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It is interesting that a decrease in CD1d expression on splenic dendritic cells (DC) and macrophages (M\u03a6) was observed for at least 3 months post-LCMV infection, and vaccinia virus and vesicular stomatitis virus induced similar changes in CD1d upon infection with those viruses. The reduction of CD1d cell-surface expression on DC and M\u03a6 was independent of interferon-\u03b3 and interleukin-12 expression but partially recovered in transporter associated with antigen processing-1-deficient mice, suggesting that CD8+ T cells may play a role. Thus, one consequence of the induction of a cellular immune response is a change in CD1d expression, which may constitute a key element in regulating antiviral immunity.<\/jats:p>","DOI":"10.1189\/jlb.0704399","type":"journal-article","created":{"date-parts":[[2004,11,18]],"date-time":"2004-11-18T01:14:08Z","timestamp":1100740448000},"page":"151-158","source":"Crossref","is-referenced-by-count":32,"title":["Reduction in CD1d expression on dendritic cells and macrophages by an acute virus infection"],"prefix":"10.1093","volume":"77","author":[{"given":"Yinling","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, and The Walther Cancer Institute , Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonya J","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, and The Walther Cancer Institute , Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M","family":"Spence","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, and The Walther Cancer Institute , Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy R","family":"Brutkiewicz","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, The Walther Oncology Center, and The Walther Cancer Institute , Indianapolis"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,11,17]]},"reference":[{"key":"2023020710353137400_B1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.immunol.17.1.297","article-title":"The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids","volume":"17","author":"Porcelli","year":"1999","journal-title":"Annu. 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