{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:04:53Z","timestamp":1791234293291,"version":"4.1.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T00:00:00Z","timestamp":1150934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Paneth cells are secretory intestinal epithelial cells located at the base of the crypts of Lieberk\u00fchn in the small intestine. They display prominent cytoplasmic granules, containing antibacterial proteins such as lysozyme, secretory phospholipase A2 type IIA, and \u03b1-defensins, which are released into the intestinal lumen in response to a range of stimuli. In this, they resemble circulating leukocytes, which also elaborate and secrete lysozyme and \u03b1-defensins as part of an antibacterial defense function, and the resemblance is sustained at other levels. The cells also strongly and specifically express the NOD2 gene product, one of an emerging family of critical, intracellular mediators of innate immune responses, which is also highly expressed in peripheral blood mononuclear cells, and they express RNA for tumor necrosis factor \u03b1, a major myelomonocytic cell-derived cytokine, which has a crucial role in the pathogenesis of diseases such as rheumatoid arthritis and Crohn's disease (CD). Thus, these cells, which are derived from the pluripotent intestinal epithelial stem-cell lineage, are sessile, resident host-defense cells, which may share with leukocytes the beneficial function of secreting antimicrobial peptides, aswell as the potentially harmful capacity for promoting inflammation and tissue damage. Paneth cells are most abundant in the distal small intestine, which is the region most frequently affected by CD, and there is great interest in the potential role of these cells in this condition. This brief review summarizes current knowledge and speculates on how the study of these fascinating cells might be advanced.<\/jats:p>","DOI":"10.1189\/jlb.1005556","type":"journal-article","created":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T20:43:36Z","timestamp":1151009016000},"page":"500-508","source":"Crossref","is-referenced-by-count":76,"title":["Paneth cells: leukocyte-like mediators of innate immunity in the intestine"],"prefix":"10.1093","volume":"80","author":[{"given":"Satish","family":"Keshav","sequence":"first","affiliation":[{"name":"Department of Medicine, Centre for Gastroenterology, Royal Free and University College Medical School, UCL , London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,6,22]]},"reference":[{"key":"2023033007513495900_jlb0500-cit-B1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF02955706","article-title":"Ueber die secernirenden Zellen des D\u00fcnndarm-Epithels","volume":"31","author":"Paneth","year":"1888","journal-title":"Archiv. Mikroskop. Anat."},{"key":"2023033007513495900_jlb0500-cit-B2","doi-asserted-by":"crossref","first-page":"6227","DOI":"10.1073\/pnas.85.17.6227","article-title":"Cloning the human lysozyme cDNA: inverted Alu repeat in the mRNA and in situ hybridization for macrophages and Paneth cells","volume":"85","author":"Chung","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033007513495900_jlb0500-cit-B3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0016-5085(75)80052-7","article-title":"Atrophy of villi with hypertrophy and hyperplasia of Paneth cells in isolated (thiry-Vella) ileal loops in rabbits. Light-microscopic studies","volume":"68","author":"Keren","year":"1975","journal-title":"Gastroenterology"},{"key":"2023033007513495900_jlb0500-cit-B4","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1136\/gut.10.10.804","article-title":"The Paneth cell in disease","volume":"10","author":"Lewin","year":"1969","journal-title":"Gut"},{"key":"2023033007513495900_jlb0500-cit-B5","author":"Day","year":"2003"},{"key":"2023033007513495900_jlb0500-cit-B6","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0140-6736(67)91245-7","article-title":"Paneth-cell function","volume":"1","author":"Creamer","year":"1967","journal-title":"Lancet"},{"key":"2023033007513495900_jlb0500-cit-B7","doi-asserted-by":"crossref","first-page":"6232","DOI":"10.1073\/pnas.85.17.6232","article-title":"Mouse lysozyme M gene: isolation, characterization, and expression studies","volume":"85","author":"Cross","year":"1988","journal-title":"Proc. Natl. Acad. Sci. 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Gastroenterol."},{"key":"2023033007513495900_jlb0500-cit-B14","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1177\/002215540104900611","article-title":"Cellular localization of group IIA phospholipase A2 in rats","volume":"49","author":"Yoshikawa","year":"2001","journal-title":"J. Histochem. Cytochem."},{"key":"2023033007513495900_jlb0500-cit-B15","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1515\/CCLM.2000.194","article-title":"Presence of group IIa secretory phospholipase A2 in mast cells and macrophages in normal human ileal submucosa and in Crohn's disease","volume":"38","author":"Lilja","year":"2000","journal-title":"Clin. Chem. Lab. Med."