{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:55:25Z","timestamp":1790632525313,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T00:00:00Z","timestamp":1157587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Bone Growth Foundation"},{"name":"Channel-7 Children\u2019s Research Foundation of South Australia"},{"DOI":"10.13039\/501100000925","name":"Australian National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Injured growth plate cartilage is often repaired by bony tissue, resulting in impaired bone growth in children. Previously, injury-induced, initial inflammatory response was shown to be an acute inflammatory event containing predominantly neutrophils. To examine potential roles of neutrophils in the bony repair, a neutrophil-neutralizing antiserum or control normal serum was administered systemically in rats with growth plate injury. The inflammatory response was found temporally associated with increased expression of neutrophil chemotactic chemokine cytokine-induced neutrophil chemoattractant-1 and cytokines TNF-\u03b1 and IL-1\u03b2. Following the inflammatory response, mesenchymal infiltration, chondrogenic and osteogenic responses, and bony repair were observed at the injury site. Neutrophil reduction did not significantly affect infiltration of other inflammatory cells and expression of TNF-\u03b1 and IL-1\u03b2 and growth factors, platelet-derived growth factor-B and TGF-\u03b21, at the injured growth plate on Day 1 and had no effects on mesenchymal infiltration on Day 4. By Day 10, however, there was a significant reduction in proportion of mesenchymal repair tissue but an increase (although statistically insignificant) in bony trabeculae and a decrease in cartilaginous tissue within the injury site. Consistently, in antiserum-treated rats, there was an increase in expression of osteoblastic differentiation transcription factor cbf-\u03b11 and bone matrix protein osteocalcin and a decrease in chondrogenic transcription factor Sox-9 and cartilage matrix collagen-II in the injured growth plate. These results suggest that injury-induced, neutrophil-mediated inflammatory response appears to suppress mesenchymal cell osteoblastic differentiation but enhance chondrogenic differentiation, and thus, it may be involved in regulating downstream chondrogenic and osteogenic events for growth plate bony repair.<\/jats:p>","DOI":"10.1189\/jlb.0606365","type":"journal-article","created":{"date-parts":[[2006,9,7]],"date-time":"2006-09-07T20:45:25Z","timestamp":1157661925000},"page":"1272-1280","source":"Crossref","is-referenced-by-count":117,"title":["Roles of neutrophil-mediated inflammatory response in the bony repair of injured growth plate cartilage in young rats"],"prefix":"10.1093","volume":"80","author":[{"given":"Rosa","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Women\u2019s and Children\u2019s Hospital , North Adelaide, South Australia, Australia"},{"name":"Department of Pharmaceutical Biotechnology, University of South Australia , Adelaide, Australia"},{"name":"Department of Physiology, University of Adelaide , South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna C","family":"Cool","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Women\u2019s and Children\u2019s Hospital , North Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela A","family":"Scherer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Women\u2019s and Children\u2019s Hospital , North Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce K","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Women\u2019s and Children\u2019s Hospital , North Adelaide, South Australia, Australia"},{"name":"Department of Paediatrics and University of Adelaide , South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory J","family":"Xian","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Women\u2019s and Children\u2019s Hospital , North Adelaide, South Australia, Australia"},{"name":"Department of Pharmaceutical Biotechnology, University of South Australia , Adelaide, Australia"},{"name":"Department of Physiology, University of Adelaide , South Australia, Australia"},{"name":"Department of Paediatrics and University of Adelaide , South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,9,7]]},"reference":[{"key":"2023033007482474600_jlb1272-cit-B1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S1471-4914(02)02340-7","article-title":"Transcription factors in bone: developmental and pathological aspects","volume":"8","author":"Yang","year":"2002","journal-title":"Trends Mol. 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