{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T20:40:12Z","timestamp":1771533612082,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ministero Pubblica Istruzione"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In the present study, by comparing the responses in wild-type (WT) mice and mice lacking [knockout (KO)] the 5-lipoxygenase (5-LO), we investigated the role played by 5-LO in the development of acute inflammation. When compared with carragenan-treated 5-LOWT mice, 5-LOKO mice, which had received carrageenan, exhibited a reduced degree of pleural exudation, polymorphonuclear cell migration. Lung myeloperoxidase activity, an index of neutrophil infiltration, was significantly reduced in 5-LOKO mice in comparison with 5-LOWT. Lung-tissue sections from carrageenan-treated 5-LOWT mice showed positive staining for intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), P-selectin, and E-selectin, which were mainly localized around vessels. The intensity and degree of ICAM-1, VCAM-1, P-selectin, and E-selectin were markedly reduced in tissue section from carrageenan-5-LOKO mice, which also improved the histological status of the inflamed lungs. Taken together, our results clearly demonstrate that 5-LO modulates neutrophil infiltration in the acute lung inflammation.<\/jats:p>","DOI":"10.1189\/jlb.1002477","type":"journal-article","created":{"date-parts":[[2003,5,28]],"date-time":"2003-05-28T19:36:40Z","timestamp":1054150600000},"page":"739-746","source":"Crossref","is-referenced-by-count":27,"title":["5-Lipoxygenase knockout mice exhibit a resistance to pleurisy and lung injury caused by carrageenan"],"prefix":"10.1093","volume":"73","author":[{"given":"Salvatore","family":"Cuzzocrea","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine and Pharmacology, University \u201cFederico II\u201d , Napoli , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonietta","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Experimental Pharmacology, University \u201cFederico II\u201d , Napoli , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Serraino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine and Pharmacology, University \u201cFederico II\u201d , Napoli , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Mazzon","sequence":"additional","affiliation":[{"name":"Department of Biomorphology, School of Medicine, University of Messina Torre Biologica, Policlinico Universitario , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosanna","family":"Di Paola","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine and Pharmacology, University \u201cFederico II\u201d , Napoli , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Dugo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine and Pharmacology, University \u201cFederico II\u201d , Napoli , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Genovese","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine and Pharmacology, University \u201cFederico II\u201d , Napoli , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Calabr\u00f2","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine and Pharmacology, University \u201cFederico II\u201d , Napoli , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achille P","family":"Caputi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine and Pharmacology, University \u201cFederico II\u201d , Napoli , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Sautebin","sequence":"additional","affiliation":[{"name":"Department of Experimental Pharmacology, University \u201cFederico II\u201d , Napoli , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,6,1]]},"reference":[{"key":"2023033018595306400_jlb0739-cit-b1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.7326\/0003-4819-121-9-199411010-00010","article-title":"The role of leukotrienes in inflammation","volume":"121","author":"Henderson","year":"1994","journal-title":"Ann. 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