{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:48:15Z","timestamp":1789645695404,"version":"4.0.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2006,2,3]],"date-time":"2006-02-03T00:00:00Z","timestamp":1138924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ministry of Education, Science, and Culture of Japan"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health, USA","doi-asserted-by":"publisher","award":["CA54464"],"award-info":[{"award-number":["CA54464"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health, USA","doi-asserted-by":"publisher","award":["CA81776"],"award-info":[{"award-number":["CA81776"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Concanavalin A (Con A)-induced hepatitis is a model for human T cell-mediated hepatitis. We evaluated the role of L-selectin and intercellular adhesion molecule-1 (ICAM-1) in this model by injecting Con A intravenously in mice lacking L-selectin (L-selectin\u2212\/\u2212), ICAM-1 (ICAM-1\u2212\/\u2212), or both (L-selectin\/ICAM-1\u2212\/\u2212). Blood and liver samples were collected 0, 8, 24, and 48 h after Con A treatment. Increases in plasma transaminase levels, which peaked 8 h after injection, were reduced significantly in L-selectin\u2212\/\u2212, ICAM-1\u2212\/\u2212, and L-selectin\/ICAM-1\u2212\/\u2212 mice compared with wild-type mice. Liver necrosis was more strongly inhibited in ICAM-1\u2212\/\u2212 mice than in L-selectin\u2212\/\u2212 mice but was most prominently reduced in L-selectin\/ICAM-1\u2212\/\u2212 mice, in parallel with decreased plasma transaminase levels. The reduced severity of hepatitis in the mutant mice correlated with decreases in numbers of liver CD4+ T cells but not numbers of CD8+ T cells or neutrophils. Following Con A treatment, L-selectin deficiency reduced liver mRNA expression of tumor necrosis factor-\u03b1, and ICAM-1 deficiency reduced expression of interleukin-4. By contrast, reductions in liver macrophage inhibitor protein-1\u03b1 mRNA occurred in all mutant mice. These results indicate that L-selectin and ICAM-1 contribute cooperatively to the development of Con A-induced hepatitis by regulating leukocyte infiltration and subsequent cytokine production.<\/jats:p>","DOI":"10.1189\/jlb.0905527","type":"journal-article","created":{"date-parts":[[2006,2,4]],"date-time":"2006-02-04T02:03:52Z","timestamp":1139018632000},"page":"696-705","source":"Crossref","is-referenced-by-count":18,"title":["L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury"],"prefix":"10.1093","volume":"79","author":[{"given":"Ayako","family":"Kawasuji","sequence":"first","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuka","family":"Horikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiyo","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A","family":"Steeber","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Wisconsin-Milwaukee , Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"Tedder","sequence":"additional","affiliation":[{"name":"Department of Immunology, Duke University Medical Center , Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Takehara","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,2,3]]},"reference":[{"key":"2023033022095628800_jlb0696-cit-B1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1172\/JCI115836","article-title":"A T cell-dependent experimental liver injury in mice inducible by concanavalin A","volume":"90","author":"Tiegs","year":"1992","journal-title":"J. Clin. Invest."},{"key":"2023033022095628800_jlb0696-cit-B2","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1084\/jem.179.5.1529","article-title":"T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6","volume":"179","author":"Mizuhara","year":"1994","journal-title":"J. Exp. Med."},{"key":"2023033022095628800_jlb0696-cit-B3","first-page":"190","article-title":"Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor","volume":"21","author":"Gantner","year":"1995","journal-title":"Hepatology"},{"key":"2023033022095628800_jlb0696-cit-B4","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1053\/gast.1996.v111.pm8690213","article-title":"Interferon \u03b3 plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A","volume":"111","author":"Kusters","year":"1996","journal-title":"Gastroenterology"},{"key":"2023033022095628800_jlb0696-cit-B5","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.4049\/jimmunol.159.3.1537","article-title":"Requirement of IL-4 and liver NK1+ T cells for concanavalin A-induced hepatic injury in mice","volume":"159","author":"Toyabe","year":"1997","journal-title":"J. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4049\/jimmunol.172.1.45","article-title":"Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis","volume":"172","author":"Bonder","year":"2004","journal-title":"J. