{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:49:43Z","timestamp":1788871783254,"version":"build-2803163510"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T00:00:00Z","timestamp":1675728000000},"content-version":"vor","delay-in-days":6644,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000078","name":"Mater Medical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000078","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CD123hi CD11c\u2212 dendritic cells (CD123hi DC) are a distinct subset of human DC present in bone marrow, blood, lymphoid organs, and peripheral tissues. Pathogen stimulation, cytokine, or CD40 ligation induces CD123hi DC maturation, involving a shift from their innate immune to cognate antigen-presenting functions. In this study, we revealed that blood CD123hi DC in the presence of cytokine (granulocyte macrophage-colony stimulating factor and interleukin-3) undergo progressive, step-wise maturation through an \u201cearly\u201d stage, delineated by expression of the antigen detected by the new monoclonal antibody CMRF58 (CD123hiCMRF58+CD40\u2212CD86\u2212CD83\u2212) to the \u201clate\u201d stage with costimulatory antigen expression (CD123hiCMRF58+CD40+CD86+CD83+\/\u2212). In this early stage, cytokine-maintained CD123hi DC do not display changes in their morphology, no longer produce interferon-\u03b1 (IFN-\u03b1) in response to bacteria, and develop the capacity to induce proliferation and polarization of allogeneic T cells. CD123hiCMRF58+ DC, phenotypically similar to in vitro cytokine-maintained CD123hi DC, were not detected in tonsil but are present in allergen-challenged nasal mucosa of allergic individuals. Thus, CD123hi DC in certain tissue environments such as allergen-challenged nasal mucosa share a common CD123hiCMRF58+ phenotype with in vitro cytokine-maintained blood CD123hi DC characterized by lack of IFN-\u03b1 production.<\/jats:p>","DOI":"10.1189\/jlb.1004559","type":"journal-article","created":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T20:13:32Z","timestamp":1101759212000},"page":"344-351","source":"Crossref","is-referenced-by-count":3,"title":["The CMRF58 antibody recognizes a subset of CD123hi dendritic cells in allergen-challenged mucosa"],"prefix":"10.1093","volume":"77","author":[{"given":"Slavica","family":"Vuckovic","sequence":"first","affiliation":[{"name":"Mater Medical Research Institute , South Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Khalil","sequence":"additional","affiliation":[{"name":"Mater Medical Research Institute , South Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Angel","sequence":"additional","affiliation":[{"name":"Mater Medical Research Institute , South Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frode","family":"Jahnsen","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Rikshospitalet , Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iona","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Mater Medical Research Institute , South Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Boyce","sequence":"additional","affiliation":[{"name":"Mater Medical Research Institute , South Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Hock","sequence":"additional","affiliation":[{"name":"Hematology\/Immunology Research Group, Christchurch Hospital , New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek N J","family":"Hart","sequence":"additional","affiliation":[{"name":"Mater Medical Research Institute , South Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,11,29]]},"reference":[{"key":"2023033101035891000_","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1182\/blood.V90.9.3245","article-title":"Dendritic cells: unique leukocyte populations, which control the primary immune response","volume":"90","author":"Hart","year":"1997","journal-title":"Blood"},{"key":"2023033101035891000_","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1182\/blood-2001-11-0097","article-title":"Characterization of human blood dendritic cell subsets","volume":"100","author":"MacDonald","year":"2002","journal-title":"Blood"},{"key":"2023033101035891000_","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0198-8859(02)00752-8","article-title":"Plasmacytoid dendritic cells: from specific surface markers to specific cellular functions","volume":"63","author":"Dzionek","year":"2002","journal-title":"Hum. 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