{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:59:06Z","timestamp":1792069146042,"version":"4.4.0"},"reference-count":143,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,2,5]],"date-time":"2008-02-05T00:00:00Z","timestamp":1202169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","award":["MOP62908"],"award-info":[{"award-number":["MOP62908"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pre-B cell colony-enhancing factor (PBEF), also known as visfatin, is a highly conserved, 52-kDa protein found in living species from bacteria to humans. Originally a curiosity identified serendipitously in microarray studies but having no obvious functional importance, PBEF has now been shown to exert three distinct activities of central importance to cellular energetics and innate immunity. Within the cell, PBEF functions as a nicotinamide phosphoribosyl transferase, the rate-limiting step in a salvage pathway of nicotinamide adenine dinucleotide (NAD) biosynthesis. By virtue of this role, it can regulate cellular levels of NAD and so impact not only cellular energetics but also NAD-dependent enzymes such as sirtuins. Although it lacks a signal peptide, PBEF is released by a variety of cells, and elevated levels can be found in the systemic circulation of patients with a variety of inflammatory diseases. As an extracellular cytokine, PBEF can induce the cellular expression of inflammatory cytokines such as TNF-\u03b1, IL-1\u03b2, and IL-6. Finally, PBEF has been shown to be an adipokine expressed by fat cells that exerts a number of insulin mimetic and antagonistic effects. PBEF expression is up-regulated in a variety of acute and chronic inflammatory diseases including sepsis, acute lung injury, rheumatoid arthritis, inflammatory bowel disease, and myocardial infarction and plays a key role in the persistence of inflammation through its capacity to inhibit neutrophil apoptosis. This review summarizes the admittedly incomplete body of emerging knowledge about a remarkable new mediator of innate immunity.<\/jats:p>","DOI":"10.1189\/jlb.0807581","type":"journal-article","created":{"date-parts":[[2008,2,5]],"date-time":"2008-02-05T21:35:34Z","timestamp":1202247334000},"page":"804-816","source":"Crossref","is-referenced-by-count":239,"title":["Pre-B cell colony-enhancing factor (PBEF)\/visfatin: a novel mediator of innate immunity"],"prefix":"10.1093","volume":"83","author":[{"given":"Tracy","family":"Luk","sequence":"first","affiliation":[{"name":"Departments of Surgery and Critical Care Medicine and the Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital, University of Toronto , Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeenat","family":"Malam","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Critical Care Medicine and the Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital, University of Toronto , Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C","family":"Marshall","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Critical Care Medicine and the Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital, University of Toronto , Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,2,5]]},"reference":[{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/nature03985","article-title":"A network-based analysis of systemic inflammation in humans","volume":"437","author":"Calvano","year":"2005","journal-title":"Nature"},{"key":"2023033005450723200_","first-page":"1431","article-title":"Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor","volume":"14","author":"Samal","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0014-5793(03)00476-9","article-title":"Growth phase-dependent changes in the subcellular localization of pre-B-cell colony-enhancing factor","volume":"544","author":"Kitani","year":"2003","journal-title":"FEBS Lett."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1128\/JB.183.4.1168-1174.2001","article-title":"Identification of a plasmid-encoded gene from Haemophilus ducreyi which confers NAD independence","volume":"183","author":"Martin","year":"2001","journal-title":"J. Bacteriol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1089\/104454999314746","article-title":"Increased gene expression of a cytokine-related molecule and profilin after activation of Suberites domuncula cells with zenogeneic sponge molecule(s)","volume":"18","author":"Muller","year":"1999","journal-title":"DNA Cell Biol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1006\/fsim.2000.0263","article-title":"Molecular cloning and expression analysis of the putative carp (Cyprinus carpio) pre-B cell enhancing factor","volume":"10","author":"Fujiki","year":"2000","journal-title":"Fish Shellfish Immunol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10528-005-1505-2","article-title":"Molecular cloning and characterization of canine pre-B-cell colony-enhancing factor","volume":"43","author":"McGlothlin","year":"2005","journal-title":"Biochem. Genet."