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Whereas stabilin-1 is expressed in sinusoidal endothelial cells and in macrophages in vivo, stabilin-2 is absent from the latter. In the present study, we analyzed the subcellular distribution of stabilin-1 in primary human macrophages. Using flow cytometry, expression of stabilin-1 was demonstrated on the surface of interleukin-4\/dexamethasone-stimulated macrophages (M\u03a62). By immunofluorescense and confocal microscopy, we established that stabilin-1 is preferentially localized in early endosome antigen-1-positive early\/sorting endosomes and in recycling endosomes identified by transferrin endocytosis. Association of stabilin-1 was infrequently seen with p62 lck ligand-positive late endosomes and with CD63-positive lysosomes but not in lysosome-associated membrane protein-1-positive lysosomes. Stabilin-1 was also found in the trans-Golgi network (TGN) but not in Golgi stack structures. Glutathione S-transferase pull-down assay revealed that the cytoplasmic tail of stabilin-1 but not stabilin-2 binds to recently discovered Golgi-localized, \u03b3-ear-containing, adenosine 5\u2032-diphosphate-ribosylation factor-binding (GGA) adaptors GGA1, GGA2, and GGA3 long, mediating traffic between Golgi and endosomal\/lysosomal compartments. Stabilin-1 did not bind to GGA3 short, which lacks a part of the Vps27p\/Hrs\/STAM domain. Deletion of DDSLL and LL amino acid motifs resulted in decreased binding of stabilin-1 with GGAs. A small portion of stabilin-1 colocalized with GGA2 and GGA3 in the TGN in M\u03a62. Treatment with brefeldin A resulted in accumulation of stabilin-1 in the TGN. Our results suggest that stabilin-1 is involved in the GGA-mediated sorting processes at the interface of the biosynthetic and endosomal pathways; similarly to other GGA-interacting proteins, stabilin-1 may thus function in endocytic and secretory processes of human macrophages.<\/jats:p>","DOI":"10.1189\/jlb.0504300","type":"journal-article","created":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T00:15:32Z","timestamp":1094170532000},"page":"1151-1161","source":"Crossref","is-referenced-by-count":73,"title":["Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors"],"prefix":"10.1093","volume":"76","author":[{"given":"Julia","family":"Kzhyshkowska","sequence":"first","affiliation":[{"name":"Department of Dermatology, University Medical Centre Mannheim, Ruprecht-Karls University Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Gratchev","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Centre Mannheim, Ruprecht-Karls University Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Henning","family":"Martens","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Centre Mannheim, Ruprecht-Karls University Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Pervushina","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Centre Mannheim, Ruprecht-Karls University Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Mamidi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Centre Mannheim, Ruprecht-Karls University Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology, University of Uppsala , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Schledzewski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Centre Mannheim, Ruprecht-Karls University Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Centre Mannheim, Ruprecht-Karls University Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyuan","family":"He","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation , Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Tang","sequence":"additional","affiliation":[{"name":"Oklahoma Medical Research Foundation , Oklahoma City"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Kyoto University , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergij","family":"Goerdt","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Centre Mannheim, Ruprecht-Karls University Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,9,2]]},"reference":[{"key":"2023033023454856100_","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1042\/bj3620155","article-title":"Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologues","volume":"362","author":"Politz","year":"2002","journal-title":"Biochem. 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