{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:06:17Z","timestamp":1790550377686,"version":"4.1.0"},"reference-count":112,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Since the establishment of cell lines derived from human embryonic stem (ES) cells, it has been speculated that out of such \u201craw material,\u201d we could some day produce all sorts of replacement parts for the human body. Human pluripotent stem cells can be isolated from embryonic, fetal, or adult tissues. Enormous self-renewal capacity and developmental potential are the characteristics of ES cells. Somatic stem cells, especially those derived from hematopoietic tissues, have also been reported to exhibit developmental potential heretofore not considered possible. The initial evidences for the plasticity potential of somatic stem cells were so encouraging that the opponents of ES cell research used them as arguments for restricting ES cell research. In the past months, however, critical issues have been raised challenging the validity and the interpretation of the initial data. Whereas hematopoietic stem-cell therapy has been a clinical reality for almost 40 years, there is still a long way to go in basic research before novel therapy strategies with stem cells as replacement for other organ systems can be established. Given the present status, we should keep all options open for research in ES cells and adult stem cells to appreciate the complexity of their differentiation pathways and the relative merits of various types of stem cells for regenerative medicine.<\/jats:p>","DOI":"10.1189\/jlb.0902458","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T19:20:31Z","timestamp":1051212031000},"page":"547-555","source":"Crossref","is-referenced-by-count":21,"title":["Hematopoietic stem cells: can old cells learn new tricks?"],"prefix":"10.1093","volume":"73","author":[{"given":"Anthony D","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Medicine V, University of Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Punzel","sequence":"additional","affiliation":[{"name":"Department of Medicine V, University of Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,5,1]]},"reference":[{"key":"2023033018592775800_jlb0547-cit-B1","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1126\/science.287.5457.1442","article-title":"Translating stem and progenitor cell biology to the clinic: barriers and opportunities","volume":"287","author":"Weissman","year":"2000","journal-title":"Science"},{"key":"2023033018592775800_jlb0547-cit-B2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/jcp.1030620313","article-title":"The distribution of colony-forming cells among spleen colonies","volume":"62","author":"Siminovitch","year":"1963","journal-title":"J. Cell. Comp. Physiol."},{"key":"2023033018592775800_jlb0547-cit-B3","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/197452a0","article-title":"Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells","volume":"197","author":"Becker","year":"1963","journal-title":"Nature"},{"key":"2023033018592775800_jlb0547-cit-B4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0092-8674(00)81691-8","article-title":"Stem cells: a new lease on life","volume":"100","author":"Fuchs","year":"2000","journal-title":"Cell"},{"key":"2023033018592775800_jlb0547-cit-B5","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/385810a0","article-title":"Viable offspring derived from fetal and adult mammalian cells","volume":"385","author":"Wilmut","year":"1997","journal-title":"Nature"},{"key":"2023033018592775800_jlb0547-cit-B6","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.282.5391.1145","article-title":"Embryonic stem cell lines derived from human blastocysts","volume":"282","author":"Thomson","year":"1998","journal-title":"Science"},{"key":"2023033018592775800_jlb0547-cit-B7","doi-asserted-by":"crossref","first-page":"13726","DOI":"10.1073\/pnas.95.23.13726","article-title":"Derivation of pluripotent stem cells from cultured human primordial germ cells","volume":"95","author":"Shamblott","year":"1998","journal-title":"Proc. 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Cell Biol."