{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:01:40Z","timestamp":1791388900564,"version":"4.3.3"},"reference-count":71,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T00:00:00Z","timestamp":1211328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["CA106345"],"award-info":[{"award-number":["CA106345"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL069442"],"award-info":[{"award-number":["HL069442"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During inflammation, cell surface adhesion molecules guide the adhesion and migration of circulating leukocytes across the endothelial cells lining the blood vessels to access the site of injury. The transmembrane molecule CD13 is expressed on monocytes and endothelial cells and has been shown to mediate homotypic cell adhesion, which may imply a role for CD13 in inflammatory monocyte trafficking. Here, we show that ligation and clustering of CD13 by mAb or viral ligands potently induce myeloid cell\/endothelial adhesion in a signal transduction-dependent manner involving monocytic cytoskeletal rearrangement and filopodia formation. Treatment with soluble recombinant (r)CD13 blocks this CD13-dependent adhesion, and CD13 molecules from monocytic and endothelial cells are present in the same immunocomplex, suggesting a direct participation of CD13 in the adhesive interaction. This concept is strengthened by the fact that activated monocytic cells adhere to immobilized recombinant CD13. Furthermore, treatment with anti-CD13 antibodies in a murine model of peritonitis results in a decrease in leukocyte infiltration into the peritoneum, suggesting a potential role for CD13 in leukocyte trafficking in vivo. Therefore, this work supports a new direction for CD13 biology, where these cell surface molecules act as true molecular interfaces that induce and participate in critical inflammatory cell interactions.<\/jats:p>","DOI":"10.1189\/jlb.1107802","type":"journal-article","created":{"date-parts":[[2008,5,22]],"date-time":"2008-05-22T00:54:21Z","timestamp":1211417661000},"page":"448-459","source":"Crossref","is-referenced-by-count":85,"title":["CD13 is a novel mediator of monocytic\/endothelial cell adhesion"],"prefix":"10.1093","volume":"84","author":[{"given":"Paola","family":"Mina-Osorio","sequence":"first","affiliation":[{"name":"Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center , Farmington, Connecticut , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Winnicka","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center , Farmington, Connecticut , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"O\u2019Conor","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center , Farmington, Connecticut , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina L","family":"Grant","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center , Farmington, Connecticut , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte K","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rodriguez-Pinto","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center , Farmington, Connecticut , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn V","family":"Holmes","sequence":"additional","affiliation":[{"name":"Molecular Biology Program, University of Colorado at Denver and Health Sciences Center , Aurora, Colorado , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Ortega","sequence":"additional","affiliation":[{"name":"Department of Immunology, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico , M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda H","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center , Farmington, Connecticut , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,5,21]]},"reference":[{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1549-8719.2001.tb00168.x","article-title":"Migration of leukocytes across endothelial junctions: some concepts and controversies","volume":"8","author":"Muller","year":"2001","journal-title":"Microcirculation"},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/ni1275","article-title":"Immune cell migration in inflammation: present and future therapeutic targets","volume":"6","author":"Luster","year":"2005","journal-title":"Nat. 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Cell Biol."},{"key":"2023032712473586500_","first-page":"867","article-title":"Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells","volume":"62","author":"Curnis","year":"2002","journal-title":"Cancer Res."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.1074\/jbc.M006916200","article-title":"Inhibition of the calcium-dependent tyrosine kinase (CADTK) blocks monocyte spreading and motility","volume":"276","author":"Watson","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nri1268","article-title":"Role of the cytoskeleton during leukocyte responses","volume":"4","author":"Vicente-Manzanares","year":"2004","journal-title":"Nat. Rev. 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Immunol."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.4049\/jimmunol.155.7.3578","article-title":"Characterization of intercellular adhesion molecule-1 ectodomain (sICAM-1) as an inhibitor of lymphocyte function-associated molecule-1 interaction with ICAM-1","volume":"155","author":"Meyer","year":"1995","journal-title":"J. Immunol."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0002-9440(10)64975-9","article-title":"Targeted disruption of the galectin-3 gene results in attenuated peritoneal inflammatory responses","volume":"156","author":"Hsu","year":"2000","journal-title":"Am. J. Pathol."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"12871","DOI":"10.1074\/jbc.M611725200","article-title":"Cadherin conformations associated with dimerization and adhesion","volume":"282","author":"Tsuiji","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0960-9822(06)00154-0","article-title":"Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function","volume":"7","author":"Yap","year":"1997","journal-title":"Curr. Biol."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1084\/jem.182.5.1231","article-title":"Intercellular adhesion molecule-1 dimerization and its consequences for adhesion mediated by lymphocyte function associated-1","volume":"182","author":"Miller","year":"1995","journal-title":"J. Exp. Med."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.4049\/jimmunol.171.5.2225","article-title":"CD28 engagement promotes actin polymerization through the activation of the small Rho GTPase Cdc42 in human T cells","volume":"171","author":"Salazar-Fontana","year":"2003","journal-title":"J. Immunol."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1083\/jcb.128.4.661","article-title":"P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin","volume":"128","author":"Moore","year":"1995","journal-title":"J. Cell Biol."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/41.3.7679125","article-title":"Detection and spatial distribution of the \u03b2 2 integrin (Mac-1) and L-selectin (LECAM-1) adherence receptors on human neutrophils by high-resolution field emission SEM","volume":"41","author":"Erlandsen","year":"1993","journal-title":"J. Histochem. Cytochem."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.0959-9673.2006.00450.x","article-title":"A vitellogenic-like carboxypeptidase expressed by human macrophages is localized in endoplasmic reticulum and membrane ruffles","volume":"87","author":"Harris","year":"2006","journal-title":"Int. J. Exp. Pathol."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1083\/jcb.200503059","article-title":"Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells","volume":"170","author":"Lehmann","year":"2005","journal-title":"J. Cell Biol."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/ncb1544","article-title":"Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission","volume":"9","author":"Sherer","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"2023032712473586500_","first-page":"27","article-title":"Monocyte adhesion to endothelium in simian immunodeficiency virus-induced AIDS encephalitis is mediated by vascular cell adhesion molecule-1\/\u03b1 4 \u03b2 1 integrin interactions","volume":"144","author":"Sasseville","year":"1994","journal-title":"Am. J. Pathol."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1002\/jlb.65.5.614","article-title":"Influenza A virus up-regulates neutrophil adhesion molecules and adhesion to biological surfaces","volume":"65","author":"Hartshorn","year":"1999","journal-title":"J. Leukoc. Biol."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.4049\/jimmunol.176.9.5463","article-title":"Enhancement of LFA-1-mediated T cell adhesion by human T lymphotropic virus type 1 p12I1","volume":"176","author":"Kim","year":"2006","journal-title":"J. Immunol."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1074\/jbc.M003758200","article-title":"Characterization of intercellular adhesion molecule-1 regulation by Epstein-Barr virus-encoded latent membrane protein-1 identifies pathways that cooperate with nuclear factor \u03ba B to activate transcription","volume":"276","author":"Mehl","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2023032712473586500_","doi-asserted-by":"crossref","first-page":"4774","DOI":"10.4049\/jimmunol.156.12.4774","article-title":"Respiratory syncytial virus infection enhances neutrophil and eosinophil adhesion to cultured respiratory epithelial cells. Roles of CD18 and intercellular adhesion molecule-1","volume":"156","author":"Stark","year":"1996","journal-title":"J. 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