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Many of the events in this process have yet to be molecularly characterized. To identify novel HEC-specific proteins with potential function in the recruitment cascade, we sequenced a normalized human tonsil HEC cDNA library (generated from an inflamed tonsil) from which lymphocyte and human umbilical vein endothelial cell cDNAs had een subtracted. One-thousand forty-nine sequences were analyzed. All but three mapped to known cDNAs or genomic DNAs. The two most abundant transcripts encoded \u03b12-macroglobulin and hevin. The next-abundant transcripts encoded several other protease inhibitors, making this protein class the most prominent in HEC. Several endothelial-specific transcripts were also identified, including those encoding E-selectin, vascular cell adhesion molecule-1, vascular endothelial-junctional adhesion molecule, and platelet-endothelial cell adhesion molecule-1. The library contains a great diversity of transcripts, and studies of the encoded proteins will provide further insight into the complex biology of these specialized endothelial cells.<\/jats:p>","DOI":"10.1189\/jlb.0903408","type":"journal-article","created":{"date-parts":[[2004,2,10]],"date-time":"2004-02-10T01:12:57Z","timestamp":1076375577000},"page":"910-927","source":"Crossref","is-referenced-by-count":15,"title":["Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking"],"prefix":"10.1093","volume":"75","author":[{"given":"Diana","family":"Palmeri","sequence":"first","affiliation":[{"name":"Department of Anatomy and Program of Immunology, University of California , San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Rong","family":"Zuo","sequence":"additional","affiliation":[{"name":"Inflammatory Diseases Unit, Roche Bioscience , Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Program of Immunology, University of California , San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Hemmerich","sequence":"additional","affiliation":[{"name":"Inflammatory Diseases Unit, Roche Bioscience , Palo Alto, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,2,3]]},"reference":[{"key":"2023033100191535900_","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","article-title":"Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm","volume":"76","author":"Springer","year":"1994","journal-title":"Cell"},{"key":"2023033100191535900_","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0167-5699(95)80023-9","article-title":"High endothelial venules: specialized endothelium for lymphocyte migration","volume":"16","author":"Girard","year":"1995","journal-title":"Immunol. 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