},{"key":"2023033018592775800_jlb0547-cit-B10","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/S0140-6736(68)92672-X","article-title":"Bone-marrow transplantation in a patient with the Wiskott-Aldrich syndrome","volume":"2","author":"Bach","year":"1968","journal-title":"Lancet"},{"key":"2023033018592775800_jlb0547-cit-B11","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/S0140-6736(68)92673-1","article-title":"Immunological reconstitution of sex-linked lymphopenic immunological deficiency","volume":"2","author":"Gatti","year":"1968","journal-title":"Lancet"},{"key":"2023033018592775800_jlb0547-cit-B12","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(69)92112-6","article-title":"Transplantation of bone-marrow cells and fetal thymus in an infant with lymphopenic immunological deficiency","volume":"1","author":"de Koning","year":"1969","journal-title":"Lancet"},{"key":"2023033018592775800_jlb0547-cit-B13","first-page":"248","article-title":"Allogeneic marrow grafting using HL-A matched donor-recipinet sibling pairs","volume":"84","author":"Thomas","year":"1971","journal-title":"Trans. Assoc. Am. Physicians"},{"key":"2023033018592775800_jlb0547-cit-B14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1182\/blood.V67.2.529.529","article-title":"Autologous transplantation of blood-derived hemopoietic stem cells after myeloablative therapy in a patient with Burkitt\u2019s lymphoma","volume":"67","author":"K\u00f6rbling","year":"1986","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B15","first-page":"94","article-title":"Successful autologous transplantation of blood stem cells mobilized with recombinant human granulocyte-macrophage colony-stimulating factor","volume":"18","author":"Haas","year":"1990","journal-title":"Exp. Hematol."},{"key":"2023033018592775800_jlb0547-cit-B16","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1182\/blood.V85.1.275.bloodjournal851275","article-title":"Harvesting and enrichment of hematopoietic progenitor cells mobilized into the peripheral blood of normal donors by granulocyte macrophage-colony stimulating factor (GM-CSF) or G-CSF: potential role in allogeneic marrow transplantation","volume":"85","author":"Lane","year":"1995","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B17","first-page":"40","article-title":"Early lymphoematopoietic recovery after autografting using peripheral blood SEM cells in acue non-lympolastic leukemia","volume":"20","author":"Juttner","year":"1988","journal-title":"Transplant. Proc."},{"key":"2023033018592775800_jlb0547-cit-B18","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1182\/blood.V86.5.2052a.bloodjournal8652052a","article-title":"Rapid and sustained allogeneic transplantation using immunoselected CD34+-selected peripheral blood progenitor cells mobilized by recombinant granulocyte- and granulocyte-macrophage colony-stimulating factors","volume":"86","author":"Corringham","year":"1995","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B19","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1073\/pnas.98.1.113","article-title":"Human embryonic germ cell derivatives express a broad range of developmentally distinct markers and proliferate extensively in vitro","volume":"98","author":"Shamblott","year":"2001","journal-title":"Proc. Natl. Acad. Sci. 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Invest."},{"key":"2023033018592775800_jlb0547-cit-B23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.49.2.157","article-title":"Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice","volume":"49","author":"Soria","year":"2000","journal-title":"Diabetes"},{"key":"2023033018592775800_jlb0547-cit-B24","doi-asserted-by":"crossref","first-page":"10716","DOI":"10.1073\/pnas.191362598","article-title":"Hematopoietic colony-forming cells derived from human embryonic stem cells","volume":"98","author":"Kaufman","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033018592775800_jlb0547-cit-B25","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.279.5356.1528","article-title":"Muscle regeneration by bone marrow-derived myogenic progenitors","volume":"279","author":"Ferrari","year":"1998","journal-title":"Science"},{"key":"2023033018592775800_jlb0547-cit-B26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s004290050036","article-title":"Dystrophin expression in heterozygous mdx\/+ mice indicates imprinting of X chromosome inactivation by parent-of-origin-, tissue-, strain- and position-dependent factors","volume":"195","author":"Bittner","year":"1997","journal-title":"Anat. Embryol. (Berl.)"},{"key":"2023033018592775800_jlb0547-cit-B27","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/43919","article-title":"Dystrophin expression in the mdx mouse restored by stem cell transplantation","volume":"401","author":"Gussoni","year":"1999","journal-title":"Nature"},{"key":"2023033018592775800_jlb0547-cit-B28","doi-asserted-by":"crossref","first-page":"14482","DOI":"10.1073\/pnas.96.25.14482","article-title":"Hematopoietic potential of stem cells isolated from murine skeletal muscle","volume":"96","author":"Jackson","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033018592775800_jlb0547-cit-B29","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1172\/JCI12150","article-title":"Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells","volume":"107","author":"Jackson","year":"2001","journal-title":"J. Clin. 