{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:06:41Z","timestamp":1768565201598,"version":"3.49.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T00:00:00Z","timestamp":1248825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pronex"},{"DOI":"10.13039\/501100006507","name":"Fiocruz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CCL2 controls heart inflammation and parasite burden in Trypanosoma cruzi infection through cell recruitment and activation.<\/jats:p>\n               <jats:p>CCL2\/MCP-1 has emerged recently as a critical factor in infectious and autoimmune myocarditis. In fact, this chemokine is produced in great amounts in hearts from Trypanosoma cruzi-infected mice and is known to enhance parasite uptake and destruction by macrophages. Herein, we studied the involvement of CCL2 in tissue inflammation and resistance to T. cruzi. Infected CCL2\u2212\/\u2212 mice developed higher parasitemias and died earlier than WT mice. Close to their death, T. cruzi-infected CCL2\u2212\/\u2212 presented greater amounts of TNF, IFN-\u03b3, and IL-10 in plasma than WTs and clinical signs of systemic inflammatory response. Amastigote nests were more frequent in hearts and livers from infected CCL2\u2212\/\u2212 tissues than in WTs, and reduced numbers of leukocytes infiltrated their tissues. Leukocytes formed diffuse but not focal infiltrates in hearts from infected CCL2\u2212\/\u2212 mice, and perivascular cuffs could still be found in their livers. Infected CCL2\u2212\/\u2212 mice had smaller percentages of activated CD11b (Mac-1)+CD107b (Mac-3)+ macrophages and CD8+CD69hi cells among heart and liver infiltrates than WTs (flow cytometry), indicating that CCL2 controls subset migration\/activation. CCL2 accumulated among focal heart infiltrates, suggesting that this chemokine is involved in retention of mononuclear cells in particular spots. Peritoneal macrophages from CCL2\u2212\/\u2212 mice displayed decreased trypanocidal activity. Our results demonstrate that CCL2 contributes to reduce parasite growth and indicate that it does so by controlling the distribution, cellular composition, and state of activation of inflammatory infiltrates in acute T. cruzi infection.<\/jats:p>","DOI":"10.1189\/jlb.0309187","type":"journal-article","created":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T01:06:37Z","timestamp":1248915997000},"page":"1239-1246","source":"Crossref","is-referenced-by-count":39,"title":["CCL2\/MCP-1 controls parasite burden, cell infiltration, and mononuclear activation during acute <i>Trypanosoma cruzi<\/i> infection"],"prefix":"10.1093","volume":"86","author":[{"given":"Cl\u00e1udia N","family":"Paiva","sequence":"first","affiliation":[{"name":"Departamentos de Imunologia, Instituto de Microbiologia Prof Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo T","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Departamentos de Imunologia, Instituto de Microbiologia Prof Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Kroll-Palhares","sequence":"additional","affiliation":[{"name":"Departamentos de Laborat\u00f3rio de Pesquisa em Auto-imunidade e Imuno-regula\u00e7\u00e3o, Instituto Oswaldo Cruz , Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea A","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamentos de Laborat\u00f3rio de Pesquisa em Auto-imunidade e Imuno-regula\u00e7\u00e3o, Instituto Oswaldo Cruz , Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaline C","family":"Silv\u00e9rio","sequence":"additional","affiliation":[{"name":"Departamentos de Laborat\u00f3rio de Pesquisa em Auto-imunidade e Imuno-regula\u00e7\u00e3o, Instituto Oswaldo Cruz , Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Gibaldi","sequence":"additional","affiliation":[{"name":"Departamentos de Imunologia, Instituto de Microbiologia Prof Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro , Brazil"},{"name":"Departamentos de Laborat\u00f3rio de Pesquisa em Auto-imunidade e Imuno-regula\u00e7\u00e3o, Instituto Oswaldo Cruz , Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre dos S","family":"Pyrrho","sequence":"additional","affiliation":[{"name":"Departamentos de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade Federal do Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia F","family":"Benjamim","sequence":"additional","affiliation":[{"name":"Departamentos de Farmacologia B\u00e1sica e Clinica, Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseli","family":"Lannes-Vieira","sequence":"additional","affiliation":[{"name":"Departamentos de Laborat\u00f3rio de Pesquisa em Auto-imunidade e Imuno-regula\u00e7\u00e3o, Instituto Oswaldo Cruz , Fiocruz, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo T","family":"Bozza","sequence":"additional","affiliation":[{"name":"Departamentos de Imunologia, Instituto de Microbiologia Prof Paulo de G\u00f3es, Universidade Federal do Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,7,29]]},"reference":[{"key":"2023032912525544300_jlb1239-cit-b1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.immunol.26.021607.090326","article-title":"Monocyte- mediated defense against microbial pathogens","volume":"26","author":"Serbina","year":"2008","journal-title":"Annu. 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