},{"key":"2023033007513495900_jlb0500-cit-B16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1084\/jem.171.1.327","article-title":"Tumor necrosis factor mRNA localized to Paneth cells of normal murine intestinal epithelium by in situ hybridization","volume":"171","author":"Keshav","year":"1990","journal-title":"J. Exp. Med."},{"key":"2023033007513495900_jlb0500-cit-B17","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/BF00157963","article-title":"Ultrastructural localization of tumor necrosis factor-\u03b1","volume":"26","author":"Schmauder-Chock","year":"1994","journal-title":"Histochem. J."},{"key":"2023033007513495900_jlb0500-cit-B18","first-page":"1858","article-title":"Cellular localization of tumor necrosis factor (TNF)-\u03b1 transcripts in normal bowel and in necrotizing enterocolitis. TNF gene expression by Paneth cells, intestinal eosinophils, and macrophages","volume":"142","author":"Tan","year":"1993","journal-title":"Am. J. Pathol."},{"key":"2023033007513495900_jlb0500-cit-B19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0016-5085(03)00661-9","article-title":"Crohn's disease and the NOD2 gene: a role for Paneth cells","volume":"125","author":"Lala","year":"2003","journal-title":"Gastroenterology"},{"key":"2023033007513495900_jlb0500-cit-B20","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.bbrc.2003.11.009","article-title":"Identification of GM-CSF in Paneth cells using single-cell RT-PCR","volume":"312","author":"Fukuzawa","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023033007513495900_jlb0500-cit-B21","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1056\/NEJMoa041109","article-title":"Sargramostim for active Crohn's disease","volume":"352","author":"Korzenik","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"2023033007513495900_jlb0500-cit-B22","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1136\/gut.52.11.1591","article-title":"Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis","volume":"52","author":"Ogura","year":"2003","journal-title":"Gut"},{"key":"2023033007513495900_jlb0500-cit-B23","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1074\/jbc.M008072200","article-title":"Nod2, a Nod1\/Apaf-1 family member that is restricted to monocytes and activates NF-\u03baB","volume":"276","author":"Ogura","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2023033007513495900_jlb0500-cit-B24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0092-8674(02)01015-2","article-title":"\u03b2-Catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB\/ephrinB","volume":"111","author":"Batlle","year":"2002","journal-title":"Cell"},{"key":"2023033007513495900_jlb0500-cit-B25","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.gastro.2005.06.007","article-title":"Expression pattern of Wnt signaling components in the adult intestine","volume":"129","author":"Gregorieff","year":"2005","journal-title":"Gastroenterology"},{"key":"2023033007513495900_jlb0500-cit-B26","first-page":"171","volume-title":"The Innate Immune Response to Infection","author":"Keshav","year":"2004"},{"key":"2023033007513495900_jlb0500-cit-B27","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s00018-002-8412-z","article-title":"The multifaceted Paneth cell","volume":"59","author":"Porter","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"2023033007513495900_jlb0500-cit-B28","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1172\/JCI112120","article-title":"Defensins. Natural peptide antibiotics of human neutrophils","volume":"76","author":"Ganz","year":"1985","journal-title":"J. Clin. Invest."},{"key":"2023033007513495900_jlb0500-cit-B29","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1091\/mbc.6.7.851","article-title":"The metalloproteinase matrilysin is preferentially expressed by epithelial cells in a tissue-restricted pattern in the mouse","volume":"6","author":"Wilson","year":"1995","journal-title":"Mol. Biol. Cell"},{"key":"2023033007513495900_jlb0500-cit-B30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.286.5437.113","article-title":"Regulation of intestinal \u03b1-defensin activation by the metalloproteinase matrilysin in innate host defense","volume":"286","author":"Wilson","year":"1999","journal-title":"Science"},{"key":"2023033007513495900_jlb0500-cit-B31","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/77783","article-title":"Secretion of microbicidal \u03b1-defensins by intestinal Paneth cells in response to bacteria","volume":"1","author":"Ayabe","year":"2000","journal-title":"Nat. Immunol."},{"key":"2023033007513495900_jlb0500-cit-B32","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nature01520","article-title":"Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin","volume":"422","author":"Salzman","year":"2003","journal-title":"Nature"},{"key":"2023033007513495900_jlb0500-cit-B33","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/ni797","article-title":"Paneth cell trypsin is the processing enzyme for human defensin-5","volume":"3","author":"Ghosh","year":"2002","journal-title":"Nat. Immunol."