{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:28:25Z","timestamp":1789522105116,"version":"build-2803163510"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2004,6,14]],"date-time":"2004-06-14T00:00:00Z","timestamp":1087171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001655","name":"German Academic Exchange Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"BMBF","doi-asserted-by":"publisher","award":["0311591"],"award-info":[{"award-number":["0311591"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK43025"],"award-info":[{"award-number":["DK43025"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["CA75192"],"award-info":[{"award-number":["CA75192"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007602","name":"NIH Cancer Center","doi-asserted-by":"publisher","award":["CA08748"],"award-info":[{"award-number":["CA08748"]}],"id":[{"id":"10.13039\/501100007602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007602","name":"NIH Cancer Center","doi-asserted-by":"publisher","award":["CA70388"],"award-info":[{"award-number":["CA70388"]}],"id":[{"id":"10.13039\/501100007602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,6,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recurrent cytogenetic abnormalities in leukemic blasts make these an attractive source for dendritic cells (DC) to induce a leukemia-specific immune response. In this study, three leukemic cell lines were investigated: Kasumi-1 and SKNO-1 (two acute myeloid leukemia (AML) cell lines carrying the (8;21)-chromosomal translocation, resulting in the expression of the leukemia-specific fusion protein AML1-eight-twenty-one) and REH, an acute lymphoblastic leukemia cell line with the (12;21)-chromosomal translocation and expression of translocation ETS-like leukemia-AML1. These fusion proteins are implicated in the pathogenesis of the leukemic state by recruiting corepressors and histone deacetylases (HDAC), which interfere with normal cell differentiation. In vitro generation of DC was achieved using a cytokine cocktail containing tumor necrosis factor \u03b1, granulocyte macrophage-colony stimulating factor, c-kit ligand, and soluble CD40 ligand; yet, addition of the HDAC inhibitor (Hdi) trichostatin A enhanced DC differentiation with retention of the fusion transcripts. These leukemic DC showed high-level CD83 and human leukocyte antigen (HLA)-DR expression and had a high allostimulatory potential. Only DC generated from these cell lines after Hdi induced blast-specific cytotoxic T cell responses in HLA-A-matched T cells with a cytotoxicity of 42% in parental Kasumi-1 and 83% in parental REH cells, respectively. This model system suggests that the Hdi supports the in vitro differentiation of DC from leukemic blasts with AML1-containing fusion proteins.<\/jats:p>","DOI":"10.1189\/jlb.1103581","type":"journal-article","created":{"date-parts":[[2004,6,15]],"date-time":"2004-06-15T18:26:13Z","timestamp":1087323973000},"page":"623-633","source":"Crossref","is-referenced-by-count":19,"title":["Histone deacetylase inhibition improves dendritic cell differentiation of leukemic blasts with AML1-containing fusion proteins"],"prefix":"10.1093","volume":"76","author":[{"given":"Anja","family":"Moldenhauer","sequence":"first","affiliation":[{"name":"Institute for Transfusion Medicine and Immunehaematology, Campus Virchow-Klinikum, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C","family":"Frank","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute , New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Pinilla-Ibarz","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute , New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Holland","sequence":"additional","affiliation":[{"name":"Robert-Koch-Institut , Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piernicola","family":"Boccuni","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute , New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Scheinberg","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute , New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulgabar","family":"Salama","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine and Immunehaematology, Campus Virchow-Klinikum, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Seeger","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Charit\u00e9, Campus Virchow-Klinikum, Humboldt-University Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm A S","family":"Moore","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute , New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D","family":"Nimer","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Institute , New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,6,14]]},"reference":[{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1073\/pnas.96.8.4592","article-title":"A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors","volume":"96","author":"Saito","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/35106079","article-title":"Histone deacetylases and cancer: causes and therapies","volume":"1","author":"Marks","year":"2001","journal-title":"Nat. Rev. Cancer"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"34940","DOI":"10.1074\/jbc.274.49.34940","article-title":"Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects","volume":"274","author":"Sambucetti","year":"1999","journal-title":"J. Biol. Chem."