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1677\/jme.0.0260107","article-title":"Genomic organization of the gene coding for human pre-B-cell colony enhancing factor and expression in human fetal membranes","volume":"26","author":"Ognjanovic","year":"2001","journal-title":"J. Mol. Endocrinol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1067\/mob.2002.126295","article-title":"Pre-B cell colony-enhancing factor, a novel cytokine of human fetal membranes","volume":"187","author":"Ognjanovic","year":"2002","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1172\/JCI19930","article-title":"Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis","volume":"113","author":"Jia","year":"2004","journal-title":"J. Clin. Invest."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1002\/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L","article-title":"Pre-B cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis","volume":"32","author":"Rongvaux","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1126\/science.1097243","article-title":"Visfatin: a protein secreted by visceral fat that mimics the effects of insulin","volume":"307","author":"Fukuhara","year":"2005","journal-title":"Science"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1002\/art.21942","article-title":"Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis","volume":"54","author":"Nowell","year":"2006","journal-title":"Arthritis Rheum."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1210\/jc.2005-1475","article-title":"Elevated plasma level of visfatin\/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus","volume":"91","author":"Chen","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1164\/rccm.200404-563OC","article-title":"Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury","volume":"171","author":"Ye","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0014-5793(99)01578-1","article-title":"A profile of differentially expressed genes in primary colorectal cancer using suppressive subtractive hybridization","volume":"463","author":"Hufton","year":"1999","journal-title":"FEBS Lett."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1016\/j.febslet.2006.06.052","article-title":"Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1","volume":"580","author":"Bae","year":"2006","journal-title":"FEBS Lett."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nsmb1114","article-title":"Structure of Nampt\/PBEF\/visfatin, a mammalian NAD+ biosynthetic enzyme","volume":"13","author":"Wang","year":"2006","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/bioinformatics\/btg430","article-title":"The Jalview Java alignment editor","volume":"20","author":"Clamp","year":"2004","journal-title":"Bioinformatics"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"L1113","DOI":"10.1152\/ajplung.00266.2006","article-title":"Genomic insights into acute inflammatory lung injury","volume":"291","author":"Garcia","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-\u03baB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1038\/sj.onc.1204386","article-title":"Partners in transcription: NFAT and AP-1","volume":"20","author":"Maci\u00e1n","year":"2001","journal-title":"Oncogene"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1096\/fj.02-1148com","article-title":"Mechanical stretch activates nuclear factor-\u03baB, activator protein-1, and mitogen-activated protein kinases in lung parenchyma: implications in asthma","volume":"17","author":"Kumar","year":"2003","journal-title":"FASEB J."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jcp.20840","article-title":"Stretch-activated signaling pathways responsible for early response gene expression in fetal lung epithelial cells","volume":"210","author":"Copland","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1034\/j.1600-065X.2002.19002.x","article-title":"Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human disease","volume":"190","author":"Lazarus","year":"2002","journal-title":"Immunol. Rev."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1097\/01.CCM.0000260243.22758.4F","article-title":"Pre-B-cell colony-enhancing factor gene polymorphisms and risk of acute respiratory distress syndrome","volume":"35","author":"Bajwa","year":"2007","journal-title":"Crit. Care Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1038\/oby.2006.247","article-title":"A visfatin promoter polymorphism is associated with low-grade inflammation and type 2 diabetes","volume":"14","author":"Zhang","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.metabol.2007.01.009","article-title":"Effects of genetic variation in the visfatin gene (PBEF1) on obesity, glucose metabolism, and blood pressure in children","volume":"56","author":"K\u00f6rner","year":"2007","journal-title":"Metabolism"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.bbrc.2007.05.096","article-title":"Visfatin is released from 3T3\u2013L1 adipocytes via a non-classical pathway","volume":"359","author":"Tanaka","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jmb.2006.06.082","article-title":"Crystal structure of visfatin\/pre-B cell colony-enhancing factor 1\/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866","volume":"362","author":"Kim","year":"2006","journal-title":"J. Mol. Biol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/nar\/gkg086","article-title":"MMDB: Entrez\u2019s 