{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:28:54Z","timestamp":1791872934789,"version":"4.3.4"},"reference-count":156,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This review presents evidence that dual targeting of CCR2 and CCR5 has greater therapeutic potential than targeting either receptor alone.<\/jats:p>\n               <jats:p>A cardinal feature of inflammation is the tissue recruitment of leukocytes, a process that is mediated predominantly by chemokines via their receptors on migrating cells. CCR2 and CCR5, two CC chemokine receptors, are important players in the trafficking of monocytes\/macrophages and in the functions of other cell types relevant to disease pathogenesis. This review provides a brief overview of the biological actions of CCR2 and CCR5 and a comprehensive summary of published data that demonstrate the involvement of both receptors in the pathogenesis of immunologic diseases (RA, CD, and transplant rejection) and cardiovascular diseases (atherosclerosis and AIH). In light of the potential for functional redundancy of chemokine receptors in mediating leukocyte trafficking and the consequent concern over insufficient efficacy offered by pharmacologically inhibiting one receptor, this review presents evidence supporting dual targeting of CCR2 and CCR5 as a more efficacious strategy than targeting either receptor alone. It also examines potential safety issues associated with such dual targeting.<\/jats:p>","DOI":"10.1189\/jlb.1009671","type":"journal-article","created":{"date-parts":[[2010,4,2]],"date-time":"2010-04-02T02:04:17Z","timestamp":1270173857000},"page":"41-55","source":"Crossref","is-referenced-by-count":91,"title":["Dual targeting of CCR2 and CCR5: therapeutic potential for immunologic and cardiovascular diseases"],"prefix":"10.1093","volume":"88","author":[{"given":"Qihong","family":"Zhao","sequence":"first","affiliation":[{"name":"Research and Development, Bristol-Myers Squibb , Princeton, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,4,1]]},"reference":[{"key":"2023033005105916200_cit1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1124\/pr.54.2.227","article-title":"International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature","volume":"54","author":"Murphy","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"2023033005105916200_cit2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/84209","article-title":"Chemokines and disease","volume":"2","author":"Gerard","year":"2001","journal-title":"Nat. Immunol."},{"key":"2023033005105916200_cit3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMra052723","article-title":"The many roles of chemokines and chemokine receptors in inflammation","volume":"354","author":"Charo","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"2023033005105916200_cit4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.pharmtox.48.121806.154841","article-title":"Chemokines and their receptors: drug targets in immunity and inflammation","volume":"48","author":"Viola","year":"2008","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"2023033005105916200_cit5","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1126\/science.273.5283.1856","article-title":"Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study","volume":"273","author":"Dean","year":"1996","journal-title":"Science"},{"key":"2023033005105916200_cit6","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/nm1196-1240","article-title":"The role of a mutant CCR5 allele in HIV-1 transmission and disease progression","volume":"2","author":"Huang","year":"1996","journal-title":"Nat. Med."},{"key":"2023033005105916200_cit7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0092-8674(00)80110-5","article-title":"Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection","volume":"86","author":"Liu","year":"1996","journal-title":"Cell"},{"key":"2023033005105916200_cit8","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/382722a0","article-title":"Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene","volume":"382","author":"Samson","year":"1996","journal-title":"Nature"},{"key":"2023033005105916200_cit9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF03401665","article-title":"Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk","volume":"3","author":"Zimmerman","year":"1997","journal-title":"Mol. Med."},{"key":"2023033005105916200_cit10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1056\/NEJM197608052950602","article-title":"The resistance factor to Plasmodium vivax in blacks. The Duffy-blood-group genotype, FyFy","volume":"295","author":"Miller","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"2023033005105916200_cit11","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/ng0695-224","article-title":"Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals","volume":"10","author":"Tournamille","year":"1995","journal-title":"Nat. Genet."},{"key":"2023033005105916200_cit12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1517\/13543770802641346","article-title":"Chemokine receptor antagonists: part 1","volume":"19","author":"Pease","year":"2009","journal-title":"Expert Opin. Ther. Pat."},{"key":"2023033005105916200_cit13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1517\/13543770802641353","article-title":"Chemokine receptor antagonists: part 2","volume":"19","author":"Pease","year":"2009","journal-title":"Expert Opin. Ther. Pat."},{"key":"2023033005105916200_cit14","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1592\/phco.29.3.295","article-title":"Maraviroc, a CCR5 coreceptor antagonist that blocks entry of human immunodeficiency virus type 1","volume":"29","author":"Hunt","year":"2009","journal-title":"Pharmacotherapy"},{"key":"2023033005105916200_cit15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2165\/00003495-200969030-00007","article-title":"Plerixafor: in patients with non-Hodgkin's lymphoma or multiple myeloma","volume":"69","author":"Wagstaff","year":"2009","journal-title":"Drugs"},{"key":"2023033005105916200_cit16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/mic.10.3-4.259.264","article-title":"Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarization","volume":"10","author":"Charo","year":"2003","journal-title":"Microcirculation"},{"key":"2023033005105916200_cit17","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1517\/13543776.16.8.1051","article-title":"CCR5 antagonists: the answer to inflammatory disease?","volume":"16","author":"Ness","year":"2006","journal-title":"Expert Opin. Ther. Pat."