{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:11:16Z","timestamp":1760170276100,"version":"3.37.3"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T00:00:00Z","timestamp":1143676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA13547","DA12815"],"award-info":[{"award-number":["AA13547","DA12815"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acute and chronic alcohol abuse impairs various functions of the immune system and thus, has been implicated as a cofactor in the immunopathogenesis of human immunodeficiency virus (HIV) disease progression. We determined whether naltrexone, an opioid receptor antagonist widely used in the treatment of alcoholism, inhibits alcohol-mediated enhancement of HIV infection of T cells. Alcohol enhanced HIV infection of peripheral blood lymphocytes (PBL) and a human lymphoid cell line (CEMX174). Alcohol increased HIV X4 envelope (Env), not murine leukemia virus Env-pseudotyped infection of CEMX174 cells. Naltrexone antagonized the enhancing effect of alcohol on HIV infection of PBL and CEMX174 cells. The specific \u03bc-opioid receptor antagonist, Cys2, Tyr3, Arg5, Pen7 (CTAP) amide, also blocked the enhancing effect of alcohol on HIV infection. Investigation of the underlying mechanism for the alcohol action showed that alcohol significantly increased endogenous \u03b2-endorphin production and induced \u03bc-opioid receptor mRNA expression in PBL and CEMX174 cells. The role of \u03b2-endorphin in alcohol-mediated enhancement of HIV infection was indicated by the observations that naltrexone and CTAP antagonized ether alcohol- or exogenous \u03b2-endorphin-mediated enhancement of HIV infection. These findings suggest a biological mechanism for the potential therapeutic benefit of naltrexone in treating HIV-infected alcoholics.<\/jats:p>","DOI":"10.1189\/jlb.1105642","type":"journal-article","created":{"date-parts":[[2006,3,31]],"date-time":"2006-03-31T01:40:31Z","timestamp":1143769231000},"page":"1166-1172","source":"Crossref","is-referenced-by-count":14,"title":["Naltrexone inhibits alcohol-mediated enhancement of HIV infection of T lymphocytes"],"prefix":"10.1093","volume":"79","author":[{"given":"Xu","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Allergy and Immunology, Joseph Stokes Jr. Research Institute at the Children\u2019s Hospital of Philadelphia, Department of Pediatrics , Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D","family":"Douglas","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Joseph Stokes Jr. Research Institute at the Children\u2019s Hospital of Philadelphia, Department of Pediatrics , Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Song","family":"Peng","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Wuhan Center for Disease Prevention and Control , People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S","family":"Metzger","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Center for Studies of Addiction, University of Pennsylvania School of Medicine , Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles P","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Center for Studies of Addiction, University of Pennsylvania School of Medicine , Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Joseph Stokes Jr. Research Institute at the Children\u2019s Hospital of Philadelphia, Department of Pediatrics , Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Zhe","family":"Ho","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Joseph Stokes Jr. Research Institute at the Children\u2019s Hospital of Philadelphia, Department of Pediatrics , Philadelphia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,3,30]]},"reference":[{"key":"2023033015234747600_cit-1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0024-3205(80)90257-X","article-title":"Alteration of ethanol self-administration by naltrexone","volume":"26","author":"Altshuler","year":"1980","journal-title":"Life Sci."},{"key":"2023033015234747600_cit-2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1056\/NEJMcp042262","article-title":"Clinical practice. 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