{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:37:39Z","timestamp":1789447059005,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2013,3,29]],"date-time":"2013-03-29T00:00:00Z","timestamp":1364515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"crossref","award":["R01AI090059"],"award-info":[{"award-number":["R01AI090059"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"crossref","award":["R01ES015050"],"award-info":[{"award-number":["R01ES015050"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"U.S. National Institutes of Health","doi-asserted-by":"crossref","award":["P42ES013648"],"award-info":[{"award-number":["P42ES013648"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>RSV reinfection increases IL-4R\u03b1 expression on T helper cells, responsible for the enhanced immunopathologies in mice initially infected as neonates.<\/jats:p>\n               <jats:p>RSV is the major cause of severe bronchiolitis in infants, and severe bronchiolitis as a result of RSV is associated with subsequent asthma development. A biased Th2 immune response is thought to be responsible for neonatal RSV pathogenesis; however, molecular mechanisms remain elusive. Our data demonstrate, for the first time, that IL-4R\u03b1 is up-regulated in vitro on human CD4+ T cells from cord blood following RSV stimulation and in vivo on mouse pulmonary CD4+ T cells upon reinfection of mice, initially infected as neonates. Th cell-specific deletion of Il4ra attenuated Th2 responses and abolished the immunopathophysiology upon reinfection, including airway hyper-reactivity, eosinophilia, and mucus hyperproduction in mice infected initially as neonates. These findings support a pathogenic role for IL-4R\u03b1 on Th cells following RSV reinfection of mice initially infected as neonates; more importantly, our data from human cells suggest that the same mechanism occurs in humans.<\/jats:p>","DOI":"10.1189\/jlb.1012498","type":"journal-article","created":{"date-parts":[[2013,3,30]],"date-time":"2013-03-30T01:30:41Z","timestamp":1364607041000},"page":"933-942","source":"Crossref","is-referenced-by-count":50,"title":["IL-4R\u03b1 on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates"],"prefix":"10.1093","volume":"93","author":[{"given":"Dahui","family":"You","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center , New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Marr","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of British Columbia and the Child & Family Research Institute , Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordy","family":"Saravia","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center , New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishwas","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center , New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg I","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center , New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart E","family":"Turvey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of British Columbia and the Child & Family Research Institute , Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Brombacher","sequence":"additional","affiliation":[{"name":"Department of International Center for Genetic Engineering and Biotechnology and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town , Western Cape, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De\u2019Broski R","family":"Herbert","sequence":"additional","affiliation":[{"name":"Department of School of Medicine, University of California at San Francisco , San Francisco, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephania A","family":"Cormier","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center , New Orleans, Louisiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,3,29]]},"reference":[{"key":"2023012312533402200_B1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.jaci.2005.07.012","article-title":"Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response","volume":"116","author":"Kristjansson","year":"2005","journal-title":"J Allergy Clin. 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