{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:11:31Z","timestamp":1790363491178,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ministero della Sanit\u00e0 and from Associazione per la Ricerca sul Cancro","award":["#1\/RF99.18"],"award-info":[{"award-number":["#1\/RF99.18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Several chemokines have been shown to regulate cellular apoptosis following discrete stimuli. It was previously demonstrated that the CC chemokine CCL1 (I-309) rescues thymic lymphoma cells from apoptois by unknown mechanisms. The aim of our study was to characterize the role of the CC chemokine receptor 8 (CCR8), the only described receptor for CCL1, in the rescue of murine thymic lymphoma cells and murine thymocytes from dexamethasone (dex)-induced apoptosis. We show here that the CCR8-restricted agonist Kaposi sarcoma-associated herpesvirus-encoded chemokine viral macrophage-inflammatory protein-1 (vMIP-1) rescues thymic lymphoma cells from dex-induced apoptosis, similar to CCL1, and that such rescue is extracellular-regulated kinase-dependent. Although it has been hypothesized that the rescuing effect of CCL1 from apoptosis could be CCR8-mediated, here, we formally demonstrate the role of such receptor as its selective antagonist encoded by the MC148 gene of molluscum contagiosum virus MC148\/vMCC-I inhibits v-MIP-1- and CCL1-induced rescue activity. In addition, CCR8 ligands inhibit dex-induced apoptosis of murine thymocytes with potential implications for thymic selection.<\/jats:p>","DOI":"10.1189\/jlb.0302105","type":"journal-article","created":{"date-parts":[[2003,3,21]],"date-time":"2003-03-21T22:23:20Z","timestamp":1048285400000},"page":"201-207","source":"Crossref","is-referenced-by-count":46,"title":["The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway"],"prefix":"10.1093","volume":"73","author":[{"given":"Gaia","family":"Spinetti","sequence":"first","affiliation":[{"name":"Laboratorio di Patologia Vascolare, Istituto Dermopatico dell\u2019Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) , Rome , Italy"},{"name":"Department of Experimental Medicine and Pathology, University of Rome , \u201cLa Sapienza,\u201d \u00a0 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Bernardini","sequence":"additional","affiliation":[{"name":"Laboratorio di Patologia Vascolare, Istituto Dermopatico dell\u2019Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) , Rome , Italy"},{"name":"Department of Experimental Medicine and Pathology, University of Rome , \u201cLa Sapienza,\u201d \u00a0 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Camarda","sequence":"additional","affiliation":[{"name":"Laboratorio di Patologia Vascolare, Istituto Dermopatico dell\u2019Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Mangoni","sequence":"additional","affiliation":[{"name":"Laboratorio di Patologia Vascolare, Istituto Dermopatico dell\u2019Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Santoni","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine and Pathology, University of Rome , \u201cLa Sapienza,\u201d \u00a0 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio C","family":"Capogrossi","sequence":"additional","affiliation":[{"name":"Laboratorio di Patologia Vascolare, Istituto Dermopatico dell\u2019Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Laboratorio di Patologia Vascolare, Istituto Dermopatico dell\u2019Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) , Rome , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,1,1]]},"reference":[{"key":"2023033019051093100_jlb0201-cit-B1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.immunol.18.1.309","article-title":"Glucocorticoids in T cell development and function","volume":"18","author":"Ashwell","year":"2000","journal-title":"Annu. 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Agonist and antagonist profiles of viral chemokines","volume":"274","author":"Dairaghi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2023033019051093100_jlb0201-cit-B24","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.4049\/jimmunol.161.10.5111","article-title":"Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells","volume":"161","author":"D\u2019Ambrosio","year":"1998","journal-title":"J. Immunol."},{"key":"2023033019051093100_jlb0201-cit-B25","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1084\/jem.193.5.573","article-title":"Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice","volume":"193","author":"Chensue","year":"2001","journal-title":"J. Exp. Med."},{"key":"2023033019051093100_jlb0201-cit-B26","doi-asserted-by":"crossref","first-page":"6946","DOI":"10.1128\/JVI.74.15.6946-6952.2000","article-title":"CCR8 on human thymocytes functions as a human immunodeficiency virus type 1 coreceptor","volume":"74","author":"Lee","year":"2000","journal-title":"J. Virol."},{"key":"2023033019051093100_jlb0201-cit-B27","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.4049\/jimmunol.143.9.2907","article-title":"A novel polypeptide secreted by activated human T lymphocytes","volume":"143","author":"Miller","year":"1989","journal-title":"J. Immunol."},{"key":"2023033019051093100_jlb0201-cit-B28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1182\/blood.V97.1.39","article-title":"The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvius-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium","volume":"97","author":"Haque","year":"2001","journal-title":"Blood"},{"key":"2023033019051093100_jlb0201-cit-B29","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1182\/blood.V98.4.1150","article-title":"Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309","volume":"98","author":"Ruckes","year":"2001","journal-title":"Blood"},{"key":"2023033019051093100_jlb0201-cit-B30","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1073\/pnas.89.7.2950","article-title":"The human I-309 is a monocyte chemoattractant","volume":"89","author":"Miller","year":"1992","journal-title":"Proc. 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Immunol."},{"key":"2023033019051093100_jlb0201-cit-B34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1084\/jem.191.1.171","article-title":"A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum","volume":"191","author":"Luttichau","year":"2000","journal-title":"J. Exp. Med."},{"key":"2023033019051093100_jlb0201-cit-B35","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1182\/blood.V91.12.4434","article-title":"Differential chemotactic behavior of developing T cells in response to thymic chemokines","volume":"91","author":"Kim","year":"1998","journal-title":"Blood"},{"key":"2023033019051093100_jlb0201-cit-B36","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4049\/jimmunol.166.1.218","article-title":"The transient expression of C-C chemokine receptor 8 in thymus identifies a thymocyte subset committed to become CD4+ single-positive T cells","volume":"166","author":"Kremer","year":"2001","journal-title":"J. Immunol."},{"key":"2023033019051093100_jlb0201-cit-B37","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/jlb.66.6.996","article-title":"The murine chemokine receptor CXCR4 is tightly regulated during T cell development and activation","volume":"66","author":"Schabath","year":"1999","journal-title":"J. Leukoc. Biol."},{"key":"2023033019051093100_jlb0201-cit-B38","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1182\/blood.V93.10.3233.410k33_3233_3240","article-title":"Human thymocytes express CCR-3 and are activated by eotaxin","volume":"93","author":"Franz-Bacon","year":"1999","journal-title":"Blood"},{"key":"2023033019051093100_jlb0201-cit-B39","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1074\/jbc.273.1.386","article-title":"The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains","volume":"273","author":"Horuk","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2023033019051093100_jlb0201-cit-B40","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1182\/blood.V98.4.925","article-title":"Blocking of c-FLIPL-independent cycloheximide-induced apoptosis or Fas-mediated apoptosis by the CC chemokine receptor 9\/TECK interaction","volume":"98","author":"Youn","year":"2001","journal-title":"Blood"},{"key":"2023033019051093100_jlb0201-cit-B41","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.4049\/jimmunol.161.3.1239","article-title":"IL-4-producing NK1.1+ T cells are resistant to glucocorticoid-induced apoptosis: implications for the Th1\/Th2 balance","volume":"161","author":"Tamada","year":"1998","journal-title":"J. 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