{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:37:25Z","timestamp":1761154645811,"version":"3.37.3"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2004,7,16]],"date-time":"2004-07-16T00:00:00Z","timestamp":1089936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY05093"],"award-info":[{"award-number":["EY05093"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,7,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Herpetic stromal keratitis (HSK) is a T cell-orchestrated, immunoinflammatory lesion that results from corneal Herpes simplex virus infection. Previous reports indicate an essential role for proinflammatory cytokine interleukin (IL)-1 in HSK pathogenesis. The present study evaluates the efficacy of IL-1 receptor antagonist (IL-1 ra) protein in the management of HSK. Mice receiving IL-1 ra had diminished disease severity. The administration of IL-1 ra was shown to reduce the influx into the cornea of cells of the innate and adaptive immune response. In addition, the treatment diminished corneal vascular endothelial growth factor levels, resulting in reduced angiogenic response. Our results show the importance of targeting early proinflammatory molecules such as IL-1 to counteract HSK and advocate IL-1 ra as an effective agent to achieve this.<\/jats:p>","DOI":"10.1189\/jlb.0504280","type":"journal-article","created":{"date-parts":[[2004,7,17]],"date-time":"2004-07-17T00:52:50Z","timestamp":1090025570000},"page":"868-875","source":"Crossref","is-referenced-by-count":21,"title":["Counteracting corneal immunoinflammatory lesion with interleukin-1 receptor antagonist protein"],"prefix":"10.1093","volume":"76","author":[{"given":"Partha Sarathi","family":"Biswas","sequence":"first","affiliation":[{"name":"Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee , Knoxville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaustuv","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee , Knoxville"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, Medical College of Georgia , Augusta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry T","family":"Rouse","sequence":"additional","affiliation":[{"name":"Comparative and Experimental Medicine, College of Veterinary Medicine, University of Tennessee , Knoxville"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,7,16]]},"reference":[{"key":"2023033100001068900_","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0167-5699(97)01114-6","article-title":"Immunity causing blindness: five different paths to herpes stromal keratitis","volume":"18","author":"Streilein","year":"1997","journal-title":"Immunol. 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