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Roemmers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The role of CD16\u2013 and CD16+ Mo subsets in human TB remains unknown. Our aim was to characterize Mo subsets from TB patients and to assess whether the inflammatory milieu from TB pleurisy modulate their phenotype and recruitment. We found an expansion of peripheral CD16+ Mo that correlated with disease severity and with TNF-\u03b1 plasma levels. Circulating Mo from TB patients are activated, showing a higher CD14, CD16, and CD11b expression and Mtb binding than HS. Both subsets coexpressed CCR2\/CCR5, showing a potential ability to migrate to the inflammatory site. In tuberculous PF, the CD16+ subset was the main Mo\/M\u03a6 population, accumulation that can be favored by the induction of CD16 expression in CD16\u2013 Mo triggered by soluble factors found in this inflammatory milieu. CD16+ Mo in PF were characterized by a high density of receptors for Mtb recognition (DC-SIGN, MR, CD11b) and for lipid-antigens presentation (CD1b), allowing them to induce a successful, specific T cell proliferation response. Hence, in tuberculous PF, CD16+ Mo constitute the main APC population; whereas in PB, their predominance is associated with the severity of pulmonary TB, suggesting a paradoxical role of the CD16+ Mo subset that depends on the cellular localization.<\/jats:p>","DOI":"10.1189\/jlb.1010577","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T04:23:19Z","timestamp":1301631799000},"page":"69-75","source":"Crossref","is-referenced-by-count":69,"title":["Paradoxical role of CD16+CCR2+CCR5+ monocytes in tuberculosis: efficient APC in pleural effusion but also mark disease severity in blood"],"prefix":"10.1093","volume":"90","author":[{"given":"Luciana","family":"Balboa","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M","family":"Romero","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan I","family":"Basile","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen A","family":"Sabio y Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Schierloh","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noem\u00ed","family":"Yokobori","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Geffner","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M","family":"Musella","sequence":"additional","affiliation":[{"name":"Servicio de Tisioneumonolog\u00eda, Hospital Mu\u00f1iz , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Castagnino","sequence":"additional","affiliation":[{"name":"Servicio de Tisioneumonolog\u00eda, Hospital Mu\u00f1iz , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Abbate","sequence":"additional","affiliation":[{"name":"Servicio de Tisioneumonolog\u00eda, Hospital Mu\u00f1iz , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"de la Barrera","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda C","family":"Sasiain","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Alem\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Hematol\u00f3gicas, Academia Nacional de Medicina , Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,3,31]]},"reference":[{"key":"2023033005001929300_","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1128\/iai.64.3.683-690.1996","article-title":"Immunopathology of tuberculosis: roles of macrophages and monocytes","volume":"64","author":"Fenton","year":"1996","journal-title":"Infect. 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