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Despite similar levels of expression in macrophages, SLP-76 is not required for Fc receptor for immunoglobulin G (IgG; Fc\u03b3R)-mediated activation. We hypothesized that the related adaptor SLP-65, which is also expressed in macrophages, may compensate for the loss of SLP-76 during Fc\u03b3R-mediated signaling and functional events. To address this hypothesis, we examined bone marrow-derived macrophages (BMM) from wild-type (WT) mice or mice lacking both of these adaptors. Contrary to our expectations, SLP-76\u2212\/\u2212 SLP-65\u2212\/\u2212 BMM demonstrated normal Fc\u03b3R-mediated activation, including internalization of Ig-coated sheep red blood cells and production of reactive oxygen intermediates. Fc\u03b3R-induced biochemical events were normal in SLP-76\u2212\/\u2212 SLP-65\u2212\/\u2212 BMM, including phosphorylation of phospholipase C and the extracellular signaling-regulated kinases 1 and 2. To determine whether macrophages functioned normally in vivo, we infected WT and SLP-76\u2212\/\u2212 SLP-65\u2212\/\u2212 mice with sublethal doses of Listeria monocytogenes (LM), a bacterium against which the initial host defense is provided by activated macrophages. WT and SLP-76\u2212\/\u2212 SLP-65\u2212\/\u2212 mice survived acute, low-dose infection and showed no difference in the number of liver or spleen LM colony-forming units, a measure of the total body burden of this organism. Taken together, these data suggest that neither SLP-76 nor SLP-65 is required during Fc\u03b3R-dependent signaling and functional events in macrophages.<\/jats:p>","DOI":"10.1189\/jlb.0703312","type":"journal-article","created":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T01:12:50Z","timestamp":1072746770000},"page":"541-552","source":"Crossref","is-referenced-by-count":14,"title":["Macrophage activation and Fc\u03b3 receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors"],"prefix":"10.1093","volume":"75","author":[{"given":"Kim E","family":"Nichols","sequence":"first","affiliation":[{"name":"Pediatric Oncology, Children\u2019s Hospital of Philadelphia , Pennsylvania"},{"name":"Abramson Family Cancer Research Institute, University of Pennsylvania , Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Haines","sequence":"additional","affiliation":[{"name":"Pediatric Oncology, Children\u2019s Hospital of Philadelphia , Pennsylvania"},{"name":"Abramson Family Cancer Research Institute, University of Pennsylvania , Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy S","family":"Myung","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, University of Pennsylvania , Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally","family":"Newbrough","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, University of Pennsylvania , Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Myers","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, University of Pennsylvania , Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Jumaa","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Immunobiology , Freiburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon J","family":"Shedlock","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Pennsylvania , Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Pennsylvania , Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary A","family":"Koretzky","sequence":"additional","affiliation":[{"name":"Abramson Family Cancer Research Institute, University of Pennsylvania , Philadelphia"},{"name":"Department of Pathology and Laboratory Medicine, University of Pennsylvania , Philadelphia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,12,23]]},"reference":[{"key":"2023033100201660400_","doi-asserted-by":"crossref","first-page":"7029","DOI":"10.1074\/jbc.270.13.7029","article-title":"Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells","volume":"270","author":"Jackman","year":"1995","journal-title":"J. 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