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.191.1.105","article-title":"Augmentation of V\u03b114 NKT cell-mediated cytotoxicity by interleukin 4 in an autocrine mechanism resulting in the development of concanavalin A-induced hepatitis","volume":"191","author":"Kaneko","year":"2000","journal-title":"J. Exp. Med."},{"key":"2023033022095628800_jlb0696-cit-B8","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.1073\/pnas.040566697","article-title":"Critical contribution of liver natural killer T cells to a murine model of hepatitis","volume":"97","author":"Takeda","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033022095628800_jlb0696-cit-B9","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0092-8674(91)90279-8","article-title":"Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity","volume":"67","author":"Butcher","year":"1991","journal-title":"Cell"},{"key":"2023033022095628800_jlb0696-cit-B10","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4049\/jimmunol.155.2.525","article-title":"Leukocyte interactions with vascular endothelium: new insights into selectin-mediated attachment and rolling","volume":"155","author":"Ley","year":"1995","journal-title":"J. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B11","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1146\/annurev.ph.57.030195.004143","article-title":"Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration","volume":"57","author":"Springer","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"2023033022095628800_jlb0696-cit-B12","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1096\/fasebj.9.10.7542213","article-title":"The selectins: vascular adhesion molecules","volume":"9","author":"Tedder","year":"1995","journal-title":"FASEB J."},{"key":"2023033022095628800_jlb0696-cit-B13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nri1351","article-title":"Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation","volume":"4","author":"Ley","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B14","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/1074-7613(94)90076-0","article-title":"Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin (CD62L)-deficient mice","volume":"1","author":"Arbones","year":"1994","journal-title":"Immunity"},{"key":"2023033022095628800_jlb0696-cit-B15","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.4049\/jimmunol.158.11.5191","article-title":"L-selectin is involved in lymphocyte migration to sites of inflammation in the skin: delayed rejection of allografts in L-selectin-deficient mice","volume":"158","author":"Tang","year":"1997","journal-title":"J. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B16","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1084\/jem.181.6.2259","article-title":"L-selectin-deficient mice have impaired leukocyte recruitment into inflammatory sites","volume":"181","author":"Tedder","year":"1995","journal-title":"J. Exp. Med."},{"key":"2023033022095628800_jlb0696-cit-B17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1084\/jem.183.2.589","article-title":"Impaired primary T cell responses in L-selectin-deficient mice","volume":"183","author":"Xu","year":"1996","journal-title":"J. Exp. Med."},{"key":"2023033022095628800_jlb0696-cit-B18","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1084\/jem.184.6.2341","article-title":"The route of antigen entry determines the requirement for L-selectin during immune responses","volume":"184","author":"Catalina","year":"1996","journal-title":"J. Exp. Med."},{"key":"2023033022095628800_jlb0696-cit-B19","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1084\/jem.181.2.669","article-title":"Sequential contribution of L- and P-selectin to leukocyte rolling in vivo","volume":"181","author":"Ley","year":"1995","journal-title":"J. Exp. Med."},{"key":"2023033022095628800_jlb0696-cit-B20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.4049\/jimmunol.137.1.245","article-title":"Induction by IL-1 and interferon-\u03b3: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1)","volume":"137","author":"Dustin","year":"1986","journal-title":"J. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B21","doi-asserted-by":"crossref","first-page":"7562","DOI":"10.1073\/pnas.95.13.7562","article-title":"Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression","volume":"95","author":"Steeber","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033022095628800_jlb0696-cit-B22","doi-asserted-by":"crossref","first-page":"8529","DOI":"10.1073\/pnas.90.18.8529","article-title":"Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1","volume":"90","author":"Sligh","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033022095628800_jlb0696-cit-B23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1084\/jem.180.1.95","article-title":"Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice","volume":"180","author":"Xu","year":"1994","journal-title":"J. Exp. Med."