{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:40:08Z","timestamp":1780105208227,"version":"3.54.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2011,6,17]],"date-time":"2011-06-17T00:00:00Z","timestamp":1308268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007652","name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Investiga\u00e7\u00e3o em Imunologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007652","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,17]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Neutrophils are considered the host's first line of defense against infections and have been implicated in the immunopathogenesis of Leishmaniasis. Leishmania parasites are inoculated alongside vectors' saliva, which is a rich source of pharmacologically active substances that interfere with host immune response. In the present study, we tested the hypothesis that salivary components from Lutzomyia longipalpis, an important vector of visceral Leishmaniasis, enhance neutrophil apoptosis. Murine inflammatory peritoneal neutrophils cultured in the presence of SGS presented increased surface expression of FasL and underwent caspase-dependent and FasL-mediated apoptosis. This proapoptosis effect of SGS on neutrophils was abrogated by pretreatment with protease as well as preincubation with antisaliva antibodies. Furthermore, in the presence of Leishmania chagasi, SGS also increased apoptosis on neutrophils and increased PGE2 release and decreased ROS production by neutrophils, while enhancing parasite viability inside these cells. The increased parasite burden was abrogated by treatment with z-VAD, a pan caspase inhibitor, and NS-398, a COX-2 inhibitor. In the presence of SGS, Leishmania-infected neutrophils produced higher levels of MCP-1 and attracted a high number of macrophages by chemotaxis in vitro assays. Both of these events were abrogated by pretreatment of neutrophils with bindarit, an inhibitor of CCL2\/MCP-1 expression. Taken together, our data support the hypothesis that vector salivary proteins trigger caspase-dependent and FasL-mediated apoptosis, thereby favoring Leishmania survival inside neutrophils, which may represent an important mechanism for the establishment of Leishmania infection.<\/jats:p>","DOI":"10.1189\/jlb.0211105","type":"journal-article","created":{"date-parts":[[2011,6,18]],"date-time":"2011-06-18T02:55:44Z","timestamp":1308365744000},"page":"575-582","source":"Crossref","is-referenced-by-count":48,"title":["<i>Lutzomyia longipalpis<\/i>saliva drives apoptosis and enhances parasite burden in neutrophils"],"prefix":"10.1093","volume":"90","author":[{"given":"Deboraci Brito","family":"Prates","sequence":"first","affiliation":[{"name":"Centro de Pesquisa Gon\u00e7alo Moniz (CPqGM)-Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ) , Salvador, Brazil"},{"name":"Universidade Federal da Bahia , Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9o","family":"Ara\u00fajo-Santos","sequence":"additional","affiliation":[{"name":"Centro de Pesquisa Gon\u00e7alo Moniz (CPqGM)-Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ) , Salvador, Brazil"},{"name":"Universidade Federal da Bahia , Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00edvea Farias","family":"Luz","sequence":"additional","affiliation":[{"name":"Centro de Pesquisa Gon\u00e7alo Moniz (CPqGM)-Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ) , Salvador, Brazil"},{"name":"Universidade Federal da Bahia , Salvador, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno B","family":"Andrade","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Besthesda, Maryland, 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Pathol."},{"key":"2023033004525787100_","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1128\/IAI.73.9.5827-5834.2005","article-title":"Toward a novel experimental model of infection to study American cutaneous leishmaniasis caused by Leishmania braziliensis","volume":"73","author":"De Moura","year":"2005","journal-title":"Infect. Immun."},{"key":"2023033004525787100_","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0165-2478(98)00099-6","article-title":"The role of polymorphonuclear leukocytes in the resistance to cutaneous Leishmaniasis","volume":"64","author":"Lima","year":"1998","journal-title":"Immunol. Lett."},{"key":"2023033004525787100_","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0001-706X(91)90046-M","article-title":"Granulocytes in the inflammatory process of BALB\/c mice infected by Leishmania amazonensis. 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Immunol."},{"key":"2023033004525787100_","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.pt.2009.08.003","article-title":"Are neutrophils important host cells for Leishmania parasites?","volume":"25","author":"Ritter","year":"2009","journal-title":"Trends Parasitol."},{"key":"2023033004525787100_","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1155\/S0962935194000177","article-title":"Modulation of Leishmania (L.) amazonensis growth in cultured mouse macrophages by prostaglandins and platelet activating factor","volume":"3","author":"Lonardoni","year":"1994","journal-title":"Mediators Inflamm."},{"key":"2023033004525787100_","doi-asserted-by":"crossref","first-page":"34528","DOI":"10.1074\/jbc.M110.125302","article-title":"Selective fusion of azurophilic granules with Leishmania-containing phagosomes in human neutrophils","volume":"285","author":"Mollinedo","year":"2010","journal-title":"J. Biol. 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