{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:28:46Z","timestamp":1791404926665,"version":"4.3.3"},"reference-count":131,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2009,2,23]],"date-time":"2009-02-23T00:00:00Z","timestamp":1235347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alterations in the capability of CF lung macrophage to respond and clear airway pathogens might contribute to the development of lung disease in cystic fibrosis.<\/jats:p>\n               <jats:p>Several S100 Ca2+\u2013binding proteins undergo various post\u2013translational modifications that may alter their intracellular and extracellular functions. S100A8 and S100A9, two members of this family, are particularly susceptible to oxidative modification. These proteins, abundantly expressed in neutrophils and activated macrophages, are associated with acute and chronic inflammatory conditions, including microbial infections, cystic fibrosis, rheumatoid arthritis, and atherosclerosis. They have diverse intracellular roles including NADPH oxidase activation and arachidonic acid transport and can be secreted via a Golgi\u2013independent pathway to exert extracellular functions. Many pro\u2013inflammatory functions have been described for S100A8 and S100A9, but they are also implicated in anti\u2013inflammatory roles in wound\u2013healing and protection against excessive oxidative tissue damage, the latter as a result of their exquisite capacity to scavenge oxidants. Similarly, their genes are induced by proinflammatory (LPS and TNF\u2013\u03b1) stimuli, but induction is IL\u201310\u2013dependent, and anti\u2013inflammatory glucocorticoids induce or amplify expression. S100A8 and S100A9 were described recently as damage\u2013associated molecular pattern molecules, which provide a novel, conceptual framework for understanding their functions. However, because of this designation, recent reviews focus solely on their pro\u2013inflammatory functions. Here, we summarize the mounting evidence from functional and gene regulation studies that these proteins may also play protective roles. This review offers an explanation for the disparate, functional roles of S100A8 and S100A9 based on emerging data that post\u2013translational, oxidative modifications may act as a regulatory switch.<\/jats:p>","DOI":"10.1189\/jlb.1008608","type":"journal-article","created":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T02:10:18Z","timestamp":1235441418000},"page":"577-587","source":"Crossref","is-referenced-by-count":142,"title":["Oxidative modifications of S100 proteins: functional regulation by redox"],"prefix":"10.1093","volume":"86","author":[{"given":"Su Yin","family":"Lim","sequence":"first","affiliation":[{"name":"The Centre for Infection and Inflammation Research, University of New South Wales , Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Raftery","sequence":"additional","affiliation":[{"name":"Bioanalytical Mass Spectrometry Facility, School of Medical Sciences, University of New South Wales , Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Goyette","sequence":"additional","affiliation":[{"name":"The Centre for Infection and Inflammation Research, University of New South Wales , Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Hsu","sequence":"additional","affiliation":[{"name":"The Centre for Infection and Inflammation Research, University of New South Wales , Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn L","family":"Geczy","sequence":"additional","affiliation":[{"name":"The Centre for Infection and Inflammation Research, University of New South Wales , Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,2,23]]},"reference":[{"key":"2023032913020556900_jlb0577-cit-B1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ygeno.2004.02.002","article-title":"Probing the S100 protein family through genomic and functional analysis","volume":"84","author":"Ravasi","year":"2004","journal-title":"Genomics"},{"key":"2023032913020556900_jlb0577-cit-B2","doi-asserted-by":"crossref","first-page":"13035","DOI":"10.1074\/jbc.M710388200","article-title":"Mast cell and monocyte recruitment by S100A12 and its hinge domain","volume":"283","author":"Yan","year":"2008","journal-title":"J. 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