3D-structure database","volume":"31","author":"Chen","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0968-0004(00)01561-9","article-title":"Cn3D: sequence and structure views for Entrez","volume":"25","author":"Wang","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1046\/j.1432-1327.2000.01187.x","article-title":"New functions of a long-known molecule. Emerging roles of NAD in cellular signaling","volume":"267","author":"Ziegler","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/MOG.0b013e32801b3c8f","article-title":"The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt\/PBEF\/visfatin in mammals","volume":"23","author":"Revollo","year":"2007","journal-title":"Curr. Opin. Gastroenterol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00018-003-3161-1","article-title":"Enzymology of NAD+ homeostasis in man","volume":"61","author":"Magni","year":"2004","journal-title":"Cell. Mol. Life Sci."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0021-9258(18)96977-2","article-title":"Nicotinamide mononucleotide pyrophosphorylase activity in animal tissues","volume":"241","author":"Dietrich","year":"1966","journal-title":"J. Biol. Chem."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1021\/bi00833a014","article-title":"Studies on the mechanism of rat liver nicotinamide mononucleotide pyrophosphorylase","volume":"8","author":"Powanda","year":"1969","journal-title":"Biochemistry"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"24574","DOI":"10.1074\/jbc.M610357200","article-title":"Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells","volume":"282","author":"Hara","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"36334","DOI":"10.1074\/jbc.M508660200","article-title":"Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms","volume":"280","author":"Berger","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1128\/MMBR.00040-05","article-title":"Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?","volume":"70","author":"Hassa","year":"2006","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1006\/bbrc.2001.5735","article-title":"Structural and functional characterization of human NAD kinase","volume":"288","author":"Lerner","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1189\/jlb.0804442","article-title":"Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation","volume":"78","author":"Sheppard","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood.V92.9.3007","article-title":"Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing","volume":"92","author":"Hampton","year":"1998","journal-title":"Blood"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2007.03.016","article-title":"Hydrogen peroxide sensing and signaling","volume":"26","author":"Veal","year":"2007","journal-title":"Mol. Cell"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tibs.2006.11.006","article-title":"NAD+ metabolism in health and disease","volume":"32","author":"Belenky","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20070140","article-title":"Sirtuins in mammals: insights into their biological function","volume":"404","author":"Michan","year":"2007","journal-title":"Biochem. J."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nature02789","article-title":"Sirtuin activators mimic caloric restriction and delay ageing in metazoans","volume":"430","author":"Wood","year":"2004","journal-title":"Nature"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.biochem.73.011303.073651","article-title":"The Sir2 family of protein deacetylases","volume":"73","author":"Blander","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1111\/j.1742-4658.2005.04862.x","article-title":"Small molecule regulation of Sir2 protein deacetylases","volume":"272","author":"Grubisha","year":"2005","journal-title":"FEBS J."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cbpa.2005.08.010","article-title":"The Sir 2 family of protein deacetylases","volume":"9","author":"Denu","year":"2005","journal-title":"Curr. Opin. Chem. Biol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.molcel.2005.02.022","article-title":"Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme","volume":"17","author":"Avalos","year":"2005","journal-title":"Mol. Cell"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1074\/jbc.M609554200","article-title":"Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1","volume":"282","author":"Tanno","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-\u03baB-dependent transcription and cell survival by the SIRT1 deacetylase","volume":"23","author":"Yeung","year":"2004","journal-title":"EMBO J."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"40364","DOI":"10.1074\/jbc.M509329200","article-title":"SIRT1 protects against microglia-dependent amyloid-\u03b2 toxicity through inhibiting NF-\u03baB signaling","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.intimp.2004.10.006","article-title":"Effect of cis-resveratrol on genes involved in nuclear factor \u03ba B signaling","volume":"5","author":"Leiro","year":"2005","journal-title":"Int. Immunopharmacol."