{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:51:04Z","timestamp":1790754664992,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2004,3,12]],"date-time":"2004-03-12T00:00:00Z","timestamp":1079049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"The Deutsche Forschungsgemeinschaft, Clinical Research Group, \u201cGrowth Control of Neoplastic B-Cells,\u201d","award":["KFO 105\/1"],"award-info":[{"award-number":["KFO 105\/1"]}]},{"name":"European Community","award":["ERBFMBICT 983532"],"award-info":[{"award-number":["ERBFMBICT 983532"]}]},{"name":"European Community","award":["QLK2-CT-2001-01205 Memovax"],"award-info":[{"award-number":["QLK2-CT-2001-01205 Memovax"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite the important role immunoglobulin G (IgG)-secreting plasma cells play in memory immune responses, the differentiation and homeostasis of these cells are not completely understood. Here, we studied the differentiation of human IgG-secreting cells ex vivo and in vitro, identifying these cells by the cellular affinity matrix technology. Several subpopulations of IgG-secreting cells were identified among the cells isolated from tonsils and bone marrow, particularly differing in the expression levels of CD9, CD19, and CD38. CD38 low IgG-secreting cells were present exclusively in the tonsils. A major fraction of these cells appeared to be early plasma cell precursors, as upon activation of B cells in vitro, IgG secretion preceded up-regulation of CD38, and on tonsillar sections, IgG-containing, CD38 low cells with a plasmacytoid phenotype were found in follicles, where plasma cell differentiation starts. A unitary phenotype of migratory peripheral blood IgG-secreting cells suggests that all bone marrow plasma cell populations share a common precursor cell. These data are compatible with a multistep model for plasma cell differentiation and imply that a common CD38 low IgG-secreting precursor gives rise to a diverse plasma cell compartment.<\/jats:p>","DOI":"10.1189\/jlb.0603279","type":"journal-article","created":{"date-parts":[[2004,3,16]],"date-time":"2004-03-16T01:44:31Z","timestamp":1079401471000},"page":"1022-1028","source":"Crossref","is-referenced-by-count":77,"title":["CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations"],"prefix":"10.1093","volume":"75","author":[{"given":"Sergio","family":"Arce","sequence":"first","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Luger","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolin","family":"Muehlinghaus","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Cassese","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Hauser","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Horst","sequence":"additional","affiliation":[{"name":"Miltenyi Biotec GmbH, Bergisch Gladbach , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Lehnert","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Odendahl","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"H\u00f6nemann","sequence":"additional","affiliation":[{"name":"Charite\u2019 Humboldt University , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Dieter","family":"Heller","sequence":"additional","affiliation":[{"name":"Orthop\u00e4dische Klinik Braunschweig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Kleinschmidt","sequence":"additional","affiliation":[{"name":"Orthop\u00e4dische Klinik Braunschweig , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Berek","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"D\u00f6rner","sequence":"additional","affiliation":[{"name":"Charite\u2019 Humboldt University , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veit","family":"Krenn","sequence":"additional","affiliation":[{"name":"Charite\u2019 Humboldt University , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Hiepe","sequence":"additional","affiliation":[{"name":"Charite\u2019 Humboldt University , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Bargou","sequence":"additional","affiliation":[{"name":"Charite\u2019 Humboldt University , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Radbruch","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf A","family":"Manz","sequence":"additional","affiliation":[{"name":"Deutsches Rheuma-Forschungszentrum , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,3,12]]},"reference":[{"key":"2023033100110735300_","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1084\/jem.194.1.45","article-title":"A coordinated change in chemokine responsiveness guides plasma cell movements.","volume":"194","author":"Hargreaves","year":"2001","journal-title":"J. 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