{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:45:25Z","timestamp":1787021125658,"version":"build-2736575974"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2005,10,21]],"date-time":"2005-10-21T00:00:00Z","timestamp":1129852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute of Drug Abuse","doi-asserted-by":"crossref","award":["DA07908"],"award-info":[{"award-number":["DA07908"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000026","name":"National Institute of Drug Abuse","doi-asserted-by":"crossref","award":["DA016828"],"award-info":[{"award-number":["DA016828"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We have reported previously that \u03949-tetrahydrocannabinol (\u03949-THC) treatment of resting human and murine splenic T cells robustly elevated intracellular calcium ([Ca2+]i). The objective of the present investigation was to examine the putative role of [Ca2+]i store depletion and store-operated calcium (SOC) [1] and receptor-operated cation (ROC) channels in the mechanism by which \u03949-THC increases [Ca2+]i in the cannabinoid-2 receptor-expressing human peripheral blood-acute lymphoid leukemia (HPB-ALL) human T cell line. By using the smooth endoplasmic reiculum Ca2+-ATPase pump inhibitor, thapsigargin, and the ryanodine receptor antagonist, 8-bromo-cyclic adenosine diphosphate ribose, we demonstrate that the \u03949-THC-mediated elevation in [Ca2+]i occurs independently of [Ca2+]i store depletion. Furthermore, the ROC channel inhibitor, SK&amp;F 96365 was more efficacious at attenuating the \u03949-THC-mediated elevation in [Ca2+]i than SOC channel inhibitors, 2-aminoethoxydiphenyl borate and La3+. Recently, several members of the transient receptor potential canonical (TRPC) channel subfamily have been suggested to operate as SOC or ROC channels. In the present studies, treatment of HPB-ALL cells with 1-oleoyl-2-acetyl-sn-glycerol (OAG), a cell-permeant analog of diacylglycerol (DAG), which gates several members of the TRPC channel subfamily, rapidly elevated [Ca2+]i, as well as prevented a subsequent, additive elevation in [Ca2+]i by \u03949-THC, independent of protein kinase C. Reverse transcriptase-polymerase chain reaction analysis for TRPC1\u20137 showed that HPB-ALL cells express detectable mRNA levels of only TRPC1. Finally, small interference RNA knockdown of TRPC1 attenuated the \u03949-THC-mediated elevation of [Ca2+]i. Collectively, these results suggest that \u03949-THC-induced elevation in [Ca2+]i is attributable entirely to extracellular calcium influx, which is independent of [Ca2+]i store depletion, and is mediated, at least partially, through the DAG-sensitive TRPC1 channels.<\/jats:p>","DOI":"10.1189\/jlb.0505274","type":"journal-article","created":{"date-parts":[[2005,10,26]],"date-time":"2005-10-26T04:23:06Z","timestamp":1130300586000},"page":"202-213","source":"Crossref","is-referenced-by-count":37,"title":["Induction of intracellular calcium elevation by \u03949-tetrahydrocannabinol in T cells involves TRPC1 channels"],"prefix":"10.1093","volume":"79","author":[{"given":"Gautham K","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Pharmacology & Toxicology, Center for Integrative Toxicology, and National Food Safety & Toxicology Center, Michigan State University , East Lansing"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert E","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, Center for Integrative Toxicology, and National Food Safety & Toxicology Center, Michigan State University , East Lansing"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,10,21]]},"reference":[{"key":"2023033022240993200_jlb0202-cit-1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0162-3109(93)90005-B","article-title":"\u03949-Tetrahydrocanabinol selectively inhibits T-cell dependent humoral immune responses through direct inhibition of accessory T-cell function","volume":"26","author":"Schatz","year":"1993","journal-title":"Immunopharmacology"},{"key":"2023033022240993200_jlb0202-cit-2","doi-asserted-by":"crossref","first-page":"13175","DOI":"10.1074\/jbc.271.22.13175","article-title":"Cannabinoid inhibition of adenylate cyclase-mediated signal transduction and interleukin 2 (IL-2) expression in the murine T-cell line, EL4.IL-2","volume":"271","author":"Condie","year":"1996","journal-title":"J. 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