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Bone Miner. Res."},{"key":"2023033018592775800_jlb0547-cit-B37","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/S0301-472X(99)00122-8","article-title":"Vascular smooth muscle differentiation of murine stroma: a sequential model","volume":"27","author":"Remy-Martin","year":"1999","journal-title":"Exp. Hematol."},{"key":"2023033018592775800_jlb0547-cit-B38","doi-asserted-by":"crossref","first-page":"S247","DOI":"10.1097\/00003086-199810001-00025","article-title":"Mesenchymal stem cells in osteobiology and applied bone regeneration","volume":"355","author":"Bruder","year":"1998","journal-title":"Clin. Orthop."},{"key":"2023033018592775800_jlb0547-cit-B39","first-page":"2078","article-title":"Generation of cardiomyocytes from mesenchymal stem cells","volume":"45","author":"Fukuda","year":"2000","journal-title":"Tanpakushitsu Kakusan Koso"},{"key":"2023033018592775800_jlb0547-cit-B40","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1073\/pnas.92.11.4857","article-title":"Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice","volume":"92","author":"Pereira","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033018592775800_jlb0547-cit-B41","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/81326","article-title":"Purified hematopoietic stem cells can differentiate into hepatocytes in vivo","volume":"6","author":"Lagasse","year":"2000","journal-title":"Nat. Med."},{"key":"2023033018592775800_jlb0547-cit-B42","first-page":"571","article-title":"Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells","volume":"158","author":"Wang","year":"2001","journal-title":"Am. J. Physiol."},{"key":"2023033018592775800_jlb0547-cit-B43","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0092-8674(01)00328-2","article-title":"Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell","volume":"105","author":"Krause","year":"2001","journal-title":"Cell"},{"key":"2023033018592775800_jlb0547-cit-B44","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1126\/science.1074807","article-title":"Little evidence for developmental plasticity of adult hematopoietic stem cells","volume":"297","author":"Wagers","year":"2002","journal-title":"Science"},{"key":"2023033018592775800_jlb0547-cit-B45","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"2023033018592775800_jlb0547-cit-B46","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1089\/ten.1998.4.415","article-title":"Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow","volume":"4","author":"Mackay","year":"1998","journal-title":"Tissue Eng."},{"key":"2023033018592775800_jlb0547-cit-B47","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/(SICI)1097-4644(199702)64:2<295::AID-JCB12>3.0.CO;2-I","article-title":"Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro","volume":"64","author":"Jaiswal","year":"1997","journal-title":"J. Cell. Biochem."},{"key":"2023033018592775800_jlb0547-cit-B48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/(SICI)1097-4652(199910)181:1<67::AID-JCP7>3.0.CO;2-C","article-title":"Phenotypical and functional properties of human bone marrow mesenchymal progenitor cells","volume":"181","author":"Conget","year":"1999","journal-title":"J. Cell. Physiol."},{"key":"2023033018592775800_jlb0547-cit-B49","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1172\/JCI10413","article-title":"Marrow stromal cells","volume":"105","author":"Bianco","year":"2000","journal-title":"J. Clin. Invest."},{"key":"2023033018592775800_jlb0547-cit-B50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/jhep.2000.9124","article-title":"Liver from bone marrow in humans","volume":"32","author":"Theise","year":"2000","journal-title":"Hepatology"},{"key":"2023033018592775800_jlb0547-cit-B51","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature00870","article-title":"Pluripotency of mesenchymal stem cells derived from adult marrow","volume":"418","author":"Jiang","year":"2002","journal-title":"Nature"},{"key":"2023033018592775800_jlb0547-cit-B52","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1172\/JCI0215182","article-title":"Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells","volume":"109","author":"Schwartz","year":"2002","journal-title":"J. Clin. Invest."},{"key":"2023033018592775800_jlb0547-cit-B53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/exnr.2001.7853","article-title":"Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats","volume":"174","author":"Zhao","year":"2002","journal-title":"Exp. Neurol."