},{"key":"2023033005105916200_cit18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","article-title":"Blood monocytes consist of two principal subsets with distinct migratory properties","volume":"19","author":"Geissmann","year":"2003","journal-title":"Immunity"},{"key":"2023033005105916200_cit19","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.4049\/jimmunol.159.4.1993","article-title":"Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines","volume":"159","author":"Sozzani","year":"1997","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit20","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1084\/jem.184.2.569","article-title":"Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes","volume":"184","author":"Loetscher","year":"1996","journal-title":"J. Exp. Med."},{"key":"2023033005105916200_cit21","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1172\/JCI119798","article-title":"Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice","volume":"100","author":"Boring","year":"1997","journal-title":"J. Clin. Invest."},{"key":"2023033005105916200_cit22","doi-asserted-by":"crossref","first-page":"12053","DOI":"10.1073\/pnas.94.22.12053","article-title":"Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2","volume":"94","author":"Kuziel","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033005105916200_cit23","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1084\/jem.186.10.1757","article-title":"Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor","volume":"186","author":"Kurihara","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023033005105916200_cit24","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.187.4.601","article-title":"Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice","volume":"187","author":"Lu","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023033005105916200_cit25","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.4049\/jimmunol.166.7.4697","article-title":"Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice","volume":"166","author":"Mack","year":"2001","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit26","doi-asserted-by":"crossref","first-page":"5370","DOI":"10.4049\/jimmunol.175.8.5370","article-title":"Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344","volume":"175","author":"Brodmerkel","year":"2005","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit27","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1172\/JCI119798","article-title":"Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice","volume":"100","author":"Boring","year":"1997","journal-title":"J. Clin. Invest."},{"key":"2023033005105916200_cit28","doi-asserted-by":"crossref","first-page":"12053","DOI":"10.1073\/pnas.94.22.12053","article-title":"Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2","volume":"94","author":"Kuziel","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033005105916200_cit29","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1084\/jem.186.10.1757","article-title":"Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor","volume":"186","author":"Kurihara","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023033005105916200_cit30","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.187.4.601","article-title":"Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice","volume":"187","author":"Lu","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023033005105916200_cit31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1074-7613(03)00171-7","article-title":"TNF\/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection","volume":"19","author":"Serbina","year":"2003","journal-title":"Immunity"},{"key":"2023033005105916200_cit32","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat. Immunol."},{"key":"2023033005105916200_cit33","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1172\/JCI119798","article-title":"Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice","volume":"100","author":"Boring","year":"1997","journal-title":"J. Clin. Invest."},{"key":"2023033005105916200_cit34","doi-asserted-by":"crossref","first-page":"12053","DOI":"10.1073\/pnas.94.22.12053","article-title":"Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2","volume":"94","author":"Kuziel","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033005105916200_cit35","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1084\/jem.186.10.1757","article-title":"Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor","volume":"186","author":"Kurihara","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023033005105916200_cit36","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.187.4.601","article-title":"Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice","volume":"187","author":"Lu","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023033005105916200_cit37","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1172\/JCI12877","article-title":"The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium","volume":"108","author":"Huo","year":"2001","journal-title":"J. Clin. Invest."},{"key":"2023033005105916200_cit38","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1084\/jem.185.9.1681","article-title":"CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro","volume":"185","author":"Wu","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023033005105916200_cit39","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.exphem.2004.11.015","article-title":"MIP-1\u03b1 utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells","volume":"33","author":"Oba","year":"2005","journal-title":"Exp. Hematol."