},{"key":"2023033005450723200_","first-page":"2473","article-title":"The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity","volume":"116","author":"Nakae","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"20589","DOI":"10.1074\/jbc.M412357200","article-title":"Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes","volume":"280","author":"Frescas","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.tem.2006.04.002","article-title":"SIRT1 and endocrine signaling","volume":"17","author":"Yang","year":"2006","journal-title":"Trends Endocrinol. Metab."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nm0106-34","article-title":"Sirt1: a metabolic master switch that modulates lifespan","volume":"12","author":"Leibiger","year":"2006","journal-title":"Nat. Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.exger.2006.06.003","article-title":"Nampt\/PBEF\/visfatin: a regulator of mammalian health and longevity?","volume":"41","author":"Yang","year":"2006","journal-title":"Exp. Gerontol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1161\/01.RES.0000173298.38808.27","article-title":"Pre-B-cell colony-enhancing factor regulates NAD+-dependent protein deacetylase activity and promotes vascular smooth muscle cell maturation","volume":"97","author":"van der Veer","year":"2005","journal-title":"Circ. Res."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"10841","DOI":"10.1074\/jbc.C700018200","article-title":"Extension of human cell lifespan by nicotinamide phosphoribosyltransferase","volume":"282","author":"van der Veer","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1111\/j.1742-4658.2005.04876.x","article-title":"Physiological relevance of the endogenous mono(ADP-ribosyl)ation of cellular proteins","volume":"272","author":"di Girolamo","year":"2005","journal-title":"FEBS J."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"8231","DOI":"10.1073\/pnas.122238899","article-title":"ADP ribosylation of human neutrophil peptide-1 regulates its biological properties","volume":"99","author":"Paone","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1006\/bbrc.1999.0897","article-title":"Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity","volume":"260","author":"Frye","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"Wang","year":"1999","journal-title":"Science"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1594","article-title":"High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal","volume":"5","author":"Lotze","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1016\/S0021-9258(18)32583-3","article-title":"ADP-ribosylation of nonhistone high mobility group proteins in intact cells","volume":"258","author":"Tanuma","year":"1983","journal-title":"J. Biol. Chem."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1111\/j.1742-4658.2005.04864.x","article-title":"Poly(ADP-ribose). The most elaborate metabolite of NAD+","volume":"272","author":"B\u00fcrkle","year":"2005","journal-title":"FEBS J."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1126\/science.1074592","article-title":"Cell biology. PARP-1\u2014a perpetrator of apoptotic cell death?","volume":"297","author":"Chiarugi","year":"2002","journal-title":"Science"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1963","article-title":"Poly(ADP-ribose): novel functions for an old molecule","volume":"7","author":"Schreiber","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"43121","DOI":"10.1074\/jbc.M506162200","article-title":"Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2\u03b1 deacetylase activity","volume":"280","author":"Pillai","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1101\/gad.1331805","article-title":"Poly(ADP-ribosyl)ation by PARP-1: \u2018PAR-laying\u2019 NAD+ into a nuclear signal","volume":"19","author":"Kim","year":"2005","journal-title":"Genes Dev."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0006-291X(03)01483-9","article-title":"NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes","volume":"308","author":"Ying","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.bbrc.2006.05.042","article-title":"Regulation of intracellular levels of NAD: a novel role for CD38","volume":"345","author":"Aksoy","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbrc.2006.05.100","article-title":"Decreased cADPR and increased NAD+ in the Cd38\u2013\/\u2013 mouse","volume":"346","author":"Young","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/nm1101-1209","article-title":"Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo","volume":"7","author":"Partida-S\u00e1nchez","year":"2001","journal-title":"Nat. Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2119\/2006-00099.Lund","article-title":"Signaling properties of CD38 in the mouse immune system: enzyme-dependent and -independent roles in immunity","volume":"12","author":"Lund","year":"2006","journal-title":"Mol. Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"324","DOI":"10.2119\/2006-00075.Billington","article-title":"Emerging functions of extracellular pyridine nucleotides","volume":"12","author":"Billington","year":"2006","journal-title":"Mol. Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1096\/fj.00-0566fje","article-title":"Connexin 43 hemi channels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells","volume":"15","author":"Bruzzone","year":"2001","journal-title":"FASEB J."