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1182\/blood-2002-08-2675","article-title":"Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Ablpositive human acute leukemia cells","volume":"101","author":"Nimmanapalli","year":"2003","journal-title":"Blood"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/sj.leu.2402776","article-title":"Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1\/ETO-positive leukemic cells","volume":"17","author":"Klisovic","year":"2003","journal-title":"Leukemia"},{"key":"2023033100012384100_","first-page":"2118","article-title":"Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and-resistant Bcr\/Abl+ human myeloid leukemia cells","volume":"63","author":"Yu","year":"2003","journal-title":"Cancer Res."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1182\/blood-2002-02-0567","article-title":"The histone deacetylase inhibitor AN-9 has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines","volume":"100","author":"Batova","year":"2002","journal-title":"Blood"},{"key":"2023033100012384100_","volume-title":"Wintrobe's Clinical Hematology","author":"Lee","year":"1999"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0037-1963(00)90018-0","article-title":"Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia","volume":"37","author":"Ferrando","year":"2000","journal-title":"Semin. Hematol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"7185","DOI":"10.1128\/MCB.18.12.7185","article-title":"Aberrant recruitment of the nuclear receptor corepressorhistone deacetylase complex by the acute myeloid leukemia fusion partner ETO","volume":"18","author":"Gelmetti","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"6470","DOI":"10.1128\/MCB.21.19.6470-6483.2001","article-title":"ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain","volume":"21","author":"Amann","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1038\/sj.onc.1204479","article-title":"TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3","volume":"20","author":"Wang","year":"2001","journal-title":"Oncogene"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1046\/j.1365-2141.1999.01377.x","article-title":"The AML1-ETO chimaeric transcription factor in acute myeloid leukaemia: biology and clinical significance","volume":"106","author":"Downing","year":"1999","journal-title":"Br. J. Haematol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0959-437X(02)00018-7","article-title":"The core-binding factor leukemias: lessons learned from murine models","volume":"13","author":"Downing","year":"2003","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1182\/blood.V99.1.15","article-title":"The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells","volume":"99","author":"Mulloy","year":"2002","journal-title":"Blood"},{"key":"2023033100012384100_","first-page":"2766","article-title":"Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells","volume":"59","author":"Wang","year":"1999","journal-title":"Cancer Res."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"Gottlicher","year":"2001","journal-title":"EMBO J."},{"key":"2023033100012384100_","first-page":"3637","article-title":"The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1\/WAF1 1","volume":"63","author":"Rosato","year":"2003","journal-title":"Cancer Res."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1046\/j.1365-2141.2000.01933.x","article-title":"Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-trans retinoic acid","volume":"108","author":"Kitamura","year":"2000","journal-title":"Br. J. Haematol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1182\/blood.V96.12.3847","article-title":"Up-regulation of costimulatory\/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells","volume":"96","author":"Maeda","year":"2000","journal-title":"Blood"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/sj.leu.2402979","article-title":"Vaccination of chronic myeloid leukemia patients with autologous in vitro cultured leukemic dendritic cells","volume":"17","author":"Ossenkoppele","year":"2003","journal-title":"Leukemia"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1615\/CritRevImmunol.v21.i1-3.100","article-title":"Therapeutic potential of leukemia-derived dendritic cells: preclinical and clinical progress","volume":"21","author":"Claxton","year":"2001","journal-title":"Crit. Rev. Immunol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/sj.leu.2402013","article-title":"Leukemic dendritic cells generated in the presence of FLT3 ligand have the capacity to stimulate an autologous leukemia-specific cytotoxic T cell response from patients with acute myeloid leukemia","volume":"15","author":"Woiciechowsky","year":"2001","journal-title":"Leukemia"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1089\/152581602753658529","article-title":"Comparison of phenotypic and functional dendritic cells derived from human umbilical cord blood and peripheral blood mononuclear cells","volume":"11","author":"Joshi","year":"2002","journal-title":"J. Hematother. Stem Cell Res."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00262-001-0253-3","article-title":"Generation of functional dendritic cells for potential use in the treatment of acute lymphoblastic leukemia","volume":"51","author":"Pospisilova","year":"2002","journal-title":"Cancer Immunol. Immunother."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s002770000159","article-title":"Culture requirements for induction of dendritic cell differentiation in acute myeloid leukemia","volume":"79","author":"Oehler","year":"2000","journal-title":"Ann. Hematol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0145-2126(00)00120-X","article-title":"The efficient generation of CD83 positive immunocompetent dendritic cells from CD14 positive acute myelomonocytic or monocytic leukemia cells in vitro","volume":"25","author":"Hagihara","year":"2001","journal-title":"Leuk. Res."