{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:39:22Z","timestamp":1790840362504,"version":"4.1.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100002794","name":"Swedish Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Torsten and Ragnar S\u00f6derberg\u02c8s Foundation"},{"name":"Inga-Britt and Arne Lundberg Research Foundation"},{"name":"Assar Gabrielsson\u02c8s Cancer Foundation"},{"name":"Gunvor and Ivan Svensson Foundation"},{"DOI":"10.13039\/501100007687","name":"Swedish Society of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Sahlgrenska Academy at University of Gothenburg"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CML cells induce PARP-1 dependent parthanatos in NK cells, and inhibition of PARP-1 maintains lymphocyte viability and function.<\/jats:p>\n                  <jats:p>NK cells and T cells are commonly dysfunctional in CML, and their status may determine the course of disease. We aimed to define the molecular mechanisms of leukemia-induced immunosuppression with focus on the role of ROS and the PARP-1 pathway of cell death. Malignant granulocytes from patients with BCR-ABL-positive CML expressed the oxygen radical-producing enzyme NOX, produced large amounts of ROS, and triggered extensive cell death in NK cells. Inhibition of PARP-1 maintained NK cell viability in cocultures with suppressive leukemic cells. Under conditions of oxidative stress, PARP-1 inhibition upheld the capacity of NK cells to kill myeloid leukemic cells, in addition to restoring the proliferation and cytokine production of NK cells and cytotoxic T cells. Our findings are suggestive of a novel pathway of relevance to immunosuppression in CML.<\/jats:p>","DOI":"10.1189\/jlb.0512257","type":"journal-article","created":{"date-parts":[[2012,10,17]],"date-time":"2012-10-17T02:14:53Z","timestamp":1350440093000},"page":"155-160","source":"Crossref","is-referenced-by-count":18,"title":["Chronic myeloid leukemic cells trigger poly(ADP-ribose) polymerase-dependent inactivation and cell death in lymphocytes"],"prefix":"10.1093","volume":"93","author":[{"given":"Johan","family":"Aurelius","sequence":"first","affiliation":[{"name":"Sahlgrenska Cancer Center, University of Gothenburg, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"},{"name":"Departments of Infectious Diseases, Section of Virology, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Martner","sequence":"additional","affiliation":[{"name":"Sahlgrenska Cancer Center, University of Gothenburg, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"},{"name":"Departments of Infectious Diseases, Section of Virology, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E","family":"Riise","sequence":"additional","affiliation":[{"name":"Sahlgrenska Cancer Center, University of Gothenburg, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"},{"name":"Departments of Infectious Diseases, Section of Virology, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana I","family":"Romero","sequence":"additional","affiliation":[{"name":"Departments of Infectious Diseases, Section of Virology, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Palmqvist","sequence":"additional","affiliation":[{"name":"Departments of Clinical Chemistry and Transfusion Medicine, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Brune","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Section of Hematology, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristoffer","family":"Hellstrand","sequence":"additional","affiliation":[{"name":"Sahlgrenska Cancer Center, University of Gothenburg, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"},{"name":"Departments of Infectious Diseases, Section of Virology, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik B","family":"Thor\u00e9n","sequence":"additional","affiliation":[{"name":"Sahlgrenska Cancer Center, University of Gothenburg, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"},{"name":"Departments of Infectious Diseases, Section of Virology, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"},{"name":"Departments of Internal Medicine, Section of Hematology, The Sahlgrenska Academy at University of Gothenburg , G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,1,1]]},"reference":[{"key":"2023012312523786000_B1","first-page":"117","article-title":"Susceptibility of human leukemia to allogeneic and autologous lymphokine-activated killer cell activity: analysis of 252 samples","volume":"11","author":"Teichmann","year":"1992","journal-title":"Nat. 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