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S1074-7613(03)00266-8","article-title":"NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor","volume":"19","author":"Seman","year":"2003","journal-title":"Immunity"},{"key":"2023033005450723200_","first-page":"31419","article-title":"Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes","volume":"281","author":"Moreschi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1042\/BJ20051302","article-title":"Extracellular NAD+ regulates intracellular calcium levels and induces activation of human granulocytes","volume":"393","author":"Bruzzone","year":"2006","journal-title":"Biochem. J."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1124\/jpet.103.056556","article-title":"NAD+ ameliorates inflammation-induced epithelial barrier dysfunction in cultured enterocytes and mouse ileal mucosa","volume":"307","author":"Han","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"L1082","DOI":"10.1152\/ajplung.00358.2001","article-title":"Liposomal NAD(+) prevents diminished O(2) consumption by immunostimulated Caco-2 cells","volume":"282","author":"Khan","year":"2002","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1189\/jlb.72.2.410","article-title":"Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1","volume":"72","author":"Xu","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0161-5890(01)00097-9","article-title":"Genes expressed during the IFN \u03b3-induced maturation of pre-B cells","volume":"38","author":"Patrone","year":"2002","journal-title":"Mol. Immunol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.mvr.2005.08.003","article-title":"Pre-Bcell-colony-enhancing factor is critically involved in thrombin-induced lung endothelial cell barrier dysregulation","volume":"70","author":"Ye","year":"2005","journal-title":"Microvasc. Res."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1161\/CIRCULATIONAHA.106.665893","article-title":"Increased expression of visfatin in macrophages of human unstable carotid and coronary atherosclerosis: possible role in inflammation and plaque destabilization","volume":"115","author":"Dahl","year":"2007","journal-title":"Circulation"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.bbrc.2006.02.109","article-title":"TNF regulates cellular NAD+ metabolism in primary macrophages","volume":"342","author":"Iqbal","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0002-9378(00)70491-1","article-title":"Fetal membrane distention I. Differentially expressed genes regulated by acute distention in amniotic epithelial (WISH) cells","volume":"182","author":"Nemeth","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"E586","DOI":"10.1152\/ajpendo.00090.2005","article-title":"Interleukin-6 is a negative regulator of visfatin gene expression in 3T3\u2013L1 adipocytes","volume":"289","author":"Kralisch","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1677\/joe.1.06211","article-title":"Hormonal regulation of the novel adipocytokine visfatin in 3T3\u2013L1 adipocytes","volume":"185","author":"Kralisch","year":"2005","journal-title":"J. Endocrinol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1463-1326.2006.00625.x","article-title":"Visfatin expression is hormonally regulated by metabolic and sex hormones in 3T3\u2013L1 preadipocytes and adipocytes","volume":"9","author":"MacLaren","year":"2007","journal-title":"Diabetes Obes. Metab."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1055\/s-2007-973075","article-title":"TNF-\u03b1 alters visfatin and adiponectin levels in human fat","volume":"39","author":"Hector","year":"2007","journal-title":"Horm. Metab. Res."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0002-9378(93)90096-2","article-title":"Tumor necrosis factor, interleukin-1, and interleukin-6 in normal human pregnancy","volume":"169","author":"Opsjln","year":"1993","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2023033005450723200_","first-page":"1201","article-title":"Interleukin-8 induces proliferation of endometrial stromal cells: a potential autocrine growth factor","volume":"83","author":"Arici","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.4049\/jimmunol.178.3.1748","article-title":"Visfatin, an adipocytokine with proinflammatory and immunomodulating properties","volume":"178","author":"Moschen","year":"2007","journal-title":"J. Immunol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1126\/science.318.5850.565b","article-title":"Retraction","volume":"318","author":"Fukuhara","year":"2007","journal-title":"Science"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jaci.2005.02.023","article-title":"Adipose tissue, adipokines, and inflammation","volume":"115","author":"Fantuzzi","year":"2005","journal-title":"J. Allergy Clin. Immunol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nri1937","article-title":"Adipocytokines: mediators linking adipose tissue, inflammation and immunity","volume":"6","author":"Tilg","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1016\/j.febslet.2006.04.028","article-title":"The metabolic syndrome and adipocytokines","volume":"580","author":"Matsuzawa","year":"2006","journal-title":"FEBS Lett."