},{"key":"2023033005105916200_cit40","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1074\/jbc.275.8.5466","article-title":"Human vascular smooth muscle cells possess functional CCR5","volume":"275","author":"Schecter","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2023033005105916200_cit41","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/nm1303","article-title":"CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection","volume":"11","author":"Tyner","year":"2005","journal-title":"Nat. Med."},{"key":"2023033005105916200_cit42","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1002\/1529-0131(200105)44:5<1022::AID-ANR181>3.0.CO;2-N","article-title":"Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes\/macrophages in rheumatoid arthritis","volume":"44","author":"Katschke","year":"2001","journal-title":"Arthritis Rheum."},{"key":"2023033005105916200_cit43","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1189\/jlb.0305130","article-title":"Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis","volume":"79","author":"Crane","year":"2006","journal-title":"J. Leukoc. Biol."},{"key":"2023033005105916200_cit44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1084\/jem.186.1.131","article-title":"An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model","volume":"186","author":"Gong","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023033005105916200_cit45","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.4049\/jimmunol.0900523","article-title":"An engineered GM-CSF-CCL2 fusokine is a potent inhibitor of CCR2-driven inflammation as demonstrated in a murine model of inflammatory arthritis","volume":"183","author":"Rafei","year":"2009","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit46","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1172\/JCI9109","article-title":"C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritis","volume":"106","author":"Youssef","year":"2000","journal-title":"J. Clin. Invest."},{"key":"2023033005105916200_cit47","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/(SICI)1096-9896(199705)182:1<106::AID-PATH816>3.0.CO;2-A","article-title":"The role of monocyte chemoattractant protein-1 (MCP-1) in the pathogenesis of collagen-induced arthritis in rats","volume":"182","author":"Ogata","year":"1997","journal-title":"J. Pathol."},{"key":"2023033005105916200_cit48","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.4049\/jimmunol.160.3.1466","article-title":"Streptococcal cell wall-induced arthritis: requirements for IL-4, IL-10, IFN-\u03b3, and monocyte chemoattractant protein-1","volume":"160","author":"Schimmer","year":"1998","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit49","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/jlb.63.3.359","article-title":"Role of chemokines and cytokines in a reactivation model of arthritis in rats induced by injection with streptococcal cell walls","volume":"63","author":"Schrier","year":"1998","journal-title":"J. Leukoc. Biol."},{"key":"2023033005105916200_cit50","first-page":"973","article-title":"Production and regulation of monocyte chemoattractant protein-1 in lipopolysaccharide- or monosodium urate crystal-induced arthritis in rabbits: roles of tumor necrosis factor \u03b1, interleukin-1, and interleukin-8","volume":"78","author":"Matsukawa","year":"1998","journal-title":"Lab. Invest."},{"key":"2023033005105916200_cit51","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.4049\/jimmunol.180.5.3447","article-title":"Inhibition of monocyte chemoattractant protein-1 ameliorates rat adjuvant-induced arthritis","volume":"180","author":"Shahrara","year":"2008","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit52","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1002\/art.22854","article-title":"Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis","volume":"56","author":"Br\u00fchl","year":"2007","journal-title":"Arthritis Rheum."},{"key":"2023033005105916200_cit53","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.4049\/jimmunol.164.12.6303","article-title":"Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte associated Th2-type immune response in the intestine","volume":"164","author":"Andres","year":"2000","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit54","doi-asserted-by":"crossref","first-page":"G803","DOI":"10.1152\/ajpgi.00069.2006","article-title":"Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells","volume":"291","author":"Khan","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2023033005105916200_cit55","doi-asserted-by":"crossref","first-page":"767","DOI":"10.4049\/jimmunol.172.2.767","article-title":"Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine\/chemokine receptor function in vivo","volume":"172","author":"Abdi","year":"2004","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit56","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.4049\/jimmunol.171.12.6929","article-title":"Blocking the monocyte chemoattractant protein-1\/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism","volume":"171","author":"Lee","year":"2003","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit57","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1161\/01.ATV.0000141045.49616.6f","article-title":"Antimonocyte chemoattractant protein-1 gene therapy attenuates graft vasculopathy","volume":"24","author":"Saiura","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit58","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1159\/000129688","article-title":"Inhibition of MCP-1\/CCR2 signaling does not inhibit intimal proliferation in a mouse aortic transplant model","volume":"45","author":"Alexis","year":"2008","journal-title":"J. Vasc. Res."},{"key":"2023033005105916200_cit59","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.tcm.2005.05.003","article-title":"Local cytokine environments drive aneurysm formation in allografted aortas","volume":"15","author":"Shimizu","year":"2005","journal-title":"Trends Cardiovasc. Med."},{"key":"2023033005105916200_cit60","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1172\/JCI200112214","article-title":"Critical role for the chemokine MCP-1\/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome","volume":"108","author":"Belperio","year":"2001","journal-title":"J. Clin. Invest."