{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:01:43Z","timestamp":1790787703208,"version":"4.1.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30972754"],"award-info":[{"award-number":["30972754"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CD56+ T cells, through the secretion of IFN-\u03b3, enhance the expression of IRFs and STATs, resulting in the induction of intracellular IFN-\u03b1\/\u03b2 and APOBEC3G\/3F.<\/jats:p>\n               <jats:p>CD56+ T cells, the crucial component of the host innate immune system, play an important role in defense against viral infections. We investigated the noncytolytic anti-HIV-1 activity of primary CD56+ T cells. SNs collected from CD56+ T cell cultures inhibited HIV-1 infection and replication. This CD56+ T SN-mediated anti-HIV-1 activity was broad-spectrum, as CD56+ T SNs could inhibit infections by laboratory-adapted and clinical strains of HIV-1. The antibody to IFN-\u03b3 could partially block the CD56+ T SN-mediated anti-HIV effect. Investigation of mechanism(s) of the CD56+ T cell action on HIV-1 showed that although CD56+ T SN had little effect on HIV-1 entry coreceptor CCR5 expression, CD56+ T SN induced the expression of CC-chemokines, the ligands for CCR5. The antibodies to CC-chemokines also significantly blocked CD56+ T SN-mediated anti-HIV activity. Furthermore, CD56+ T SN up-regulated the expression of STAT-1\/-2 and enhanced the expression of IRF1, -3, -7, and -9, resulting in the induction of endogenous IFN-\u03b1\/\u03b2 expression in macrophages. Moreover, CD56+ T SN up-regulated intracellular expression of APOBEC3G\/3F, the recently identified HIV-1 restriction factors. These findings provide compelling evidence that CD56+ T cells may have a critical role in innate immunity against HIV-1 infection.<\/jats:p>","DOI":"10.1189\/jlb.0312146","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T17:07:25Z","timestamp":1337274445000},"page":"343-351","source":"Crossref","is-referenced-by-count":11,"title":["CD56+ T cells inhibit HIV-1 infection of macrophages"],"prefix":"10.1093","volume":"92","author":[{"given":"Wei","family":"Hou","sequence":"first","affiliation":[{"name":"Animal Biosafety Level 3 Laboratory\/Center for Animal Experiment, Wuhan University , Wuhan, P. R. China"},{"name":"State Key Laboratory of Virology\/Institute of Medical Virology, School of Basic Medical Science, Wuhan University , Wuhan, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ye","sequence":"additional","affiliation":[{"name":"Animal Biosafety Level 3 Laboratory\/Center for Animal Experiment, Wuhan University , Wuhan, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Zhe","family":"Ho","sequence":"additional","affiliation":[{"name":"Animal Biosafety Level 3 Laboratory\/Center for Animal Experiment, Wuhan University , Wuhan, P. R. China"},{"name":"Department of Pathology and Laboratory Medicine, Temple University School of Medicine , Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,8,1]]},"reference":[{"key":"2023012312543594600_B1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0065-2776(08)60665-3","article-title":"The immunopathogenesis of HIV infection","volume":"47","author":"Rosenberg","year":"1989","journal-title":"Adv. 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