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF02981980","article-title":"The generation of immunocompetent dendritic cells from CD34+ acute myeloid or lymphoid leukemia cells","volume":"75","author":"Tsuchiya","year":"2002","journal-title":"Int. J. Hematol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0145-2126(01)00104-7","article-title":"Optimal cytokine stimulation for the enhanced generation of leukemic dendritic cells in short-term culture","volume":"26","author":"Panoskaltsis","year":"2002","journal-title":"Leuk. Res."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1182\/blood.V93.3.780","article-title":"Dendritic cells derived in vitro from acute myelogenous leukemia cells stimulate autologous, antileukemic T-cell responses","volume":"93","author":"Choudhury","year":"1999","journal-title":"Blood"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1182\/blood.V94.6.2048","article-title":"CD34+ acute myeloid and lymphoid leukemic blasts can be induced to differentiate into dendritic cells","volume":"94","author":"Cignetti","year":"1999","journal-title":"Blood"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1182\/blood.V97.9.2764","article-title":"Stimulation of autologous proliferative and cytotoxic T-cell responses by \u201cleukemic dendritic cells\u201d derived from blast cells in acute myeloid leukemia","volume":"97","author":"Harrison","year":"2001","journal-title":"Blood"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1038\/sj.leu.2402273","article-title":"An optimised biphasic culture system for the generation of functional dendritic cells from patients with acute lymphoblastic leukaemia at presentation and in clinical remission","volume":"15","author":"Blair","year":"2001","journal-title":"Leukemia"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/(SICI)1098-2264(199711)20:3<215::AID-GCC1>3.0.CO;2-5","article-title":"Dendritic cells generated from blood precursors of chronic myelogenous leukemia patients carry the Philadelphia translocation and can induce a CML-specific primary cytotoxic T-cell response","volume":"20","author":"Eibl","year":"1997","journal-title":"Genes Chromosomes Cancer"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0198-8859(96)00285-6","article-title":"Generation of dendritic cells expressing bcr-abl from CD34-positive chronic myeloid leukemia precursors","volume":"53","author":"Smit","year":"1997","journal-title":"Hum. Immunol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0145-2126(03)00011-0","article-title":"Dendritic cell vaccination for patients with chronic myelogenous leukemia","volume":"27","author":"Takahashi","year":"2003","journal-title":"Leuk. Res."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0301-472X(01)00636-1","article-title":"Leukemia blast-induced T-cell anergy demonstrated by leukemia-derived dendritic cells in acute myelogenous leukemia","volume":"29","author":"Narita","year":"2001","journal-title":"Exp. Hematol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1634\/stemcells.18-2-139","article-title":"Cytokine-driven differentiation of blasts from patients with acute myelogenous and lymphoblastic leukemia into dendritic cells","volume":"18","author":"Kohler","year":"2000","journal-title":"Stem Cells"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1182\/blood.V98.13.3750","article-title":"Circulating blood dendritic cells from myeloid leukemia patients display quantitative and cytogenetic abnormalities as well as functional impairment","volume":"98","author":"Mohty","year":"2001","journal-title":"Blood"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1365-2141.1995.tb08418.x","article-title":"Establishment of a myeloid leukaemic cell line (SKNO-1) from a patient with t(8;21) who acquired monosomy 17 during disease progression","volume":"89","author":"Matozaki","year":"1995","journal-title":"Br. J. Haematol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1046\/j.1423-0410.2003.00283.x","article-title":"Optimized culture conditions for the generation of dendritic cells from peripheral blood monocytes","volume":"84","author":"Moldenhauer","year":"2003","journal-title":"Vox Sang."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1046\/j.1365-2818.1997.1940755.x","article-title":"Drying cells for SEM, AEM and TEM by hexamethyldisilazane: a study on hepatic endothelial cells","volume":"186","author":"Braet","year":"1997","journal-title":"J. Microsc."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/jemt.1070260603","article-title":"Comparison of hexamethyldisilazene (HMDS), peldri II, and critical-point drying methods for scanning electron microscopy of biological specimens","volume":"26","author":"Bray","year":"1993","journal-title":"Microsc. Res. Tech."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","article-title":"Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei","volume":"11","author":"Dignam","year":"1983","journal-title":"Nucleic Acids Res."},{"key":"2023033100012384100_","first-page":"2517","article-title":"Molecular quantification of response to therapy and remission status in TEL-AML1-positive childhood ALL by real-time reverse transcription polymerase chain reaction","volume":"61","author":"Seeger","year":"2001","journal-title":"Cancer Res."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0022-1759(96)00007-5","article-title":"Detection and quantification of blood-derived CD8 + T-lymphocytes secreting tumor necrosis factor \u03b1 in response to HLA-A2.1-binding melanoma and viral peptide antigens","volume":"191","author":"Herr","year":"1996","journal-title":"J. Immunol. Methods"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1046\/j.1365-2141.1997.4283238.x","article-title":"CD34+ peripheral blood progenitor cell and monocyte derived dendritic cells: a comparative analysis","volume":"99","author":"Herbst","year":"1997","journal-title":"Br. J. Haematol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1084\/jem.182.1.163","article-title":"Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells","volume":"182","author":"Nijman","year":"1995","journal-title":"J. Exp. Med."