},{"key":"2023033005105916200_cit61","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/29788","article-title":"Decreased lesion formation in CCR2-\/- mice reveals a role for chemokines in the initiation of atherosclerosis","volume":"394","author":"Boring","year":"1998","journal-title":"Nature"},{"key":"2023033005105916200_cit62","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0021-9150(98)00318-9","article-title":"Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice","volume":"143","author":"Dawson","year":"1999","journal-title":"Atherosclerosis"},{"key":"2023033005105916200_cit63","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1161\/CIRCULATIONAHA.104.520718","article-title":"Differential influence of chemokine receptors CCR2 and CXCR3 in development of atherosclerosis in vivo","volume":"112","author":"Veillard","year":"2005","journal-title":"Circulation"},{"key":"2023033005105916200_cit64","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1097-2765(00)80139-2","article-title":"Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice","volume":"2","author":"Gu","year":"1998","journal-title":"Mol. Cell"},{"key":"2023033005105916200_cit65","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1172\/JCI5624","article-title":"MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B","volume":"103","author":"Gosling","year":"1999","journal-title":"J. Clin. Invest."},{"key":"2023033005105916200_cit66","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1161\/01.CIR.103.16.2096","article-title":"New anti-monocyte chemoattractant protein-1 gene therapy attenuates atherosclerosis in apolipoprotein E-knockout mice","volume":"103","author":"Ni","year":"2001","journal-title":"Circulation"},{"key":"2023033005105916200_cit67","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1161\/01.CIR.0000038140.80105.AD","article-title":"Anti-monocyte chemoattractant protein-1 gene therapy limits progression and destabilization of established atherosclerosis in apolipoprotein E-knockout mice","volume":"106","author":"Inoue","year":"2002","journal-title":"Circulation"},{"key":"2023033005105916200_cit68","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1161\/01.ATV.0000118275.60121.2b","article-title":"Monocyte chemoattractant protein-1 is an essential inflammatory mediator in angiotensin II-induced progression of established atherosclerosis in hypercholesterolemic mice","volume":"24","author":"Ni","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit69","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1161\/01.ATV.0000019051.88366.9C","article-title":"Propagermanium reduces atherosclerosis in apolipoprotein E knockout mice via inhibition of macrophage infiltration","volume":"22","author":"Yamashita","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit70","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00005344-200302000-00004","article-title":"Long-term treatment with propagermanium suppresses atherosclerosis in WHHL rabbits","volume":"41","author":"Eto","year":"2003","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2023033005105916200_cit71","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/00005344-200303000-00005","article-title":"Propagermanium suppresses macrophage-mediated formation of coronary arteriosclerotic lesions in pigs in vivo","volume":"41","author":"Shimokawa","year":"2003","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"2023033005105916200_cit72","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/hq0402.105720","article-title":"CCR2 deficiency decreases intimal hyperplasia after arterial injury","volume":"22","author":"Roque","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit73","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1161\/01.RES.0000149518.86865.3e","article-title":"Crucial role of the CCL2\/CCR2 axis in neointimal hyperplasia after arterial injury in hyperlipidemic mice involves early monocyte recruitment and CCL2 presentation on platelets","volume":"95","author":"Schober","year":"2004","journal-title":"Circ. Res."},{"key":"2023033005105916200_cit74","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.bbrc.2003.09.088","article-title":"MCP-1 deficiency is associated with reduced intimal hyperplasia after arterial injury","volume":"310","author":"Kim","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2023033005105916200_cit75","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jvs.2009.03.027","article-title":"Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice","volume":"50","author":"Eefting","year":"2009","journal-title":"J. Vasc. Surg."},{"key":"2023033005105916200_cit76","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1161\/01.RES.0000020561.03244.7E","article-title":"Importance of monocyte chemoattractant protein-1 pathway in neointimal hyperplasia after periarterial injury in mice and monkeys","volume":"90","author":"Egashira","year":"2002","journal-title":"Circ. Res."},{"key":"2023033005105916200_cit77","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1161\/01.ATV.0000235694.69719.e2","article-title":"Anti-MCP-1 gene therapy inhibits vascular smooth muscle cells proliferation and attenuates vein graft thickening both in vitro and in vivo","volume":"26","author":"Schepers","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit78","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1161\/01.RES.84.3.306","article-title":"Anti-monocyte chemoattractant protein-1\/monocyte chemotactic and activating factor antibody inhibits neointimal hyperplasia in injured rat carotid arteries","volume":"84","author":"Furukawa","year":"1999","journal-title":"Circ. Res."},{"key":"2023033005105916200_cit79","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1096\/fj.02-0094fje","article-title":"Anti-monocyte chemoattractant protein-1 gene therapy inhibits restenotic changes (neointimal hyperplasia) after balloon injury in rats and monkeys","volume":"16","author":"Usui","year":"2002","journal-title":"FASEB J."