{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:43:00Z","timestamp":1773409380433,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Contribution of SCF auto-production to neoplastic growth of mast cells.<\/jats:p>\n               <jats:p>Mastocytosis is a disease accompanied by the abnormal expansion and accumulation of mast cells. Although the D816V mutation is detected in most cases of systemic mastocytosis, the mutation is rarely observed in other forms of mastocytosis, such as cutaneous mastocytosis and mast cell leukemia\/sarcoma, for which the mechanism of tumorigenesis remains unknown. In this study, we demonstrated a novel mechanism of mast cell tumorigenesis via SCF autocrine\/paracrine release. SCF was highly expressed in a WT KIT-expressing HRMC line, contributing to the phosphorylation of KIT. Neutralization of external SCF using a neutralizing antibody or suppression of SCF production by RNA interference inhibited the growth of HRMC cells, indicating the essential role of SCF in cell proliferation. To the best of our knowledge, this is the first report to determine the significant contribution of SCF autoproduction to neoplastic proliferation of mast cells. These results indicate the possibility that targeting SCF production may become a novel treatment for mast cell malignancies.<\/jats:p>","DOI":"10.1189\/jlb.0512245","type":"journal-article","created":{"date-parts":[[2012,11,3]],"date-time":"2012-11-03T03:12:32Z","timestamp":1351912352000},"page":"245-250","source":"Crossref","is-referenced-by-count":15,"title":["Stem cell factor contributes to tumorigenesis of mast cells via an autocrine\/paracrine mechanism"],"prefix":"10.1093","volume":"93","author":[{"given":"Y","family":"Amagai","sequence":"first","affiliation":[{"name":"Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology , Tokyo, Japan"},{"name":"Medicinal Research Laboratories, Shionogi & Co. , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology , Tokyo, Japan"},{"name":"Laboratories of Comparative Animal Medicine, Tokyo University of Agriculture and Technology , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology , Tokyo, Japan"},{"name":"Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Tokyo University of Agriculture and Technology , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Jung","sequence":"additional","affiliation":[{"name":"Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Ohmori","sequence":"additional","affiliation":[{"name":"Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology , Tokyo, Japan"},{"name":"Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Tokyo University of Agriculture and Technology , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Cooperative Major in Advanced Health Science, Graduate School of Bio-Applications and System Engineering, Tokyo University of Agriculture and Technology , Tokyo, Japan"},{"name":"Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Tokyo University of Agriculture and Technology , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"2023012312525656400_B1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1586\/ehm.10.42","article-title":"Pathogenesis, classification and treatment of mastocytosis: state of the art in 2010 and future perspectives","volume":"3","author":"Arock","year":"2010","journal-title":"Expert Rev. 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