{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:58:10Z","timestamp":1791226690634,"version":"4.1.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"publisher","award":["R37 AI26918"],"award-info":[{"award-number":["R37 AI26918"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI30663"],"award-info":[{"award-number":["R01 AI30663"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"publisher","award":["PPG HL107202"],"award-info":[{"award-number":["PPG HL107202"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"UCSF Sandler Asthma Basic Research Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Arg1 is produced by AAMs and is proposed to have a regulatory role during asthma and allergic inflammation. Here, we use an Arg1 reporter mouse to identify additional cellular sources of the enzyme in the lung. We demonstrate that ILC2s express Arg1 at rest and during infection with the migratory helminth Nippostrongylus brasiliensis. In contrast to AAMs, which express Arg1 following IL-4\/IL-13-mediated STAT6 activation, ILC2s constitutively express the enzyme in a STAT6-independent manner. Although ILC2s deficient in the IL-33R subunit T1\/ST2 maintain Arg1 expression, IL-33 can regulate total lung Arg1 by expanding the ILC2 population and by activating macrophages indirectly via STAT6. Finally, we find that ILC2 Arg1 does not mediate ILC2 accumulation, ILC2 production of IL-5 and IL-13, or collagen production during N. brasiliensis infection. Thus, ILC2s are a novel source of Arg1 in resting tissue and during allergic inflammation.<\/jats:p>","DOI":"10.1189\/jlb.0213084","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T01:58:55Z","timestamp":1375927135000},"page":"877-884","source":"Crossref","is-referenced-by-count":96,"title":["Type 2 innate lymphoid cells constitutively express arginase-I in the na\u00efve and inflamed lung"],"prefix":"10.1093","volume":"94","author":[{"given":"Jennifer K","family":"Bando","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of California-San Francisco , California, USA"},{"name":"Department of Medicine and University of California-San Francisco , California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse C","family":"Nussbaum","sequence":"additional","affiliation":[{"name":"Department of Medicine and University of California-San Francisco , California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Erh","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of California-San Francisco , California, USA"},{"name":"Department of Medicine and University of California-San Francisco , California, USA"},{"name":"Howard Hughes Medical Institute, University of California-San Francisco , California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M","family":"Locksley","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of California-San Francisco , California, USA"},{"name":"Department of Medicine and University of California-San Francisco , California, USA"},{"name":"Howard Hughes Medical Institute, University of California-San Francisco , California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"2023032711182840900_","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.nutr.22.110801.140547","article-title":"Regulation of enzymes of the urea cycle and arginine metabolism","volume":"22","author":"Morris","year":"2002","journal-title":"Annu. 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