},{"key":"2023033005105916200_cit80","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1161\/01.CIR.0000018603.67989.71","article-title":"Essential role of monocyte chemoattractant protein-1 in development of restenotic changes (neointimal hyperplasia and constrictive remodeling) after balloon angioplasty in hypercholesterolemic rabbits","volume":"105","author":"Mori","year":"2002","journal-title":"Circulation"},{"key":"2023033005105916200_cit81","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/sj.gt.3302288","article-title":"Antimonocyte chemoattractant protein-1 gene therapy reduces experimental in-stent restenosis in hypercholesterolemic rabbits and monkeys","volume":"11","author":"Ohtani","year":"2004","journal-title":"Gene Ther."},{"key":"2023033005105916200_cit82","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1161\/ATVBAHA.107.154609","article-title":"Local delivery of anti-monocyte chemoattractant protein-1 by gene-eluting stents attenuates in-stent stenosis in rabbits and monkeys","volume":"27","author":"Egashira","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit83","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.jvs.2007.01.066","article-title":"Blockade of monocyte chemoattractant protein-1 by adenoviral gene transfer inhibits experimental vein graft neointimal formation","volume":"45","author":"Tatewaki","year":"2007","journal-title":"J. Vasc. Surg."},{"key":"2023033005105916200_cit84","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/hh0402.105956","article-title":"Targeting CCR2 or CD18 inhibits experimental in-stent restenosis in primates: inhibitory potential depends on type of injury and leukocytes targeted","volume":"90","author":"Horvath","year":"2002","journal-title":"Circ. Res."},{"key":"2023033005105916200_cit85","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.atherosclerosis.2006.10.029","article-title":"Catheter-based adenovirus-mediated anti-monocyte chemoattractant gene therapy attenuates in-stent neointima formation in cynomolgus monkeys","volume":"194","author":"Nakano","year":"2007","journal-title":"Atherosclerosis"},{"key":"2023033005105916200_cit86","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1172\/JCI200420126","article-title":"Experimental arthritis in CC chemokine receptor 2-null mice closely mimics severe human rheumatoid arthritis","volume":"113","author":"Quinones","year":"2004","journal-title":"J. Clin. Invest."},{"key":"2023033005105916200_cit87","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00109-006-0039-3","article-title":"CC chemokine receptor (CCR)-2 prevents arthritis development following infection by Mycobacterium avium","volume":"84","author":"Quinones","year":"2006","journal-title":"J. Mol. Med."},{"key":"2023033005105916200_cit88","doi-asserted-by":"crossref","first-page":"890","DOI":"10.4049\/jimmunol.172.2.890","article-title":"Dual role of CCR2 during initiation and progression of collagen-induced arthritis: evidence for regulatory activity of CCR2+ T cells","volume":"172","author":"Br\u00fchl","year":"2004","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit89","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1002\/art.21975","article-title":"A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis","volume":"54","author":"Haringman","year":"2006","journal-title":"Arthritis Rheum."},{"key":"2023033005105916200_cit90","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1002\/art.23591","article-title":"Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trial","volume":"58","author":"Vergunst","year":"2008","journal-title":"Arthritis Rheum."},{"key":"2023033005105916200_cit91","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cyto.2005.03.003","article-title":"Decreased IgG production but increased MIP-1\u03b2 expression in collagen-induced arthritis in C-C chemokine receptor 5-deficient mice","volume":"31","author":"Bao","year":"2005","journal-title":"Cytokine"},{"key":"2023033005105916200_cit92","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/art.20850","article-title":"Inhibition of the development of collagen-induced arthritis in rhesus monkeys by a small molecular weight antagonist of CCR5","volume":"52","author":"Vierboom","year":"2005","journal-title":"Arthritis Rheum."},{"key":"2023033005105916200_cit93","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/382722a0","article-title":"Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene","volume":"382","author":"Samson","year":"1996","journal-title":"Nature"},{"key":"2023033005105916200_cit94","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0092-8674(00)80110-5","article-title":"Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection","volume":"86","author":"Liu","year":"1996","journal-title":"Cell"},{"key":"2023033005105916200_cit95","first-page":"1462","article-title":"CC chemokine receptor 5 polymorphism in rheumatoid arthritis","volume":"25","author":"Garred","year":"1998","journal-title":"J. Rheumatol."},{"key":"2023033005105916200_cit96","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/1529-0131(199905)42:5<989::AID-ANR18>3.0.CO;2-U","article-title":"Association of rheumatoid arthritis with a functional chemokine receptor, CCR5","volume":"42","author":"G\u00f3mez-Reino","year":"1999","journal-title":"Arthritis Rheum."},{"key":"2023033005105916200_cit97","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/ard.2004.023333","article-title":"Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritis","volume":"64","author":"Pokorny","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"2023033005105916200_cit98","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/sj.gene.6363673","article-title":"CCR5 (chemokine receptor-5) DNA-polymorphism influences the severity of rheumatoid arthritis","volume":"1","author":"Zapico","year":"2000","journal-title":"Genes Immun."},{"key":"2023033005105916200_cit99","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/1529-0131(199806)41:6<1135::AID-ART24>3.0.CO;2-N","article-title":"The \u039432 deletion of CCR5 receptor in rheumatoid arthritis","volume":"41","author":"Cooke","year":"1998","journal-title":"Arthritis Rheum."