{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:17:51Z","timestamp":1760548671936,"version":"3.37.3"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2008,3,25]],"date-time":"2008-03-25T00:00:00Z","timestamp":1206403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100023171","name":"Life Sciences Research Board","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100023171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Government of India"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>APCs express MHC-II molecules. Binding of enterotoxins to MHC-II generates a signal resulting in the production of TNF-\u03b1 that mediates toxic shock syndrome. However, the signaling events that lead to TNF-\u03b1 production in macrophages are not well understood. We, for the first time, demonstrate that binding of staphylococcal enterotoxin B to MHC-II results in activation of TNF-\u03b1-converting enzyme, epidermal growth factor receptor, p38MAPK, and NF-\u03baB inducing biphasic TNF-\u03b1 production. Paraformaldehyde-fixed, peptide-specific T cells also activate MHC-II signaling and TNF-\u03b1 induction in peptide-pulsed macrophages. Our results reveal a novel MHC-II signaling and bidirectional macrophage-T cell interaction regulating macrophage functions. This knowledge may help to develop novel, macrophage-directed, therapeutic strategies.<\/jats:p>","DOI":"10.1189\/jlb.1007686","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T00:35:02Z","timestamp":1206491702000},"page":"1363-1369","source":"Crossref","is-referenced-by-count":11,"title":["SEB-induced signaling in macrophages leads to biphasic TNF-\u03b1"],"prefix":"10.1093","volume":"83","author":[{"given":"Aslam Ali","family":"Khan","sequence":"first","affiliation":[{"name":"National Centre for Cell Science , Ganeshkhind, Pune , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Martin","sequence":"additional","affiliation":[{"name":"National Centre for Cell Science , Ganeshkhind, Pune , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhaskar","family":"Saha","sequence":"additional","affiliation":[{"name":"National Centre for Cell Science , Ganeshkhind, Pune , India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,3,25]]},"reference":[{"key":"2023033005125374300_","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev.iy.03.040185.001321","article-title":"T-lymphocyte recognition of antigen in association with the gene products of the major histocompatibility complex","volume":"3","author":"Schwartz","year":"1985","journal-title":"Annu. 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