{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:21:18Z","timestamp":1790904078750,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2005,1,24]],"date-time":"2005-01-24T00:00:00Z","timestamp":1106524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["#QLK2-1999-0014"],"award-info":[{"award-number":["#QLK2-1999-0014"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ecos-Anuies program","award":["PM990S01"],"award-info":[{"award-number":["PM990S01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,24]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human V\u03b39V\u03b42 T cells pay a crucial role in early immune response to intracellular pathogens. In brucellosis infection, this population of cells is drastically increased in the peripheral blood of patients during the acute phase of infection. In vitro, V\u03b39V\u03b42 T cells exhibit strong cytolytic activity against Brucella-infected cells and are able to impair intracellular growth of Brucella suis in autologous macrophages. In this study, we have investigated the relative importance of contact-dependent mechanisms versus soluble factors in the intracellular growth and viability of B. suis. We show that V\u03b39V\u03b42 T cells use contact-dependent mechanisms, such as the release of lytic granules and Fas-mediated signals, to decrease intracellular B. suis through lysis of infected macrophages, but these mechanisms have little impact on Brucella survival. Moreover, we demonstrate that soluble factors secreted by V\u03b39V\u03b42 T cells can directly affect B. suis survival through their potent bactericidal effects. From these results, we conclude that V\u03b39V\u03b42 T cells are able to use a combination of mechanisms that reduce the total numbers of B. suis and thus, may benefit the host by limiting the spread of this intracellular pathogen.<\/jats:p>","DOI":"10.1189\/jlb.0704433","type":"journal-article","created":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T01:25:43Z","timestamp":1106616343000},"page":"652-660","source":"Crossref","is-referenced-by-count":34,"title":["V\u03b39V\u03b42 T cells use a combination of mechanisms to limit the spread of the pathogenic bacteria Brucella"],"prefix":"10.1093","volume":"77","author":[{"given":"Jane","family":"Oliaro","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 431, Microbiologie et Pathologie Cellulaire Infectieuse, Universit\u00e9 de Montpellier II , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherri","family":"Dudal","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 431, Microbiologie et Pathologie Cellulaire Infectieuse, Universit\u00e9 de Montpellier II , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janny","family":"Liautard","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 431, Microbiologie et Pathologie Cellulaire Infectieuse, Universit\u00e9 de Montpellier II , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Andrault","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 431, Microbiologie et Pathologie Cellulaire Infectieuse, Universit\u00e9 de Montpellier II , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Liautard","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 431, Microbiologie et Pathologie Cellulaire Infectieuse, Universit\u00e9 de Montpellier II , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Lafont","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit\u00e9 431, Microbiologie et Pathologie Cellulaire Infectieuse, Universit\u00e9 de Montpellier II , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,1,24]]},"reference":[{"key":"2023033023021489200_","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0065-2776(08)60405-8","article-title":"Confrontation between intracellular bacteria and the immune system","volume":"71","author":"Schaible","year":"1999","journal-title":"Adv. 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