},{"key":"2023033022095628800_jlb0696-cit-B24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0002-9440(10)64534-8","article-title":"Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression","volume":"157","author":"Nagaoka","year":"2000","journal-title":"Am. J. Pathol."},{"key":"2023033022095628800_jlb0696-cit-B25","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.4049\/jimmunol.163.4.2176","article-title":"Leukocyte entry into sites of inflammation requires overlapping interaction between the L-selectin and ICAM-1 pathways","volume":"163","author":"Steeber","year":"1999","journal-title":"J. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B26","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0002-9440(10)64439-2","article-title":"Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis","volume":"161","author":"Hamaguchi","year":"2002","journal-title":"Am. J. Pathol."},{"key":"2023033022095628800_jlb0696-cit-B27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/hep.510310115","article-title":"Sublobular veins as the main site of lymphocyte adhesion\/transmigration and adhesion molecule expression in the porto-sinusoidal-hepatic venous system during concanavalin A-induced hepatitis in mice","volume":"31","author":"Morikawa","year":"2000","journal-title":"Hepatology"},{"key":"2023033022095628800_jlb0696-cit-B28","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1189\/jlb.72.2.262","article-title":"Concanavalin-A-induced liver injury is severely impaired in mice deficient in P-selectin","volume":"72","author":"Massaguer","year":"2002","journal-title":"J. Leukoc. Biol."},{"key":"2023033022095628800_jlb0696-cit-B29","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/hep.510240338","article-title":"Concanavalin A induces perforin-mediated but not Fas-mediated hepatic injury","volume":"24","author":"Watanabe","year":"1996","journal-title":"Hepatology"},{"key":"2023033022095628800_jlb0696-cit-B30","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.4049\/jimmunol.166.2.1300","article-title":"TNF-\u03b1-induced expression of adhesion molecules in the liver is under the control of TNFR1\u2014relevance for concanavalin A-induced hepatitis","volume":"166","author":"Wolf","year":"2001","journal-title":"J. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B31","doi-asserted-by":"crossref","first-page":"7087","DOI":"10.4049\/jimmunol.169.12.7087","article-title":"Essential role of the adhesion receptor LFA-1 for T cell-dependent fulminant hepatitis","volume":"169","author":"Matsumoto","year":"2002","journal-title":"J. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B32","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.4049\/jimmunol.154.11.6080","article-title":"Novel isoforms of murine intercellular adhesion molecule-1 generated by alternative RNA splicing","volume":"154","author":"King","year":"1995","journal-title":"J. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1525-1578(10)60652-6","article-title":"A novel method to compensate for different amplification efficiencies between patient DNA samples in quantitative real-time PCR","volume":"3","author":"Meijerink","year":"2001","journal-title":"J. Mol. Diagn."},{"key":"2023033022095628800_jlb0696-cit-B34","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1172\/JCI504","article-title":"Concanavalin A-induced liver injury triggers hepatocyte proliferation","volume":"101","author":"Trautwein","year":"1998","journal-title":"J. Clin. Invest."},{"key":"2023033022095628800_jlb0696-cit-B35","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/S0002-9440(10)64804-3","article-title":"Importance of Kupffer cells for T-cell-dependent liver injury in mice","volume":"157","author":"Schumann","year":"2000","journal-title":"Am. J. Pathol."},{"key":"2023033022095628800_jlb0696-cit-B36","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.4049\/jimmunol.159.3.1418","article-title":"Suppression of concanavalin A-induced hepatitis in IFN-\u03b3(\u2013\/\u2013) mice, but not in TNF-\u03b1(\u2013\/\u2013) mice: role for IFN-\u03b3 in activating apoptosis of hepatocytes","volume":"159","author":"Tagawa","year":"1997","journal-title":"J. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B37","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/hep.510270227","article-title":"Strain difference in the induction of T-cell activation-associated, interferon \u03b3-dependent hepatic injury in mice","volume":"27","author":"Mizuhara","year":"1998","journal-title":"Hepatology"},{"key":"2023033022095628800_jlb0696-cit-B38","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1046\/j.1440-1711.2002.01065.x","article-title":"Biology and significance of T-cell apoptosis in the liver","volume":"80","author":"Park","year":"2002","journal-title":"Immunol. Cell Biol."},{"key":"2023033022095628800_jlb0696-cit-B39","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0168-8278(05)80072-8","article-title":"The cell adhesion molecules of hepatic sinusoidal endothelial cells","volume":"20","author":"Scoazec","year":"1994","journal-title":"J. Hepatol."