{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:45:17Z","timestamp":1788871517777,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health, Labor, and Welfare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fiz1 and Hipk2 contribute to lymphomagenesis via activation of IL-7 signaling pathway.<\/jats:p>\n                  <jats:p>IL-7R, FLT3, and CD43 are surface antigens expressed during the transition from pro-B to pre-B cells in BM. To understand interactions between their signaling pathways, we analyzed spontaneous mouse B-LBLs with dual MLV integration into Stat5a and Fiz1 or Stat5a and Hipk2. MLV integration resulted in up-regulation of these genes in lymphoma cells compared with normal pro-B cells from the BM. In lymphomas with both integrations into Stat5a and Fiz1, increases in phosphorylated STAT5A and expression of c-Myc, a target gene of STAT5A, were observed following stimulation of the FLT3. Clones with the dual integrations grew faster in IL-7 and FLT3L-supplemented medium than clones with Stat5a integration alone. On the other hand, in lymphomas with integrations into Stat5a and Hipk2, increases in phosphorylated STAT5A and expression of c-Myc were observed following cross-linking of CD43. In conclusion, FLT3 and CD43 signaling pathways involve STAT5A via Fiz1 and Hipk2 in B-LBLs. Identification of the dual MLV integration sites in B-LBLs, therefore, will provide an excellent tool for identification of the signaling pathways in B-LBLs.<\/jats:p>","DOI":"10.1189\/jlb.1109748","type":"journal-article","created":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T22:04:17Z","timestamp":1270159457000},"page":"107-116","source":"Crossref","is-referenced-by-count":21,"title":["Dual retrovirus integration tagging: identification of new signaling molecules\n                    <i>Fiz1<\/i>\n                    and\n                    <i>Hipk2<\/i>\n                    that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas"],"prefix":"10.1093","volume":"88","author":[{"given":"Tatsuaki","family":"Tsuruyama","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine and Molecular Pathology, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Molecular Pathology, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruya","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Molecular Pathology, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Hiratsuka","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Human Health Science, Graduate School of Medicine, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Kanaya","sequence":"additional","affiliation":[{"name":"Department of Human Health Science, Graduate School of Medicine, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kaszynski","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Molecular Pathology, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Jin","sequence":"additional","affiliation":[{"name":"Laboratory of Carcinogenesis, Cancer Institute , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Okuno","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Molecular Pathology, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munetaka","family":"Ozeki","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Molecular Pathology, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Laboratory of Carcinogenesis, Cancer Institute , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Takakuwa","sequence":"additional","affiliation":[{"name":"Department of Human Health Science, Graduate School of Medicine, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Manabe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Molecular Pathology, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Hiai","sequence":"additional","affiliation":[{"name":"Shiga Medical Center Research Institute , Shiga, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,4,1]]},"reference":[{"key":"2023033005105813100_cit1","volume-title":"Retroviruses","author":"Coffin","year":"1997"},{"key":"2023033005105813100_cit2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ng949","article-title":"New genes involved in cancer identified by retroviral tagging","volume":"32","author":"Suzuki","year":"2002","journal-title":"Nat. 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