{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:26:06Z","timestamp":1792704366041,"version":"4.5.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T00:00:00Z","timestamp":1317081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["CA100062"],"award-info":[{"award-number":["CA100062"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["CD84488"],"award-info":[{"award-number":["CD84488"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005567","name":"H. Lee Moffitt Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005567","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012415","name":"Biomedical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012415","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,9,27]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>MDSCs are a group of cells with potent immune-suppressive activity. These cells accumulate in many pathologic conditions and play a major role in the regulation of immune responses. The nature of MDSC remains highly debatable. In cancer, most MDSCs are represented by cells with granulocytic phenotype and morphology, G-MDSC. The relationship between G-MDSCs and Neu remains unclear. In this study, we have found that G-MDSCs, from tumor-bearing, and Neu, from tumor-free, mice share a common morphology and phenotype. However, in contrast to Neu, a substantial proportion of G-MDSCs expressed M-CSFR and a CD244 molecule. Neu had significantly higher phagocytic activity, expression of lysosomal proteins, and TNF-\u03b1 than corresponding G-MDSCs, which had significantly higher activity of arginase, MPO, and ROS. In contrast to G-MDSC, neither rested nor mobilized Neu suppressed T cells. G-MDSC survived 2 days in culture in the presence of GM-CSF and within 24 h, became phenotypic and functionally similar to Neu. Tumor-associated G-MDSC shared most characteristics of splenic G-MDSC, rather then Neu. These data suggest that in cancer, despite morphological and phenotypic similarities, G-MDSCs are functionally distinct from Neu and are comprised of pathologically activated precursors of Neu.<\/jats:p>","DOI":"10.1189\/jlb.0311177","type":"journal-article","created":{"date-parts":[[2011,9,28]],"date-time":"2011-09-28T05:48:11Z","timestamp":1317188891000},"page":"167-181","source":"Crossref","is-referenced-by-count":470,"title":["Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice"],"prefix":"10.1093","volume":"91","author":[{"given":"Je-In","family":"Youn","sequence":"first","affiliation":[{"name":"H. Lee Moffitt Cancer Center , Tampa, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Collazo","sequence":"additional","affiliation":[{"name":"H. Lee Moffitt Cancer Center , Tampa, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina N","family":"Shalova","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network (A*STAR) , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhra K","family":"Biswas","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network (A*STAR) , Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry I","family":"Gabrilovich","sequence":"additional","affiliation":[{"name":"H. 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