},{"key":"2023033018592775800_jlb0547-cit-B54","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1182\/blood.V98.9.2615","article-title":"Purification and ex vivo expansion of postnatal human marrow mesodermal progenitor cells","volume":"98","author":"Reyes","year":"2001","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B55","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1182\/blood.V96.2.763","article-title":"Microchimerism in bone marrow-derived CD34+ cells of patients after liver transplantation","volume":"96","author":"Nierhoff","year":"2000","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B56","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJMoa3461002","article-title":"Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells","volume":"346","author":"K\u00f6rbling","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"2023033018592775800_jlb0547-cit-B57","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/35070587","article-title":"Bone marrow cells regenerate infarcted myocardium","volume":"410","author":"Orlic","year":"2001","journal-title":"Nature"},{"key":"2023033018592775800_jlb0547-cit-B58","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/86498","article-title":"Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function","volume":"7","author":"Kocher","year":"2001","journal-title":"Nat. Med."},{"key":"2023033018592775800_jlb0547-cit-B59","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1126\/science.283.5401.534","article-title":"Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo","volume":"283","author":"Bjornson","year":"1999","journal-title":"Science"},{"key":"2023033018592775800_jlb0547-cit-B60","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1126\/science.288.5471.1660","article-title":"Generalized potential of adult neural stem cells","volume":"288","author":"Clarke","year":"2000","journal-title":"Science"},{"key":"2023033018592775800_jlb0547-cit-B61","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nm0302-268","article-title":"Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations","volume":"8","author":"Morshead","year":"2002","journal-title":"Nat. Med."},{"key":"2023033018592775800_jlb0547-cit-B62","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1126\/science.295.5562.1989","article-title":"Stem cell research. Studies cast doubt on plasticity of adult cells","volume":"295","author":"Vogel","year":"2002","journal-title":"Science"},{"key":"2023033018592775800_jlb0547-cit-B63","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nature729","article-title":"Changing potency by spontaneous fusion","volume":"416","author":"Ying","year":"2002","journal-title":"Nature"},{"key":"2023033018592775800_jlb0547-cit-B64","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature730","article-title":"Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion","volume":"416","author":"Terada","year":"2002","journal-title":"Nature"},{"key":"2023033018592775800_jlb0547-cit-B65","doi-asserted-by":"crossref","first-page":"10344","DOI":"10.1073\/pnas.181177898","article-title":"Mobilized bone marrow cells repair the infarcted heart, improving function and surviva","volume":"98","author":"Orlic","year":"2001","journal-title":"Proc. Natl. Acad. Sci. 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Leukoc. Biol."},{"key":"2023033018592775800_jlb0547-cit-B74","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1182\/blood.V94.1.106.413k01_106_113","article-title":"Ex vivo expansion of autologous bone marrow CD34+ cells with porcine microvascular endothelial cells results in a graft capable of rescuing lethally irradiated baboons","volume":"94","author":"Brandt","year":"1999","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B75","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0092-8674(92)90468-R","article-title":"Mechanisms of asymmetric cell division: two Bs or not two Bs, that is the question","volume":"68","author":"Horvitz","year":"1992","journal-title":"Cell"},{"key":"2023033018592775800_jlb0547-cit-B76","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0168-9525(96)10050-0","article-title":"Neuroblasts: a model for the asymmetric division of stem cells","volume":"13","author":"Lin","year":"1997","journal-title":"Trends Genet."