},{"key":"2023033022095628800_jlb0696-cit-B40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s004280050233","article-title":"Morphological and functional alterations to sinusoidal endothelial cells in the early phase of endotoxin-induced liver failure after partial hepatectomy in rats","volume":"433","author":"Yachida","year":"1998","journal-title":"Virchows Arch."},{"key":"2023033022095628800_jlb0696-cit-B41","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/hep.510260318","article-title":"Intercellular adhesion molecule-1 and CD18 are involved in neutrophil adhesion and its cytotoxicity to cultured sinusoidal endothelial cells in rats","volume":"26","author":"Sakamoto","year":"1997","journal-title":"Hepatology"},{"key":"2023033022095628800_jlb0696-cit-B42","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.4049\/jimmunol.160.8.3978","article-title":"Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma","volume":"160","author":"Yoong","year":"1998","journal-title":"J. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B43","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/hep.1840050421","article-title":"Localization of increased hepatic vascular resistance in liver cirrhosis","volume":"5","author":"Shibayama","year":"1985","journal-title":"Hepatology"},{"key":"2023033022095628800_jlb0696-cit-B44","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1172\/JCI117952","article-title":"Therapeutic potential of inhibiting leukocyte rolling in ischemia\/reperfusion","volume":"95","author":"Kubes","year":"1995","journal-title":"J. Clin. Invest."},{"key":"2023033022095628800_jlb0696-cit-B45","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1172\/JCI119468","article-title":"A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature. J","volume":"99","author":"Wong","year":"1997","journal-title":"Clin. Invest."},{"key":"2023033022095628800_jlb0696-cit-B46","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.immuni.2005.06.007","article-title":"Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: a role for \u03b1-4 integrin and vascular adhesion protein-1","volume":"23","author":"Bonder","year":"2005","journal-title":"Immunity"},{"key":"2023033022095628800_jlb0696-cit-B47","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.4049\/jimmunol.167.7.3944","article-title":"Chronic inflammation and protection from acute hepatitis in transgenic mice expressing TNF in endothelial cells","volume":"167","author":"Willuweit","year":"2001","journal-title":"J. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B48","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0168-8278(99)80159-7","article-title":"Inhibition of concanavalin A-induced hepatic injury of mice by bacterial lipopolysaccharide via the induction of IL-6 and the subsequent reduction of IL-4: the cytokine milieu of concanavalin A hepatitis","volume":"31","author":"Nishikage","year":"1999","journal-title":"J. Hepatol."},{"key":"2023033022095628800_jlb0696-cit-B49","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.4049\/jimmunol.171.6.3233","article-title":"Crucial role of IL-4\/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes","volume":"171","author":"Jaruga","year":"2003","journal-title":"J. Immunol."},{"key":"2023033022095628800_jlb0696-cit-B50","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/path.1298","article-title":"Early up-regulation of chemokine expression in fulminant hepatic failure","volume":"199","author":"Leifeld","year":"2003","journal-title":"J. Pathol."},{"key":"2023033022095628800_jlb0696-cit-B51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.187.1.1","article-title":"Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1\u03b1 (MIP-1\u03b1)-dependent pathways","volume":"187","author":"Salazar-Mather","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023033022095628800_jlb0696-cit-B52","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1002\/eji.200425071","article-title":"CCL3\/MIP-1\u03b1 is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4(+) T cells to the liver","volume":"34","author":"Ajuebor","year":"2004","journal-title":"Eur. J. Immunol."}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/79\/4\/696\/49643631\/jlb0696.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/79\/4\/696\/49643631\/jlb0696.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:32:59Z","timestamp":1680222779000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/79\/4\/696\/6922740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,3]]},"references-count":52,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2006,2,3]]},"published-print":{"date-parts":[[2006,2,3]]}},"URL":"https:\/\/doi.org\/10.1189\/jlb.0905527","relation":{},"ISSN":["1938-3673","0741-5400"],"issn-type":[{"value":"1938-3673","type":"electronic"},{"value":"0741-5400","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,4]]},"published":{"date-parts":[[2006,2,3]]}}}