disease in severe G-EAT thyroids, which progress to fibrosis.<\/jats:p>","DOI":"10.1189\/jlb.0205102","type":"journal-article","created":{"date-parts":[[2005,6,17]],"date-time":"2005-06-17T00:54:52Z","timestamp":1118969692000},"page":"716-724","source":"Crossref","is-referenced-by-count":14,"title":["Chemokine expression during development of fibrosis versus resolution in a murine model of granulomatous experimental autoimmune thyroiditis"],"prefix":"10.1093","volume":"78","author":[{"given":"Kemin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Missouri School of Medicine , Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Missouri School of Medicine , Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Alter","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Missouri School of Medicine , Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon C","family":"Sharp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Missouri School of Medicine , Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Braley-Mullen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Missouri School of Medicine , Columbia"},{"name":"Department of Molecular Microbiology & Immunology, University of Missouri School of Medicine , Columbia"},{"name":"Department of VA Research Service , Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,6,16]]},"reference":[{"key":"2023033022474772000_","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.4049\/jimmunol.164.5.2759","article-title":"IFN-{\u03b3}shapes immune invasion of the central nervous system via regulation of chemokines","volume":"164","author":"Tran","year":"2000","journal-title":"J. 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