},{"key":"2023033018592775800_jlb0547-cit-B77","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1182\/blood.V94.8.2595.420k37_2595_2604","article-title":"Symmetry of initial cell divisions among primitive hematopoietic progenitors is independent of ontogenic age and regulatory molecules","volume":"94","author":"Huang","year":"1999","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B78","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0301-472X(02)00781-6","article-title":"Functional analysis of initial cell divisions defines the subsequent fate of individual human CD34+\/CD38\u2013 cells","volume":"30","author":"Punzel","year":"2002","journal-title":"Exp. Hematol."},{"key":"2023033018592775800_jlb0547-cit-B79","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1182\/blood.V93.11.3750","article-title":"The myeloid-lymphoid initiating cell (ML-IC) assay assesses the fate of multipotent human progenitors in vitro","volume":"93","author":"Punzel","year":"1999","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B80","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1182\/blood.V92.2.345b","article-title":"Lineage commitment and maturation in hematopoietic cells: the case for extrinsic regulation","volume":"92","author":"Metcalf","year":"1998","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B81","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1182\/blood.V92.2.348","article-title":"Do stem cells play dice","volume":"92","author":"Enver","year":"1998","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B82","doi-asserted-by":"crossref","DOI":"10.1016\/S0301-472X(03)00024-9","article-title":"The symmetry of initial divisions of human hematopoietic progenitors is altered only by the cellular microenvironment","author":"Punzel","year":"2003"},{"key":"2023033018592775800_jlb0547-cit-B83","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1182\/blood.V66.2.327.327","article-title":"Disparate differentiation in hemopoietic colonies derived from human paired progenitors","volume":"66","author":"Leary","year":"1985","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B84","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1084\/jem.188.6.1117","article-title":"Asymmetric cell divisions sustain long-term hematopoiesis from single-sorted human fetal liver cells","volume":"188","author":"Brummendorf","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023033018592775800_jlb0547-cit-B85","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/jcp.1041570318","article-title":"Lineage commitment in human hemopoiesis involves asymmetric cell division of multipotent progenitors and does not appear to be influenced by cytokines","volume":"157","author":"Mayani","year":"1993","journal-title":"J. Cell. Physiol."},{"key":"2023033018592775800_jlb0547-cit-B86","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/33854","article-title":"Asymmetric cell division","volume":"392","author":"Yuh","year":"1998","journal-title":"Nature"},{"key":"2023033018592775800_jlb0547-cit-B87","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0896-6273(00)80278-0","article-title":"Control of daughter cell fates during asymmetric divison: interaction of numb and notch","volume":"17","author":"Guo","year":"1996","journal-title":"Neuron"},{"key":"2023033018592775800_jlb0547-cit-B88","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0092-8674(95)90035-7","article-title":"Cleavage orientation and the asymmetric inheritance of Notch1 immunoreactivity in mammalian neurogenesis","volume":"82","author":"Chenn","year":"1995","journal-title":"Cell"},{"key":"2023033018592775800_jlb0547-cit-B89","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1242\/dev.121.10.3187","article-title":"The prospero transcription factor is asymmetrically localized to the cell cortex during neuroblast mitosis in Drosophila","volume":"121","author":"Spana","year":"1995","journal-title":"Development"},{"key":"2023033018592775800_jlb0547-cit-B90","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0092-8674(00)80505-X","article-title":"Miranda is required for the asymmetric localization of propero during mitosis in Drosophila","volume":"90","author":"Chun-Pyn","year":"1997","journal-title":"Cell"},{"key":"2023033018592775800_jlb0547-cit-B91","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1126\/science.1066707","article-title":"Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue","volume":"294","author":"Kiger","year":"2001","journal-title":"Science"},{"key":"2023033018592775800_jlb0547-cit-B92","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1126\/science.1066700","article-title":"Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling","volume":"294","author":"Tulina","year":"2001","journal-title":"Science"},{"key":"2023033018592775800_jlb0547-cit-B93","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1093\/emboj\/18.15.4261","article-title":"STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells","volume":"18","author":"Matsuda","year":"1999","journal-title":"EMBO J."