},{"key":"2023033007513495900_jlb0500-cit-B34","doi-asserted-by":"crossref","first-page":"23729","DOI":"10.1074\/jbc.272.38.23729","article-title":"Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice","volume":"272","author":"Garabedian","year":"1997","journal-title":"J. Biol. Chem."},{"key":"2023033007513495900_jlb0500-cit-B35","doi-asserted-by":"crossref","first-page":"15451","DOI":"10.1073\/pnas.202604299","article-title":"Developmental regulation of intestinal angiogenesis by endogenous microbes via Paneth cells","volume":"99","author":"Stappenbeck","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033007513495900_jlb0500-cit-B36","doi-asserted-by":"crossref","first-page":"19902","DOI":"10.1074\/jbc.M311821200","article-title":"Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response","volume":"279","author":"Lin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2023033007513495900_jlb0500-cit-B37","doi-asserted-by":"crossref","first-page":"8585","DOI":"10.1073\/pnas.94.16.8585","article-title":"Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3","volume":"94","author":"Lencer","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033007513495900_jlb0500-cit-B38","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.286.5439.525","article-title":"\u03b2-Defensins: linking innate and adaptive immunity through dendritic and T cell CCR6","volume":"286","author":"Yang","year":"1999","journal-title":"Science"},{"key":"2023033007513495900_jlb0500-cit-B39","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1172\/JCI117704","article-title":"Bactericidal properties of murine intestinal phospholipase A2","volume":"95","author":"Harwig","year":"1995","journal-title":"J. Clin. Invest."},{"key":"2023033007513495900_jlb0500-cit-B40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/jsre.1996.0003","article-title":"Serum phospholipase A2 in patients with multiple organ failure","volume":"60","author":"Nyman","year":"1996","journal-title":"J. Surg. Res."},{"key":"2023033007513495900_jlb0500-cit-B41","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.4049\/jimmunol.165.5.2790","article-title":"Type IIA secretory phospholipase A2 up-regulates cyclooxygenase-2 and amplifies cytokine-mediated prostaglandin production in human rheumatoid synoviocytes","volume":"165","author":"Bidgood","year":"2000","journal-title":"J. Immunol."},{"key":"2023033007513495900_jlb0500-cit-B42","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1161\/01.ATV.19.5.1284","article-title":"Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2","volume":"19","author":"Ivandic","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033007513495900_jlb0500-cit-B43","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/ng0997-88","article-title":"Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis","volume":"17","author":"Cormier","year":"1997","journal-title":"Nat. Genet."},{"key":"2023033007513495900_jlb0500-cit-B44","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0968-0004(00)89102-1","article-title":"AU-rich elements: characterization and importance in mRNA degradation","volume":"20","author":"Chen","year":"1995","journal-title":"Trends Biochem. Sci."},{"key":"2023033007513495900_jlb0500-cit-B45","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/003655202753416803","article-title":"Involvement of tumor necrosis factor \u03b1 in intestinal epithelial cell proliferation following Paneth cell destruction","volume":"37","author":"Seno","year":"2002","journal-title":"Scand. J. Gastroenterol."},{"key":"2023033007513495900_jlb0500-cit-B46","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMra020831","article-title":"Inflammatory bowel disease","volume":"347","author":"Podolsky","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"Suppl. 4","key":"2023033007513495900_jlb0500-cit-B47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-2036.1999.00024.x","article-title":"Review article: targeting TNF \u03b1 as a key cytokine in the inflammatory processes of Crohn's disease\u2014the mechanisms of action of infliximab","volume":"13","author":"van Deventer","year":"1999","journal-title":"Aliment. Pharmacol. Ther."