{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:42:17Z","timestamp":1790390537620,"version":"4.1.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2009,12,9]],"date-time":"2009-12-09T00:00:00Z","timestamp":1260316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI056082"],"award-info":[{"award-number":["AI056082"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Roswell Park Cancer Institute's National Cancer Institute-funded Cancer Center","award":["CA16056"],"award-info":[{"award-number":["CA16056"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>ST6Gal-1 is a participant in regulating not only Th1 but also Th2 responses; ST6Gal-1 deficiency can lead to the development of more severe allergic inflammation with excessive eosinophil production.<\/jats:p>\n               <jats:p>Cumulative evidence indicates that the sialyltransferase ST6Gal-1 and the sialyl-glycans, which it constructs, are functionally pleiotropic. Expression of the ST6Gal-1 gene is mediated by six distinct promoter\/regulatory regions, and we hypothesized that these promoters may be used differentially to produce ST6Gal-1 for different biologic purposes. To examine this hypothesis, we compared a mouse with a complete deficiency in ST6Gal-1 (Siat1 null) with another mouse that we have created previously with a disruption only in the P1 promoter (Siat1\u0394P1). We noted previously greater neutrophilic inflammation associated with ST6Gal-1 deficiency. Here, we report that ST6Gal-1-deficient mice also have significantly elevated eosinophilic responses. Upon i.p. thioglycollate elicitation, eosinophils accounted for over 20% of the total peritoneal inflammatory cell pool in ST6Gal-1-deficient animals, which was threefold greater than in corresponding wild-type animals. A principal feature of allergic respiratory inflammation is pulmonary eosinophilia, we evaluated the role of ST6Gal-1 in allergic lung inflammation. Using OVA and ABPA experimental models of allergic airways, we showed that ST6Gal-1 deficiency led to greater airway inflammation characterized by excessive airway eosinophilia. The severity of airway inflammation was similar between Siat1\u0394P1 and Siat1 null mice, indicating a role for P1-generated ST6Gal-1 in regulating eosinophilic inflammation. Colony-forming assays suggested greater IL-5-dependent eosinophil progenitor numbers in the marrow of ST6Gal-1-deficient animals. Moreover, allergen provocation of wild-type mice led to a significant reduction in P1-mediated ST6Gal-1 mRNA and accompanied decline in circulatory ST6Gal-1 levels. Taken together, the data implicate ST6Gal-1 as a participant in regulating not only Th1 but also Th2 responses, and ST6Gal-1 deficiency can lead to the development of more severe allergic inflammation with excessive eosinophil production.<\/jats:p>","DOI":"10.1189\/jlb.1108704","type":"journal-article","created":{"date-parts":[[2009,12,10]],"date-time":"2009-12-10T01:46:25Z","timestamp":1260409585000},"page":"457-466","source":"Crossref","is-referenced-by-count":39,"title":["Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation"],"prefix":"10.1093","volume":"87","author":[{"given":"Mehrab","family":"Nasirikenari","sequence":"first","affiliation":[{"name":"Departments of Molecular and Cellular Biology, Roswell Park Cancer Institute , Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E V","family":"Chandrasekaran","sequence":"additional","affiliation":[{"name":"Departments of Cancer Biology, Roswell Park Cancer Institute , Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushi L","family":"Matta","sequence":"additional","affiliation":[{"name":"Departments of Cancer Biology, Roswell Park Cancer Institute , Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahm H","family":"Segal","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Roswell Park Cancer Institute , Buffalo, New York, USA"},{"name":"Departments of Immunology, Roswell Park Cancer Institute , Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N","family":"Bogner","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Roswell Park Cancer Institute , Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit A","family":"Lugade","sequence":"additional","affiliation":[{"name":"Departments of Immunology, Roswell Park Cancer Institute , Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmin","family":"Thanavala","sequence":"additional","affiliation":[{"name":"Departments of Immunology, Roswell Park Cancer Institute , Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona , Scottsdale, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph T Y","family":"Lau","sequence":"additional","affiliation":[{"name":"Departments of Molecular and Cellular Biology, Roswell Park Cancer Institute , Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,12,9]]},"reference":[{"key":"2023032913441763700_jlb0457-cit-b1","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1084\/jem.20070846","article-title":"Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation","volume":"205","author":"Frommhold","year":"2008","journal-title":"J. Exp. Med."},{"key":"2023032913441763700_jlb0457-cit-b2","doi-asserted-by":"crossref","first-page":"10042","DOI":"10.1073\/pnas.142005099","article-title":"Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands","volume":"99","author":"Ellies","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023032913441763700_jlb0457-cit-b3","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nm1760","article-title":"The Ashwell receptor mitigates the lethal coagulopathy of sepsis","volume":"14","author":"Grewal","year":"2008","journal-title":"Nat. Med."},{"key":"2023032913441763700_jlb0457-cit-b4","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1074-7613(00)80180-6","article-title":"The ST3Gal-I sialyltransferase controls CD8+ T lymphocyte homeostasis by modulating O-glycan biosynthesis","volume":"12","author":"Priatel","year":"2000","journal-title":"Immunity"},{"key":"2023032913441763700_jlb0457-cit-b5","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1073\/pnas.95.8.4504","article-title":"Immune regulation by the ST6Gal sialyltransferase","volume":"95","author":"Hennet","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023032913441763700_jlb0457-cit-b6","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.4049\/jimmunol.177.5.3063","article-title":"CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo","volume":"177","author":"Haas","year":"2006","journal-title":"J. Immunol."},{"key":"2023032913441763700_jlb0457-cit-b7","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/intimm\/dxh402","article-title":"Regulation of B cell development and B cell signaling by CD22 and its ligands {\u03b1}2, 6-linked sialic acids","volume":"18","author":"Ghosh","year":"2006","journal-title":"Int. Immunol."},{"key":"2023032913441763700_jlb0457-cit-b8","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ni1283","article-title":"Ablation of CD22 in ligand-deficient mice restores B cell receptor signaling","volume":"7","author":"Collins","year":"2006","journal-title":"Nat. Immunol."},{"key":"2023032913441763700_jlb0457-cit-b9","doi-asserted-by":"crossref","first-page":"37610","DOI":"10.1074\/jbc.M508476200","article-title":"A protein kinase C\/Ras\/ERK signaling pathway activates myeloid fibronectin receptors by altering \u03b21 integrin sialylation","volume":"280","author":"Seales","year":"2005","journal-title":"J. Biol. 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