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00000658-199707000-00002","article-title":"Generation of dendritic cells in vitro from peripheral blood mononuclear cells with granulocyte-macrophage-colony-stimulating factor, inlerleukin-4, and tumor necrosis factor-\u03b1 for use in cancer immunotherapy","volume":"226","author":"Morse","year":"1997","journal-title":"Ann. Surg."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1002\/eji.1830201103","article-title":"Interleukin 4 down-regulates the expression of CD14 in normal human monocytes","volume":"20","author":"Lauener","year":"1990","journal-title":"Eur. J. Immunol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.4049\/jimmunol.160.3.1224","article-title":"Vascular endothelial growth factor affects dendritic cell maturation through inhibition of nuclear factor-\u03baB activation in hematopoietic progenitor cells","volume":"160","author":"Oyama","year":"1998","journal-title":"J. Immunol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1084\/jem.170.2.577","article-title":"Inhibition of human macrophage colony formation by interleukin 4","volume":"170","author":"Jansen","year":"1989","journal-title":"J. Exp. Med."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1146\/annurev.iy.12.040194.004313","article-title":"The CD40 antigen and its ligand","volume":"12","author":"Banchereau","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1084\/jem.185.2.341","article-title":"CD40 ligation on human cord blood CD34 + hematopoietic progenitors induces their proliferation and differentiation into functional dendritic cells","volume":"185","author":"Flores-Romo","year":"1997","journal-title":"J. Exp. Med."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1182\/blood.V92.11.4238","article-title":"Generation of functional human dendritic cells from adherent peripheral blood monocytes by CD40 ligation in the absence of granulocyte-macrophage colony-stimulating factor","volume":"92","author":"Brossart","year":"1998","journal-title":"Blood"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1002\/(SICI)1521-4141(199908)29:08<2567::AID-IMMU2567>3.0.CO;2-S","article-title":"Human acute myeloblastic leukemia cells differentiate in vitro into mature dendritic cells and induce the differentiation of cytotoxic T cells against autologous leukemias","volume":"29","author":"Charbonnier","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1079-9796(03)00120-7","article-title":"Autologous immunotherapy for human leukemias","volume":"31","author":"Claxton","year":"2003","journal-title":"Blood Cells Mol. Dis."},{"key":"2023033100012384100_","first-page":"2861","article-title":"Induction of leukemia-specific cytotoxic response by cross-presentation of late-apoptotic leukemic blasts by autologous dendritic cells of nonleukemic origin","volume":"62","author":"Spisek","year":"2002","journal-title":"Cancer Res."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/89008","article-title":"The allogeneic response and tumor immunity","volume":"7","author":"Fabre","year":"2001","journal-title":"Nat. Med."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.4049\/jimmunol.168.6.2599","article-title":"Cutting edge: CD83 regulates the development of cellular immunity CD83 is a sialic acid-binding Ig-like lectin (Siglec) adhesion receptor that binds monocytes and a subset of activated CD8+ T cells","volume":"168","author":"Scholler","year":"2002","journal-title":"J. Immunol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000065883","article-title":"Role of CD83 in the immunomodulation of dendritic cells genetically modified dendritic cells in cancer therapy: implications for transfusion medicine","volume":"129","author":"Lechmann","year":"2002","journal-title":"Int. Arch. Allergy Immunol."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/j.1349-7006.2000.tb00899.x","article-title":"Apoptotic cytotoxic effects of a histone deacetylase inhibitor, FK228, on malignant lymphoid cells","volume":"91","author":"Murata","year":"2000","journal-title":"Jpn. J. Cancer Res."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/sj.cdd.4400914","article-title":"Inhibition of histone deacetylase activity enhances Fas receptor-mediated apoptosis in leukemic lymphoblasts","volume":"8","author":"Bernhard","year":"2001","journal-title":"Cell Death Differ."},{"key":"2023033100012384100_","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S0006-2952(02)01261-3","article-title":"Effects of FK228, a novel histone deacetylase inhibitor, on human lymphoma U-937 cells in vitro and in vivo","volume":"64","author":"Sasakawa","year":"2002","journal-title":"Biochem. Pharmacol."}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1189%2Fjlb.1103581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/76\/3\/623\/49655432\/jlb0623.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/76\/3\/623\/49655432\/jlb0623.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T21:19:11Z","timestamp":1682716751000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/76\/3\/623\/6926458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6,14]]},"references-count":65,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,6,14]]},"published-print":{"date-parts":[[2004,6,14]]}},"URL":"https:\/\/doi.org\/10.1189\/jlb.1103581","relation":{},"ISSN":["0741-5400","1938-3673"],"issn-type":[{"value":"0741-5400","type":"print"},{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2004,9]]},"published":{"date-parts":[[2004,6,14]]}}}