{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T08:34:19Z","timestamp":1759826059868},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Neutrophil apoptosis in meningococcal meningitis is controlled by TNF-\u03b1 and depends on functional PI3-kinase signaling in monocytes.<\/jats:p>\n               <jats:p>In bacterial meningitis, neutrophils cope with bacterial infection but also lead to tissue damage. The balance of beneficial and harmful effects may depend on the lifespan of the neutrophils in the CNS. Here, we show that CSF of patients with meningococcal meningitis contains a neutrophil apoptosis-inhibiting capacity that correlates with TNF-\u03b1 content. In vitro experiments show that Neisseria meningitidis as well as LPS derived from these bacteria regulated neutrophil apoptosis mainly by stimulating TNF-\u03b1 production in monocytes. Whereas LPS-induced PI3K-dependent survival signals in monocytes are critical for neutrophil survival, PI3K signaling in granulocytes did not contribute to the increased lifespan of neutrophils. We conclude that LPS-driven PI3K signaling in monocytes regulates neutrophil apoptosis and thereby, may be crucial in the initiation of secondary brain damage in bacterial meningitis.<\/jats:p>","DOI":"10.1189\/jlb.0511218","type":"journal-article","created":{"date-parts":[[2012,11,9]],"date-time":"2012-11-09T02:11:24Z","timestamp":1352427084000},"page":"259-266","source":"Crossref","is-referenced-by-count":5,"title":["Inhibition of meningitis-associated neutrophil apoptosis by TNF-\u03b1 depends on functional PI3-kinase in monocytes"],"prefix":"10.1093","volume":"93","author":[{"given":"Mike","family":"Recher","sequence":"first","affiliation":[{"name":"Clinical Immunology, University Hospital, University of Z\u00fcrich , Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Malipiero","sequence":"additional","affiliation":[{"name":"Clinical Immunology, University Hospital, University of Z\u00fcrich , Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik J","family":"Schaer","sequence":"additional","affiliation":[{"name":"Clinical Immunology, University Hospital, University of Z\u00fcrich , Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Koedel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ludwig-Maximilians University , Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Walter","family":"Pfister","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ludwig-Maximilians University , Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Birchler","sequence":"additional","affiliation":[{"name":"Institute for Experimental Immunology, University of Z\u00fcrich , Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Petrausch","sequence":"additional","affiliation":[{"name":"Clinical Immunology, University Hospital, University of Z\u00fcrich , Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Claus","sequence":"additional","affiliation":[{"name":"Institute for Hygiene and Microbiology, University of Wuerzburg , Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidemarie","family":"Gast","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital, University Hospital Berne, University of Berne , Berne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Fontana","sequence":"additional","affiliation":[{"name":"Institute for Experimental Immunology, University of Z\u00fcrich , Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"2023012312525761100_B1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1128\/CMR.00070-09","article-title":"Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis","volume":"23","author":"Brouwer","year":"2010","journal-title":"Clin. 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