},{"key":"2023033007513495900_jlb0500-cit-B48","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1074-7613(00)80038-2","article-title":"Impaired on\/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies","volume":"10","author":"Kontoyiannis","year":"1999","journal-title":"Immunity"},{"key":"2023033007513495900_jlb0500-cit-B49","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrm1019","article-title":"NALPs: a novel protein family involved in inflammation","volume":"4","author":"Tschopp","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2023033007513495900_jlb0500-cit-B50","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","article-title":"A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature"},{"key":"2023033007513495900_jlb0500-cit-B51","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease","volume":"411","author":"Hugot","year":"2001","journal-title":"Nature"},{"key":"2023033007513495900_jlb0500-cit-B52","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/S0140-6736(00)05063-7","article-title":"Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations","volume":"357","author":"Hampe","year":"2001","journal-title":"Lancet"},{"key":"2023033007513495900_jlb0500-cit-B53","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1053\/gast.2002.32413","article-title":"The molecular classification of the clinical manifestations of Crohn's disease","volume":"122","author":"Ahmad","year":"2002","journal-title":"Gastroenterology"},{"key":"2023033007513495900_jlb0500-cit-B54","doi-asserted-by":"crossref","first-page":"8869","DOI":"10.1074\/jbc.C200651200","article-title":"Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection","volume":"278","author":"Girardin","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2023033007513495900_jlb0500-cit-B55","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1462-5822.2003.00304.x","article-title":"Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation","volume":"5","author":"Chamaillard","year":"2003","journal-title":"Cell. Microbiol."},{"key":"2023033007513495900_jlb0500-cit-B56","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1136\/gut.2003.032805","article-title":"NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal \u03b1-defensin expression","volume":"53","author":"Wehkamp","year":"2004","journal-title":"Gut"},{"key":"2023033007513495900_jlb0500-cit-B57","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1126\/science.1104911","article-title":"Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract","volume":"307","author":"Kobayashi","year":"2005","journal-title":"Science"},{"key":"2023033007513495900_jlb0500-cit-B58","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1128\/IAI.69.9.5529-5537.2001","article-title":"Adherent invasive Escherichia coli strains from patients with Crohn's disease survive and replicate within macrophages without inducing host cell death","volume":"69","author":"Glasser","year":"2001","journal-title":"Infect. Immun."},{"key":"2023033007513495900_jlb0500-cit-B59","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/s11894-004-0072-8","article-title":"Advances in medical therapy for Crohn's disease","volume":"6","author":"D'Haens","year":"2004","journal-title":"Curr. Gastroenterol. Rep."},{"key":"2023033007513495900_jlb0500-cit-B60","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/00042737-200502000-00003","article-title":"Antibiotics for inflammatory bowel disease: do they work?","volume":"17","author":"Guslandi","year":"2005","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"2023033007513495900_jlb0500-cit-B61","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1365-2249.2001.01589.x","article-title":"Mucosal T cells regulate Paneth and intermediate cell numbers in the small intestine of T. spiralis-infected mice","volume":"126","author":"Kamal","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"2023033007513495900_jlb0500-cit-B62","first-page":"407","article-title":"Selective killing of Paneth cells by intravenous administration of dithizone in rats","volume":"72","author":"Sawada","year":"1991","journal-title":"Int. J. Exp. Pathol."},{"key":"2023033007513495900_jlb0500-cit-B63","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/ncb1240","article-title":"Wnt signaling induces maturation of Paneth cells in intestinal crypts","volume":"7","author":"van Es","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"2023033007513495900_jlb0500-cit-B64","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1242\/dev.01700","article-title":"Crypt-restricted proliferation and commitment to the Paneth cell lineage following Apc loss in the mouse intestine","volume":"132","author":"Andreu","year":"2005","journal-title":"Development"},{"key":"2023033007513495900_jlb0500-cit-B65","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF00222296","article-title":"Atropine inhibits the degranulation of Paneth cells in ex-germ-free mice","volume":"253","author":"Satoh","year":"1988","journal-title":"Cell Tissue Res."},{"key":"2023033007513495900_jlb0500-cit-B66","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00215451","article-title":"Effect of live and heat-killed bacteria on the secretory activity of Paneth cells in germ-free mice","volume":"251","author":"Satoh","year":"1988","journal-title":"Cell Tissue Res."},{"key":"2023033007513495900_jlb0500-cit-B67","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1172\/JCI12559","article-title":"The SAMP1\/Yit mouse: another step closer to modeling human inflammatory bowel disease","volume":"107","author":"Strober","year":"2001","journal-title":"J. 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