{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:42:39Z","timestamp":1791308559106,"version":"4.3.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2009,8,11]],"date-time":"2009-08-11T00:00:00Z","timestamp":1249948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A novel role for Liver X receptors in lymphocytic cells is described with potential application in immunosuppression and anti-leukemia therapy.<\/jats:p>\n               <jats:p>Liver X receptors (LXRs) are nuclear receptors regulating lipid and cholesterol metabolism. Recent data indicate an additional role of LXR in immunity by controlling dendritic cell and T-cell function and in breast and prostate cancer cells. Here, we show that LXR activation interferes with IL-2 and IL-7-induced proliferation and cell cycle progression of human T-cell blasts mainly through inhibited phosphorylation of the retinoblastoma protein and decreased expression of the cell cycle protein cyclin B. Comparable results were obtained with IL-2-dependent chronic lymphoblastic leukemia (CLL) T cells. Furthermore, we show for B-CLL cells that LXR are functionally active and inhibit expression of survival genes bcl-2 and MMP-9, and significantly reduce cell viability, suggesting an interference of LXR with cytokine-dependent CLL cell survival. In conclusion, our data reveal LXR as a potent modulator of cytokine-dependent proliferation and survival of normal and malignant T and B lymphocytes. This novel LXR action could find clinical application in immunosuppressive and antileukemic therapies.<\/jats:p>","DOI":"10.1189\/jlb.1008663","type":"journal-article","created":{"date-parts":[[2009,8,12]],"date-time":"2009-08-12T04:24:58Z","timestamp":1250051098000},"page":"1039-1048","source":"Crossref","is-referenced-by-count":59,"title":["Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes"],"prefix":"10.1093","volume":"86","author":[{"given":"Ren\u00e9","family":"Geyeregger","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine III, Clinical Divisions of Endocrinology and Metabolism, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medhat","family":"Shehata","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine I, Clinical Divisions of Hematology and Hemostaseology, Medical University of Vienna , Vienna, Austria"},{"name":"Departments of Karl Landsteiner Institute for Cytokine and Tumor Microenvironment, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Zeyda","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine III, Clinical Divisions of Endocrinology and Metabolism, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian W","family":"Kiefer","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine III, Clinical Divisions of Endocrinology and Metabolism, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl M","family":"Stuhlmeier","sequence":"additional","affiliation":[{"name":"Departments of Ludwig Boltzmann Institute for Rheumatology , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edit","family":"Porpaczy","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine I, Clinical Divisions of Hematology and Hemostaseology, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard J","family":"Zlabinger","sequence":"additional","affiliation":[{"name":"Departments of Institute of Immunology, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine I, Clinical Divisions of Hematology and Hemostaseology, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M","family":"Stulnig","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine III, Clinical Divisions of Endocrinology and Metabolism, Medical University of Vienna , Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,8,11]]},"reference":[{"key":"2023032912531441100_jlb1039-cit-b1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/nm1102-1243","article-title":"The liver X receptor gene team: potential new players in atherosclerosis","volume":"8","author":"Repa","year":"2002","journal-title":"Nat. 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