},{"key":"2023033005105916200_cit100","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/sj.gene.6364298","article-title":"Negative association between the chemokine receptor CCR5-\u039432 polymorphism and rheumatoid arthritis: a meta-analysis","volume":"7","author":"Prahalad","year":"2006","journal-title":"Genes Immun."},{"key":"2023033005105916200_cit101","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/sj.gene.6364317","article-title":"Association of two functional polymorphisms in the CCR5 gene with juvenile rheumatoid arthritis","volume":"7","author":"Prahalad","year":"2006","journal-title":"Genes Immun."},{"key":"2023033005105916200_cit102","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1002\/1521-4141(200208)32:8<2124::AID-IMMU2124>3.0.CO;2-S","article-title":"A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses","volume":"32","author":"Yang","year":"2002","journal-title":"Eur. J. Immunol."},{"key":"2023033005105916200_cit103","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1189\/jlb.0602269","article-title":"The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3","volume":"73","author":"Gao","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"2023033005105916200_cit104","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1093\/intimm\/dxh284","article-title":"The simultaneous blockade of chemokine receptors CCR2, CCR5 and CXCR3 by a non-peptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis","volume":"17","author":"Tokuyama","year":"2005","journal-title":"Int. Immunol."},{"key":"2023033005105916200_cit105","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1097\/00007890-200110150-00003","article-title":"Beneficial effects of targeting CCR5 in allograft recipients","volume":"72","author":"Gao","year":"2001","journal-title":"Transplantation"},{"key":"2023033005105916200_cit106","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2249.2009.03982.x","article-title":"CCR5 blockade in combination with rapamycin prolongs cardiac allograft survival in mice","volume":"157","author":"Li","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"2023033005105916200_cit107","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.4049\/jimmunol.174.10.6499","article-title":"Absence of recipient CCR5 promotes early and increased allospecific antibody responses to cardiac allografts","volume":"174","author":"Amano","year":"2005","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit108","doi-asserted-by":"crossref","first-page":"5238","DOI":"10.4049\/jimmunol.179.8.5238","article-title":"Antibody-mediated rejection of cardiac allografts in CCR5-deficient recipients","volume":"179","author":"Nozaki","year":"2007","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit109","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.2337\/diabetes.51.8.2489","article-title":"The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection","volume":"51","author":"Abdi","year":"2002","journal-title":"Diabetes"},{"key":"2023033005105916200_cit110","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.transproceed.2006.10.193","article-title":"Blocking the CC chemokine receptor 5 pathway by antisense peptide nucleic acid prolongs islet allograft survival","volume":"39","author":"Yang","year":"2007","journal-title":"Transplant. Proc."},{"key":"2023033005105916200_cit111","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.4049\/jimmunol.179.4.2289","article-title":"CCR5 blockade modulates inflammation and alloimmunity in primates","volume":"179","author":"Schr\u00f6der","year":"2007","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit112","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.4049\/jimmunol.180.7.4714","article-title":"Combined CXCR3\/CCR5 blockade attenuates acute and chronic rejection","volume":"180","author":"Schnickel","year":"2008","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit113","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1161\/01.CIR.0000112595.65972.8A","article-title":"Combined blockade of the chemokine receptors CCR1 and CCR5 attenuates chronic rejection","volume":"109","author":"Yun","year":"2004","journal-title":"Circulation"},{"key":"2023033005105916200_cit114","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/S0140-6736(00)04898-4","article-title":"CC chemokine receptor 5 and renal-transplant survival","volume":"357","author":"Fischereder","year":"2001","journal-title":"Lancet"},{"key":"2023033005105916200_cit115","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1161\/01.ATV.0000253886.44609.ae","article-title":"CCR5 but not CCR1 deficiency reduces development of diet-induced atherosclerosis in mice","volume":"27","author":"Braunersreuther","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit116","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1016\/j.atherosclerosis.2007.03.026","article-title":"CC chemokine receptor 5 influences late-stage atherosclerosis","volume":"195","author":"Quinones","year":"2007","journal-title":"Atherosclerosis"},{"key":"2023033005105916200_cit117","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1161\/01.RES.0000109793.17591.4E","article-title":"Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice","volume":"94","author":"Veillard","year":"2004","journal-title":"Circ. Res."},{"key":"2023033005105916200_cit118","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1161\/ATVBAHA.108.165423","article-title":"A novel RANTES antagonist prevents progression of established atherosclerotic lesions in mice","volume":"28","author":"Braunersreuther","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit119","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1182\/blood-2005-09-3922","article-title":"Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10","volume":"107","author":"Zernecke","year":"2006","journal-title":"Blood"},{"key":"2023033005105916200_cit120","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1161\/CIRCULATIONAHA.107.708016","article-title":"Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice","volume":"116","author":"Krohn","year":"2007","journal-title":"Circulation"},{"key":"2023033005105916200_cit121","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1161\/01.CIR.0000028590.02477.6F","article-title":"Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury","volume":"106","author":"Schober","year":"2002","journal-title":"Circulation"},{"key":"2023033005105916200_cit122","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0014-4800(03)00093-5","article-title":"The role of the \u03b2 chemokines in experimental obliterative bronchiolitis","volume":"75","author":"Farivar","year":"2003","journal-title":"Exp. Mol. Pathol."