},{"key":"2023033018592775800_jlb0547-cit-B94","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1172\/JCI115701","article-title":"Engraftment and long-term expression of human fetal hematopoietic stem cells in sheep following transplantation in utero","volume":"89","author":"Zanjani","year":"1992","journal-title":"J. Clin. Invest."},{"key":"2023033018592775800_jlb0547-cit-B95","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0925-5710(96)00445-8","article-title":"The human\/sheep xenograft model: a large animal model of human hematopoiesis","volume":"63","author":"Zanjani","year":"1996","journal-title":"Int. J. Hematol."},{"key":"2023033018592775800_jlb0547-cit-B96","first-page":"24","article-title":"Retention of long-term repopulating ability of xenogeneic transplanted purified adult human bone marrow hematopoietic stem cells in sheep","volume":"126","author":"Zanjani","year":"1995","journal-title":"J. Lab. Clin. Med."},{"key":"2023033018592775800_jlb0547-cit-B97","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1182\/blood.V87.10.4136.bloodjournal87104136","article-title":"CD34-positive human marrow cells that express low levels of Kit protein are enriched for long-term marrow engrafting cells","volume":"87","author":"Kawashima","year":"1996","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B98","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1182\/blood.V88.11.4102.bloodjournal88114102","article-title":"Sustained, retransplantable, multilineage engraftment of highly purified adult human bone marrow stem cells in vivo","volume":"88","author":"Civin","year":"1996","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B99","first-page":"353","article-title":"Human bone marrow CD34\u2013 cells engraft in vivo and undergo multilineage expression including giving rise to CD34+ cells","volume":"26","author":"Zanjani","year":"1998","journal-title":"Exp. Hematol."},{"key":"2023033018592775800_jlb0547-cit-B100","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1126\/science.285.5433.1553","article-title":"KDR receptor: a key marker defining hematopoietic stem cells","volume":"285","author":"Ziegler","year":"1999","journal-title":"Science"},{"key":"2023033018592775800_jlb0547-cit-B101","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1182\/blood.V95.11.3620","article-title":"Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation","volume":"95","author":"Almeida-Porada","year":"2000","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B102","first-page":"482","article-title":"Detection of human cells in human\/sheep chimeric lambs with in vitro human stroma-forming potential","volume":"24","author":"Almeida-Porada","year":"1996","journal-title":"Exp. Hematol."},{"key":"2023033018592775800_jlb0547-cit-B103","first-page":"494","article-title":"Production of human hepatocytes by human CD34+\/\u2013 cells in vivo","volume":"96","author":"Zanjani","year":"2001","journal-title":"Blood"},{"key":"2023033018592775800_jlb0547-cit-B104","first-page":"1162","article-title":"Candidate hematopoietic stem cells from fetal tissues, umbilical cord blood vs. adult bone marrow and mobilized peripheral blood","volume":"26","author":"Huang","year":"1998","journal-title":"Exp. Hematol."},{"key":"2023033018592775800_jlb0547-cit-B105","doi-asserted-by":"crossref","first-page":"8424","DOI":"10.1073\/pnas.90.18.8424","article-title":"Derivation of completely cell culture-derived mice from early passage embryonic stem cells","volume":"90","author":"Nagy","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033018592775800_jlb0547-cit-B106","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/jcp.1136","article-title":"Enhanced proliferation and differentiation of rat hepatocytes cultured with bone marrow stromal cells","volume":"189","author":"Mizuguchi","year":"2001","journal-title":"J. Cell. Physiol."},{"key":"2023033018592775800_jlb0547-cit-B107","doi-asserted-by":"crossref","first-page":"6776","DOI":"10.1073\/pnas.94.13.6776","article-title":"In vivo repopulating hematopoietic stem cells are present in the murine yolk sac at day 9.0 postcoitus","volume":"94","author":"Yoder","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033018592775800_jlb0547-cit-B108","doi-asserted-by":"crossref","first-page":"10716","DOI":"10.1073\/pnas.191362598","article-title":"Hematopoietic colony-forming cells derived from human embryonic stem cells","volume":"98","author":"Kaufman","year":"2001","journal-title":"Proc. Natl. Acad. Sci. 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