{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:09:37Z","timestamp":1772003377750,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2006,2,24]],"date-time":"2006-02-24T00:00:00Z","timestamp":1140739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"MURST","award":["40%"],"award-info":[{"award-number":["40%"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,2,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The peroxisome proliferator-activated receptor-\u03b1 (PPAR-\u03b1) is a member of the nuclear receptor superfamily of ligand-dependent transcription factors related to retinoid, steroid, and thyroid hormone receptors. The aim of the present study was to evaluate the role of the PPAR-\u03b1 receptor on the development of acute inflammation. To address this question, we used two animal models of acute inflammation (carrageenan-induced paw edema and carrageenan-induced pleurisy). We report here that when compared with PPAR-\u03b1 wild-type mice, PPAR-\u03b1 knockout mice (PPAR-\u03b1KO) mice experienced a higher rate of the extent and severity when subjected to carrageenan injection in the paw edema model or to carrageenan administration in the pleurisy model. In particular, the absence of a functional PPAR-\u03b1 gene in PPAR-\u03b1KO mice resulted in a significant augmentation of various inflammatory parameters (e.g., enhancement of paw edema, pleural exudate formation, mononuclear cell infiltration, and histological injury) in vivo. Furthermore, the absence of a functional PPAR-\u03b1 gene enhanced the staining (immunohistochemistry) for FAS ligand in the paw and in the lung and the expression of tumor necrosis factor \u03b1 and interleukin-1\u03b2 in the lungs of carrageenan-treated mice. In conclusion, the increased inflammatory response observed in PPAR-\u03b1\u039a\u039f mice strongly suggests that a PPAR-\u03b1 pathway modulates the degree of acute inflammation in the mice.<\/jats:p>","DOI":"10.1189\/jlb.0605341","type":"journal-article","created":{"date-parts":[[2006,2,25]],"date-time":"2006-02-25T01:45:05Z","timestamp":1140831905000},"page":"999-1010","source":"Crossref","is-referenced-by-count":85,"title":["The role of the peroxisome proliferator-activated receptor-\u03b1 (PPAR-\u03b1) in the regulation of acute inflammation"],"prefix":"10.1093","volume":"79","author":[{"given":"Salvatore","family":"Cuzzocrea","sequence":"first","affiliation":[{"name":"Dipartment Clinical and Experimental Medicine and Pharmacology, Schoo of Medicine, University of Messina Torre Biologica, Policlinico Universitario , Italy"},{"name":"Centro per lo Studio edil Trattamento dei Neurolesi Lungodegenti, Facolt\u00e0 di Medicina e Chirurgia, University of Messina , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Mazzon","sequence":"additional","affiliation":[{"name":"Dipartment Clinical and Experimental Medicine and Pharmacology, Schoo of Medicine, University of Messina Torre Biologica, Policlinico Universitario , Italy"},{"name":"Centro per lo Studio edil Trattamento dei Neurolesi Lungodegenti, Facolt\u00e0 di Medicina e Chirurgia, University of Messina , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Di Paola","sequence":"additional","affiliation":[{"name":"Dipartment Clinical and Experimental Medicine and Pharmacology, Schoo of Medicine, University of Messina Torre Biologica, Policlinico Universitario , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Peli","sequence":"additional","affiliation":[{"name":"Clinical Veterinary Department Alma Mater Studiorum, University of Bologna , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bonato","sequence":"additional","affiliation":[{"name":"Clinical Veterinary Department Alma Mater Studiorum, University of Bologna , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Britti","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science, University of Teramo , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Genovese","sequence":"additional","affiliation":[{"name":"Dipartment Clinical and Experimental Medicine and Pharmacology, Schoo of Medicine, University of Messina Torre Biologica, Policlinico Universitario , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmelo","family":"Mui\u00e0","sequence":"additional","affiliation":[{"name":"Dipartment Clinical and Experimental Medicine and Pharmacology, Schoo of Medicine, University of Messina Torre Biologica, Policlinico Universitario , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Crisafulli","sequence":"additional","affiliation":[{"name":"Dipartment Clinical and Experimental Medicine and Pharmacology, Schoo of Medicine, University of Messina Torre Biologica, Policlinico Universitario , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achille P","family":"Caputi","sequence":"additional","affiliation":[{"name":"Dipartment Clinical and Experimental Medicine and Pharmacology, Schoo of Medicine, University of Messina Torre Biologica, Policlinico Universitario , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,2,24]]},"reference":[{"key":"2023033015240055500_jlb0999-cit-B1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1476-5381.1994.tb17048.x","article-title":"Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy","volume":"113","author":"Tomlinson","year":"1994","journal-title":"Br. 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