},{"key":"2023033005105916200_cit123","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/01.tp.0000166338.99933.e1","article-title":"A novel small-molecule compound targeting CCR5 and CXCR3 prevents acute and chronic allograft rejection","volume":"80","author":"Akashi","year":"2005","journal-title":"Transplantation"},{"key":"2023033005105916200_cit124","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1097\/01.ASN.0000130622.48066.D9","article-title":"Differential expression of chemokines and chemokine receptors in murine islet allografts: the role of CCR2 and CCR5 signaling pathways","volume":"15","author":"Schr\u00f6ppel","year":"2004","journal-title":"J. Am. Soc. Nephrol."},{"key":"2023033005105916200_cit125","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1161\/01.ATV.19.6.1518","article-title":"Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice","volume":"19","author":"Aiello","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit126","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1089\/107999001750277862","article-title":"An anti-inflammatory drug, propagermanium, may target GPI-anchored proteins associated with an MCP-1 receptor, CCR2","volume":"21","author":"Yokochi","year":"2001","journal-title":"J. Interferon Cytokine Res."},{"key":"2023033005105916200_cit127","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/01.ATV.0000163181.40896.42","article-title":"Repopulation of apolipoprotein E knockout mice with CCR2-deficient bone marrow progenitor cells does not inhibit ongoing atherosclerotic lesion development","volume":"25","author":"Guo","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit128","doi-asserted-by":"crossref","first-page":"II","DOI":"10.1161\/circ.116.suppl_16.II_171","article-title":"Abstract 874. MLN1202, a novel CCR2 antagonist, decreases C-reactive protein in patients at risk for atherosclerotic cardiovascular disease in a double blind placebo controlled study","volume":"116","author":"Davidson","year":"2007","journal-title":"Circulation"},{"key":"2023033005105916200_cit129","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0021-9150(02)00382-9","article-title":"CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice","volume":"167","author":"Kuziel","year":"2003","journal-title":"Atherosclerosis"},{"key":"2023033005105916200_cit130","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1172\/JCI16790","article-title":"Chemokine receptor mutant CX3CR1\u2013M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans","volume":"111","author":"McDermott","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2023033005105916200_cit131","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.4049\/jimmunol.171.10.5498","article-title":"Inhibition of airway inflammation by amino-terminally modified RANTES\/CC chemokine ligand 5 analogues is not mediated through CCR3","volume":"171","author":"Chvatchko","year":"2003","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit132","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2119\/2005-00028.Potteaux","article-title":"Chemokine receptor CCR1 disruption in bone marrow cells enhances atherosclerotic lesion development and inflammation in mice","volume":"11","author":"Potteaux","year":"2005","journal-title":"Mol. Med."},{"key":"2023033005105916200_cit133","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1161\/01.ATV.0000253886.44609.ae","article-title":"Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice","volume":"27","author":"Braunersreuther","year":"2007","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit134","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1161\/01.ATV.0000231527.22762.71","article-title":"Role of bone marrow-derived CC-chemokine receptor 5 in the development of atherosclerosis of low-density lipoprotein receptor knockout mice","volume":"26","author":"Potteaux","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit135","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1161\/01.ATV.0000192018.90021.c0","article-title":"HIV entry inhibitor TAK-779 attenuates atherogenesis in low-density lipoprotein receptor-deficient mice","volume":"25","author":"van Wanrooij","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit136","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1161\/CIRCULATIONAHA.107.745091","article-title":"Combined inhibition of CCL2, CX3CR1, and CCR5 abrogates Ly6C(hi) and Ly6C(lo) monocytosis and almost abolishes atherosclerosis in hypercholesterolemic mice","volume":"117","author":"Combadi\u00e8re","year":"2008","journal-title":"Circulation"},{"key":"2023033005105916200_cit137","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1172\/JCI28549","article-title":"Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques","volume":"117","author":"Tacke","year":"2007","journal-title":"J. Clin. Invest."},{"key":"2023033005105916200_cit138","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/01.CIR.0000057548.68243.42","article-title":"Decreased atherosclerotic lesion formation in CX3CR1\/apolipoprotein E double knockout mice","volume":"107","author":"Combadi\u00e8re","year":"2003","journal-title":"Circulation"},{"key":"2023033005105916200_cit139","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1172\/JCI15555","article-title":"Decreased atherosclerosis in CX3CR1-\/- mice reveals a role for fractalkine in atherogenesis","volume":"111","author":"Lesnik","year":"2003","journal-title":"J. Clin. Invest."