{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:19:51Z","timestamp":1774563591511,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2003,9,2]],"date-time":"2003-09-02T00:00:00Z","timestamp":1062460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR42455"],"award-info":[{"award-number":["AR42455"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR48409"],"award-info":[{"award-number":["AR48409"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transforming growth factor-\u03b2 (TGF-\u03b2) has been considered an anti-inflammatory cytokine responsible for the bland removal of apoptotic cells. What is less established is the extent of secretion of this cytokine during the clearance of opsonized apoptotic cells via Fc\u03b3-mediated uptake. To date both decreased (favoring predominance of inflammation) and increased (favoring resolution of inflammation but potentially pro-fibrotic) responses have been demonstrated. In an in vitro model of autoantibody-induced cardiac injury, we herein demonstrate that macrophages cocultured with apoptotic human fetal cardiocytes bound by anti-SSA\/Ro antibodies secrete increased levels of TGF-\u03b2. Prolonged secretion of this cytokine may contribute to the exuberant scarring seen in congenital heart block associated with maternal autoantibodies reactive with SSA\/Ro and SSB\/La antigens.<\/jats:p>","DOI":"10.1189\/jlb.0603276","type":"journal-article","created":{"date-parts":[[2003,9,10]],"date-time":"2003-09-10T01:25:10Z","timestamp":1063157110000},"page":"959-960","source":"Crossref","is-referenced-by-count":34,"title":["Clearance of apoptotic cells: TGF-\u03b2 in the balance between inflammation and fibrosis"],"prefix":"10.1093","volume":"74","author":[{"given":"Robert M","family":"Clancy","sequence":"first","affiliation":[{"name":"Hospital for Joint Diseases, New York University School of Medicine, Department of Rheumatology , New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill P","family":"Buyon","sequence":"additional","affiliation":[{"name":"Hospital for Joint Diseases, New York University School of Medicine, Department of Rheumatology , New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,9,2]]},"reference":[{"key":"2023033100292820800_","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1189\/jlb.1202599","article-title":"Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD)","volume":"73","author":"Brown","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"2023033100292820800_","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1172\/JCI0211638","article-title":"Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation","volume":"109","author":"Huynh","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2023033100292820800_","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/35011084","article-title":"A receptor for phosphatidylserine-specific clearance of apoptotic cells","volume":"405","author":"Fadok","year":"2000","journal-title":"Nature"},{"key":"2023033100292820800_","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1126\/science.3487831","article-title":"Transforming growth factor-beta: biological function and chemical structure","volume":"233","author":"Sporn","year":"1986","journal-title":"Science"},{"key":"2023033100292820800_","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.4049\/jimmunol.169.4.2156","article-title":"Transdifferentiation of cardiac fibroblasts, a fetal factor in anti-SSA\/Ro-SSB\/La antibody-mediated congenital heart block","volume":"169","author":"Clancy","year":"2002","journal-title":"J. Immunol."},{"key":"2023033100292820800_","article-title":"Neonatal lupus syndrome","author":"Buyon","year":"2003","edition":"4th ed"},{"key":"2023033100292820800_","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1172\/JCI1112","article-title":"Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine\/paracrine mechanisms involving TGF-\u03b2, PGE2, and PAF","volume":"101","author":"Fadok","year":"1998","journal-title":"J. Clin. Invest."}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1189%2Fjlb.0603276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/74\/6\/959\/49657782\/jlb0959.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/74\/6\/959\/49657782\/jlb0959.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T18:16:55Z","timestamp":1734113815000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/74\/6\/959\/6976092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,2]]},"references-count":7,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2003,9,2]]},"published-print":{"date-parts":[[2003,12,1]]}},"URL":"https:\/\/doi.org\/10.1189\/jlb.0603276","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2003,12]]},"published":{"date-parts":[[2003,9,2]]}}}