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1365-2362.2007.01755.x","article-title":"The metabolic syndrome: metabolic changes with vascular consequences","volume":"37","author":"Wassink","year":"2007","journal-title":"Eur. J. Clin. Invest."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1007\/s00018-007-6359-9","article-title":"Regulation of insulin receptor function","volume":"64","author":"Youngren","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1089\/ars.2005.7.1040","article-title":"The molecular basis for oxidative stress-induced insulin resistance","volume":"7","author":"Evans","year":"2005","journal-title":"Antioxid. Redox Signal."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1172\/JCI29069","article-title":"Inflammation and insulin resistance","volume":"116","author":"Shoelson","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1172\/JCI113711","article-title":"The insulin receptor and the molecular mechanism of insulin action","volume":"82","author":"Kahn","year":"1988","journal-title":"J. Clin. Invest."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2119\/2005-00029.Saltiel","article-title":"Insulin signaling and the regulation of glucose transport","volume":"10","author":"Chang","year":"2004","journal-title":"Mol. Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1023\/A:1006823109415","article-title":"Insulin signal transduction through protein kinase cascades","volume":"182","author":"Avruch","year":"1998","journal-title":"Mol. Cell. Biochem."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrm1837","article-title":"Critical nodes in signaling pathways: insights into insulin action","volume":"7","author":"Taniguchi","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1007\/s00125-006-0303-7","article-title":"The release of the adipocytokine visfatin is regulated by glucose and insulin","volume":"49","author":"Haider","year":"2006","journal-title":"Diabetologia"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1210\/jc.2006-1013","article-title":"Exercise training lowers plasma visfatin concentrations in patients with type 1 diabetes","volume":"91","author":"Haider","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.diabres.2006.07.031","article-title":"Plasma visfatin levels in patients with newly diagnosed and untreated type 2 diabetes mellitus and impaired glucose tolerance","volume":"76","author":"Dogru","year":"2007","journal-title":"Diabetes Res. Clin. Pract."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.2337\/db06-0259","article-title":"Serum visfatin increases with progressive \u03b2-cell deterioration","volume":"55","author":"L\u00f3pez-Bermejo","year":"2006","journal-title":"Diabetes"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1042\/CS20050363","article-title":"Increased visfatin concentrations in women with gestational diabetes mellitus","volume":"110","author":"Krzyzanowska","year":"2006","journal-title":"Clin. Sci. (Lond.)"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00125-007-0610-7","article-title":"Elevated serum levels of visfatin in gestational diabetes: a comparative study across various degrees of glucose tolerance","volume":"50","author":"Lewandowski","year":"2007","journal-title":"Diabetologia"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/j.1464-5491.2006.01909.x","article-title":"The visfatin gene is associated with glucose and lipid metabolism in a Chinese population","volume":"23","author":"Jian","year":"2006","journal-title":"Diabet. Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jsgi.2006.04.007","article-title":"Decreased plasma visfatin concentrations in women with gestational diabetes mellitus","volume":"13","author":"Chan","year":"2006","journal-title":"J. Soc. Gynecol. Investig."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.2337\/diabetes.54.10.2911","article-title":"Plasma visfatin concentrations and fat depot-specific mRNA expression in humans","volume":"54","author":"Berndt","year":"2005","journal-title":"Diabetes"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"4738","DOI":"10.1210\/jc.2007-1304","article-title":"Molecular characteristics of serum visfatin and differential detection by immunoassays","volume":"92","author":"K\u00f6rner","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00223-006-0155-7","article-title":"Insulin-like effects of visfatin on human osteoblasts","volume":"80","author":"Xie","year":"2007","journal-title":"Calcif. Tissue Int."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cmet.2007.09.003","article-title":"Nampt\/PBEF\/visfatin regulates insulin secretion in \u03b2 cells as a systemic NAD biosynthetic enzyme","volume":"6","author":"Revollo","year":"2007","journal-title":"Cell Metab."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit. Care Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000","volume":"348","author":"Martin","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1097\/01.CCM.0000261890.41311.E9","article-title":"Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003","volume":"35","author":"Dombrovskiy","year":"2007","journal-title":"Crit. Care Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1001\/archinte.167.15.1655","article-title":"Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study","volume":"167","author":"Kellum","year":"2007","journal-title":"Arch. Intern. Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","article-title":"The pathophysiology and treatment of sepsis","volume":"348","author":"Hotchkiss","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/jlb.56.6.672","article-title":"Neutrophils, host defense, and inflammation: a double-edged sword","volume":"56","author":"Smith","year":"1994","journal-title":"J. Leukoc. Biol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0140-6736(06)69005-3","article-title":"Neutrophils in development of multiple organ failure in sepsis","volume":"368","author":"Brown","year":"2006","journal-title":"Lancet"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1172\/JCI113970","article-title":"Macrophage phagocytosis of aging neutrophils in inflammation","volume":"83","author":"Savill","year":"1989","journal-title":"J. Clin. Invest."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1001\/archsurg.1997.01430360009002","article-title":"Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome (SIRS)","volume":"132","author":"Jimenez","year":"1997","journal-title":"Arch. Surg."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1097\/01.CCM.0000129975.26905.77","article-title":"Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential (\u0394\u03c8M) and reduced caspase-9 activity","volume":"32","author":"Taneja","year":"2004","journal-title":"Crit. Care Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"III20","DOI":"10.1161\/01.CIR.0000131514.71167.2e","article-title":"Inflammation in atherosclerosis and implications for therapy","volume":"109","author":"Paoletti","year":"2004","journal-title":"Circulation"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1136\/ard.2005.046540","article-title":"Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis","volume":"65","author":"Otero","year":"2006","journal-title":"Ann. Rheum. Dis."},{"key":"2023033005450723200_","first-page":"251","article-title":"Gene expression profiling of peripheral blood mononuclear leukocytes from psoriasis patients identifies new immune regulatory molecules","volume":"15","author":"Koczan","year":"2005","journal-title":"Eur. J. Dermatol."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.amjmed.2006.11.012","article-title":"Abdominal obesity: role in the pathophysiology of metabolic disease and cardiovascular risk","volume":"120","author":"Bergman","year":"2007","journal-title":"Am. J. Med."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.metabol.2007.04.007","article-title":"Serum concentration of visfatin in obese women","volume":"56","author":"Zahorska-Markiewicz","year":"2007","journal-title":"Metabolism"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF03346300","article-title":"Increased plasma levels of visfatin\/pre-B cell colony-enhancing factor in obese and overweight patients with metabolic syndrome","volume":"30","author":"Filippatos","year":"2007","journal-title":"J. Endocrinol. Invest."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.metabol.2006.12.005","article-title":"Serum visfatin in relation to visceral fat, obesity, and type 2 diabetes mellitus in Asian Indians","volume":"56","author":"Sandeep","year":"2007","journal-title":"Metabolism"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.metabol.2007.04.018","article-title":"The relationship between visfatin levels and anthropometric and metabolic parameters: association with cholesterol levels in women","volume":"56","author":"Chen","year":"2007","journal-title":"Metabolism"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1210\/jc.2006-0361","article-title":"Reduced plasma visfatin\/pre-B cell colony-enhancing factor in obesity is not related to insulin resistance in humans","volume":"91","author":"Pagano","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1038\/oby.2006.219","article-title":"Increase in visfatin after weight loss induced by gastroplastic surgery","volume":"14","author":"Krzyzanowska","year":"2006","journal-title":"Obesity (Silver Spring)"},{"key":"2023033005450723200_","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1210\/jc.2006-0960","article-title":"Effect of massive weight loss on inflammatory adipocytokines and the innate immune system in morbidly obese women","volume":"92","author":"Manco","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/83\/4\/804\/49635319\/jlb0804.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/83\/4\/804\/49635319\/jlb0804.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T03:53:42Z","timestamp":1684209222000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/83\/4\/804\/6975443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,5]]},"references-count":143,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2008,2,5]]},"published-print":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1189\/jlb.0807581","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,4]]},"published":{"date-parts":[[2008,2,5]]}}}