{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:28:31Z","timestamp":1740137311399,"version":"3.37.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T00:00:00Z","timestamp":1294099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"European Community via the Marie Curie Action Miditrain","award":["MEST-CT-2004-504990"],"award-info":[{"award-number":["MEST-CT-2004-504990"]}]},{"DOI":"10.13039\/501100001659","name":"German Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kultusministerium of Niedersachsen via the Lichtenberg Ph.D. program"},{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Helmholtz Gemeinschaft via Helmholtz International Research School for Infection Biology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,1,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In the spleen, the MZ forms an interface between red and white pulp. Its major function is to trap blood-borne antigens and to reorient them to APCs and lymphocytes. SIGN-R1+ cells are of the MZ inherent cell population, which for a long time, have been considered as macrophages. We now show that one subpopulation of SIGN-R1+ cells that express MHC II molecules should be considered as a resident DC. Histological analysis indicated that SIGN-R1+ cells have dendritic-like protrusions extending into T and B cell areas. Flow cytometry analysis revealed an expression profile of adhesion, costimulatory, and MHC molecules similar to cDCs but distinct from macrophages. Most importantly, SIGN-R1+MHC+ cells were able to present antigen to na\u00efve CD4 T cells, as well as to cross-present soluble, particulate antigens secreted by Listeria monocytogenes to CD8 T cells in vitro and in vivo. Our experiments identified SIGN-R1+MHC II+ cells as professional APCs and indicate their nature as splenic resident DCs.<\/jats:p>","DOI":"10.1189\/jlb.0610368","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T01:35:43Z","timestamp":1294191343000},"page":"607-615","source":"Crossref","is-referenced-by-count":6,"title":["SIGN-R1+MHC II+ cells of the splenic marginal zone\u2014a novel type of resident dendritic cells"],"prefix":"10.1093","volume":"89","author":[{"given":"Marcin","family":"\u0141yszkiewicz","sequence":"first","affiliation":[{"name":"Department of Molecular Biotechnology, Molecular Immunology, HZI, Helmholtz Centre for Infection Research , Braunschweig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Zi\u0119tara","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology, Molecular Immunology, HZI, Helmholtz Centre for Infection Research , Braunschweig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Rohde","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology, Molecular Immunology, HZI, Helmholtz Centre for Infection Research , Braunschweig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson O","family":"Gekara","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology, Molecular Immunology, HZI, Helmholtz Centre for Infection Research , Braunschweig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadwiga","family":"Jab\u0142o\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology, Molecular Immunology, HZI, Helmholtz Centre for Infection Research , Braunschweig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt E","family":"Dittmar","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology, Molecular Immunology, HZI, Helmholtz Centre for Infection Research , Braunschweig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology, Molecular Immunology, HZI, Helmholtz Centre for Infection Research , Braunschweig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2011,1,4]]},"reference":[{"key":"2023032920210468900_","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1615\/CritRevImmunol.v24.i6.40","article-title":"Development and function of the splenic marginal zone","volume":"24","author":"Mebius","year":"2004","journal-title":"Crit. 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