{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:43:02Z","timestamp":1778661782618,"version":"3.51.4"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T00:00:00Z","timestamp":1366588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Bl 425\/2-3"],"award-info":[{"award-number":["Bl 425\/2-3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"5 per mille dell'IRPEF-Finanziamento della Ricerca Sanitaria"},{"name":"Finanziamento Ricerca Corrente"},{"DOI":"10.13039\/501100005010","name":"AIRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MFAG"},{"DOI":"10.13039\/501100007076","name":"Fondazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,4,22]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>OMS is a rare paraneoplastic disorder that affects adults and children. Pediatric OMS is often associated with NB, a common, solid tumor of childhood, derived from the sympathetic nervous system. The detection of autoantibodies and lymphocytic infiltration in NB patients led to advance an autoimmune hypothesis for the pathogenesis of OMS-related NB. BAFF is a potent modulator of B cell growth and survival upon interaction with its receptors BAFF-R and BCMA. The aim of this study was to investigate mechanism(s) involved in ectopic lymphoid neogenesis in OMS-associated NB. We investigated BAFF, BAFF-R, and BCMA expression in NB tumors associated or not with OMS. Furthermore, we evaluated BAFF expression and secretion in NB cell lines, treated or untreated with differentiating agents. Immunohistochemically, lymphocytes infiltrating NB tumors from patients, with or without OMS, expressed BAFF, BAFF-R, and BCMA, whereas neuroblasts expressed BAFF and BCMA but not BAFF-R. By flow cytometry, BAFF was found to be consistently expressed in NB cell lines. Similarly to the results obtained in tissue lesions, BCMA but not BAFF-R was detected on the surface of all NB cell lines under basal conditions. De novo synthesis of BAFF-R and up-regulation of BCMA were observed in NB cell lines upon treatment with IFN-\u03b3 or 13-cis retinoic acid. This study provides new insights in the mechanisms driving the neogenesis of lymphoid follicles and in the functional interactions between tumor and immune cells in OMS-associated NB.<\/jats:p>","DOI":"10.1189\/jlb.0213106","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T08:26:33Z","timestamp":1366705593000},"page":"183-191","source":"Crossref","is-referenced-by-count":13,"title":["Role of BAFF in Opsoclonus-Myoclonus syndrome, a bridge between cancer and autoimmunity"],"prefix":"10.1093","volume":"94","author":[{"given":"Lizzia","family":"Raffaghello","sequence":"first","affiliation":[{"name":"Laboratorie of Oncology, Istituto Giannina Gaslini , Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verena","family":"Fuhlhuber","sequence":"additional","affiliation":[{"name":"Justus-Liebig-University , Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Laboratorie of Oncology, Istituto Giannina Gaslini , Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Conte","sequence":"additional","affiliation":[{"name":"Department of Hematology-Oncology, Istituto Giannina Gaslini , Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Blaes","sequence":"additional","affiliation":[{"name":"Justus-Liebig-University , Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Gambini","sequence":"additional","affiliation":[{"name":"Laboratorie of Pathology, Istituto Giannina Gaslini , Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Pistoia","sequence":"additional","affiliation":[{"name":"Laboratorie of Oncology, Istituto Giannina Gaslini , Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,4,22]]},"reference":[{"key":"2023013012333397100_B1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrc1255","article-title":"Paraneoplastic neurological degenerations: keys to tumour immunity","volume":"4","author":"Albert","year":"2004","journal-title":"Nat. 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