},{"key":"2023033005105916200_cit140","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1161\/ATVBAHA.108.180505","article-title":"Regulation of the migration and survival of monocyte subsets by chemokine receptors and its relevance to atherosclerosis","volume":"29","author":"Gautier","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2023033005105916200_cit141","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1182\/blood.V94.3.875.415k28_875_883","article-title":"Loss of CCR2 expression and functional response to monocyte chemotactic protein (MCP-1) during the differentiation of human monocytes: role of secreted MCP-1 in the regulation of the chemotactic response","volume":"194","author":"Fantuzzi","year":"1999","journal-title":"Blood"},{"key":"2023033005105916200_cit142","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1189\/jlb.69.2.248","article-title":"Increase of CCR1 and CCR5 expression and enhanced functional response to MIP-1 \u03b1 during differentiation of human monocytes to macrophages","volume":"69","author":"Kaufmann","year":"2001","journal-title":"J. Leukoc. Biol."},{"key":"2023033005105916200_cit143","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1002\/1529-0131(200105)44:5<1022::AID-ANR181>3.0.CO;2-N","article-title":"Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes\/macrophages in rheumatoid arthritis","volume":"44","author":"Katschke","year":"2001","journal-title":"Arthritis Rheum."},{"key":"2023033005105916200_cit144","doi-asserted-by":"crossref","first-page":"17161","DOI":"10.1074\/jbc.271.29.17161","article-title":"Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1\u03b2, and MIP-1\u03b1","volume":"271","author":"Raport","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2023033005105916200_cit145","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.immunol.17.1.657","article-title":"Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease","volume":"17","author":"Berger","year":"1999","journal-title":"Annu. Rev. Immunol."},{"key":"2023033005105916200_cit146","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1084\/jem.20042530","article-title":"Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection","volume":"202","author":"Glass","year":"2005","journal-title":"J. Exp. Med."},{"key":"2023033005105916200_cit147","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20051970","article-title":"CCR5 deficiency increases risk of symptomatic West Nile virus infection","volume":"203","author":"Glass","year":"2006","journal-title":"J. Exp. Med."},{"key":"2023033005105916200_cit148","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1086\/524691","article-title":"Genetic deficiency of chemokine receptor CCR5 is a strong risk factor for symptomatic West Nile virus infection: a meta-analysis of 4 cohorts in the US epidemic","volume":"197","author":"Lim","year":"2008","journal-title":"J. Infect. Dis."},{"key":"2023033005105916200_cit149","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1086\/524709","article-title":"A deletion in the chemokine receptor 5 (CCR5) gene is associated with tickborne encephalitis","volume":"197","author":"Kindberg","year":"2008","journal-title":"J. Infect. Dis."},{"key":"2023033005105916200_cit150","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.immunol.26.021607.090326","article-title":"Monocyte-mediated defense against microbial pathogens","volume":"26","author":"Serbina","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"2023033005105916200_cit151","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/COH.0b013e3283223d76","article-title":"Safety concerns about CCR5 as an antiviral target","volume":"4","author":"Telenti","year":"2009","journal-title":"Curr. Opin. HIV AIDS"},{"key":"2023033005105916200_cit152","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1053\/jhep.2002.33162","article-title":"Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouse","volume":"35","author":"Dambach","year":"2002","journal-title":"Hepatology"},{"key":"2023033005105916200_cit153","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.4049\/jimmunol.170.10.5252","article-title":"C-C chemokine ligand 2\/monocyte chemoattractant protein-1 directly inhibits NKT cell IL-4 production and is hepatoprotective in T cell-mediated hepatitis in the mouse","volume":"170","author":"Ajuebor","year":"2003","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit154","doi-asserted-by":"crossref","first-page":"8027","DOI":"10.4049\/jimmunol.174.12.8027","article-title":"Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cells","volume":"174","author":"Ajuebor","year":"2005","journal-title":"J. Immunol."},{"key":"2023033005105916200_cit155","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.2353\/ajpath.2007.060690","article-title":"CCR5 deficiency drives enhanced natural killer cell trafficking to and activation within the liver in murine T cell-mediated hepatitis","volume":"170","author":"Ajuebor","year":"2007","journal-title":"Am. J. Pathol."},{"key":"2023033005105916200_cit156","first-page":"409","article-title":"CCR5 antagonists: comparison of efficacy, side effects, pharmacokinetics and interactions\u2014review of the literature","volume":"12","author":"Emmelkamp","year":"2007","journal-title":"Eur. J. Med. Res."}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1189%2Fjlb.1009671","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/88\/1\/41\/49657281\/jlb0041.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/88\/1\/41\/49657281\/jlb0041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T19:43:59Z","timestamp":1680205439000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/88\/1\/41\/6959835"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,1]]},"references-count":156,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,4,1]]},"published-print":{"date-parts":[[2010,4,1]]}},"URL":"https:\/\/doi.org\/10.1189\/jlb.1009671","relation":{},"ISSN":["1938-3673","0741-5400"],"issn-type":[{"value":"1938-3673","type":"electronic"},{"value":"0741-5400","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,7]]},"published":{"date-parts":[[2010,4,1]]}}}