{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:23:11Z","timestamp":1788870191293,"version":"build-2803163510"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2004,4,23]],"date-time":"2004-04-23T00:00:00Z","timestamp":1082678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["RO1 AI-35285"],"award-info":[{"award-number":["RO1 AI-35285"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,4,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Evidence that \u03b3\/\u03b4 T cells play a broad, immunoregulatory role has been accumulating steadily. We show here that myeloid cells are disregulated after peritoneal infection with Listeria monocytogenes in mice lacking \u03b3\/\u03b4 T cells. Inflammatory populations of neutrophils and monocytes recruited to the site of infection remained longer. Intracellular cytokine analysis showed that frequencies of myeloid cells producing interleukin-12 and tumor necrosis factor \u03b1 were higher and remained elevated longer after infection in mice genetically deficient in \u03b3\/\u03b4 T cells. In vivo dye-tracking studies indicated that the majority of inflammatory monocytes differentiated into resident tissue macrophages in situ. In vitro experiments confirmed that monocytes harvested from mice lacking \u03b3\/\u03b4 T cells were defective in their maturation process. This evidence suggests that \u03b3\/\u03b4 T cells promote differentiation in the monocyte\/macrophage lineage. These cells are important for bactericidal activity, inflammatory cytokine production, clearance of inflammatory neutrophils, and ultimately, antigen presentation to T cells. Regulation of monocyte\/macrophage differentiation may underlie a broad segment of the phenotypic alterations that have been reported in mice lacking \u03b3\/\u03b4 T cells.<\/jats:p>","DOI":"10.1189\/jlb.1103574","type":"journal-article","created":{"date-parts":[[2004,4,26]],"date-time":"2004-04-26T20:53:32Z","timestamp":1083012812000},"page":"104-115","source":"Crossref","is-referenced-by-count":19,"title":["Changes in peritoneal myeloid populations and their proinflammatory cytokine expression during infection with\n                    <i>Listeria monocytogenes<\/i>\n                    are altered in the absence of \u03b3\/\u03b4 T cells"],"prefix":"10.1093","volume":"76","author":[{"given":"Marianne J","family":"Skeen","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly M","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Kirk","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Emory University School of Medicine , Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,4,23]]},"reference":[{"key":"2023033100094747500_","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0065-2776(08)60400-9","article-title":"Immunoregulatory functions of \u03b3\u03b4 T cells","volume":"71","author":"Born","year":"1999","journal-title":"Adv. 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