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Many of these models mimic the pathophysiology of human sepsis. However, identification of mediators in animals, the blockade of which has been protective, has not translated into clinical efficacy in septic humans. We describe the shortcomings of the animal models and reasons why effective therapy for human sepsis cannot be derived readily from promising findings in animal sepsis.<\/jats:p>","DOI":"10.1189\/jlb.0806542","type":"journal-article","created":{"date-parts":[[2006,10,5]],"date-time":"2006-10-05T00:36:39Z","timestamp":1160008599000},"page":"137-143","source":"Crossref","is-referenced-by-count":323,"title":["The disconnect between animal models of sepsis and human sepsis"],"prefix":"10.1093","volume":"81","author":[{"given":"Daniel","family":"Rittirsch","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School , Ann Arbor, Michigan , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Marco","family":"Hoesel","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School , Ann Arbor, Michigan , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School , Ann Arbor, Michigan , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,10,4]]},"reference":[{"key":"2023033007415425700_","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit. 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