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These cells are thought to help in regulating the inflammatory response. Until now, V\u03b36\/V\u03b41+ cells have only been detectable indirectly, by expression of V\u03b36-encoding mRNA. Here, we report that 17D1, a monoclonal antibody, which detects the related epidermis-associated V\u03b35\/V\u03b41+ TCR, will also bind the V\u03b36\/V\u03b41+ cells if their TCR is first complexed to an anti-C\u03b4 antibody. Features of this special condition for recognition suggest the possibility that an alternate structure exists for the V\u03b36\/V\u03b41 TCR, which is stabilized upon binding to the anti-C\u03b4 antibody. Using the 17D1 antibody as means to track this \u03b3\u03b4 T cell subset by flow cytometry, we discovered that the response of V\u03b36\/V\u03b41+ cells during inflammation often far exceeds that of other subsets and that the responding V\u03b36\/V\u03b41+ cells display a strikingly uniform activation\/memory phenotype compared with other \u03b3\u03b4 T cell subsets.<\/jats:p>","DOI":"10.1189\/jlb.0703326","type":"journal-article","created":{"date-parts":[[2003,10,7]],"date-time":"2003-10-07T00:16:07Z","timestamp":1065485767000},"page":"68-75","source":"Crossref","is-referenced-by-count":78,"title":["Subset-specific, uniform activation among V\u03b36\/V\u03b41+ \u03b3\u03b4 T cells elicited by inflammation"],"prefix":"10.1093","volume":"75","author":[{"given":"Christina L","family":"Roark","sequence":"first","affiliation":[{"name":"Integrated Department of Immunology, National Jewish Medical and Research Center , Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Kemal","family":"Aydintug","sequence":"additional","affiliation":[{"name":"Integrated Department of Immunology, National Jewish Medical and Research Center , Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yale University School of Medicine , New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Yin","sequence":"additional","affiliation":[{"name":"Integrated Department of Immunology, National Jewish Medical and Research Center , Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lahn","sequence":"additional","affiliation":[{"name":"Integrated Department of Immunology, National Jewish Medical and Research Center , Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn-Soo","family":"Hahn","sequence":"additional","affiliation":[{"name":"Integrated Department of Immunology, National Jewish Medical and Research Center , Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willi K","family":"Born","sequence":"additional","affiliation":[{"name":"Integrated Department of Immunology, National Jewish Medical and Research Center , Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E","family":"Tigelaar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yale University School of Medicine , New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Integrated Department of Immunology, National Jewish Medical and Research Center , Denver, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,10,2]]},"reference":[{"key":"2023033100221326400_","first-page":"1","article-title":"TCR and function co-segregate in \u03b3\u03b4 T cell subsets","author":"O\u2019Brien","year":"2001"},{"key":"2023033100221326400_","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1002\/eji.1830261240","article-title":"The canonical T cell receptor of dendritic epidermal \u03b3\u03b4 T cells is highly conserved between rats and mice","volume":"26","author":"Kuhnlein","year":"1996","journal-title":"Eur. 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